Because the thickness of orthotropic steel deck is thin and the stiffness of pavement is relatively large, the interaction between orthotropic steel deck and pavement on it can not be neglected in the fatigue design of orthotropic steel deck. Based on the assumption of non-slip between pavement and the bridge deck, influences of elastic modulus and thickness of pavement on the fatigue stress range of four typical details in orthotropic steel deck were discussed according to FEM(finite element method) analysis results.