A newly developed technology for the pretreatment of copper anode slime, which has a prosperous industrial application prospect was introduced. Small-scale and half-industrialized tests show that direct pressure acid leaching of copper anode slime can make full use of the catalyzed oxidation of the water soluble copper ion in raw copper anode slime and quicken reaction speed. The trends of Ag, Se and Te in continuous leaching process are obviously different from those in discontinuous leaching process, and the leaching results are better than those of discontinuous pressure leaching technology. The new technology is good for comprehensive recycle of valuable elements.