Based on the chassis of a car, a multi-body dynamics model was built with ADAMS software. With the objective evaluation index for maneuverability of vehicle, ADAMS function was built to evaluate vehicle maneuverability. Orthogonal optimization design was applied to optimizing vehicle maneuverability with ADAMS software. The applying virtual prototyping technology for vehicle maneuverability and structure orthogonal optimization not only increases accuracy of simulation model compared with lumped-mass model, but also finds the main factors influencing the vehicle maneuverability and gets the optimization levels of the influence factors. The design process can be used in industrial organization.