A method of multi-sensor information fusion based on rough sets and fuzzy logic is proposed in this paper. Rough-fuzzy model can be built by obtaining general simplified rules from the large number of data using rough sets theory and methods of computing reduces. The concepts of expansion and perfection to the model are also presented. Finally the simulations and experiments of pulse vacuum disinfection control system are carried out using this method, the research results show the method is effective and feasible.