Urokinase-type plasminogen actor (uPA)system is a essential member of plasmin system. uPA system participates in the reconstruction of tissues and immigration of tumor cells by the degradation of the extracellular matrix, and then takes a important role in the invasion and metastasis of malignant tumors. This article is about the relationship beween uPA system and carcinoma of endometrium, in order to provide some new ideas for the diagnosis and theraphy of carcinoma of endometrium.