Based on prototype analysis of epidemic disease and ancient therapy (such as iron method, fire moxibustion and acupuncture therapy) , the author has explored the relationship between epidemic disease (especially bubonic plague) and medicine origin. From the point of view that medicine comes of epidemic disease, the author has conducted research on rich resources of Chinese cultural relics, ancient writing and medical literature on medicine history, including the difference between ancient name and modem name of disease, difference between TCM and Western medicine in terms of methodology. It would provide precious reference for the analysis and promotion of TCM achievement on epidemic disease and for the research on combination of TCM and Western medicine, sustainable development of TCM and international promotion of TCM.