In order to get rid of the dependence on the designers* experience, exploring a science- based design methodology becomes one of the research kernels. The Theory of Inventive Problem Solving and Axiomatic Design have lately gained popularity as they are developed based on scientific principles. In this paper, the relationship and differences between these two design methodologies are analyzed, and one integrated design model for the concept design phase is established. Finally, two cases are given to testify the feasibility of the proposed model.