It's described the influence of grinding environment on the surface morphology and property, the chemical property of pulp and its flotation behavior of sulfide minerals at home and abroad. During grinding of sulfide minerals, the factors of mechanics, electrochemistry, and mechano-chemistry etc. , affect the surface morphology and property, the chemical property of pulp and the flotation behavior of sulfide minerals, by complicated physical, chemical and physicochemical interactions. Controlling grinding environment by changing grinding medium, adding reagents into the mill and so on can improve separation effect of flotation of sulfide minerals.