The profound influence of economy globalization on the progress of the world, especially the impact on the development of China is described. It proposes that the globalization of R&D is a new stage of economy globalization. The rapid development of TNCs’ R&D in China is presented. The opportunities and challenges of R&D globalization for both developed and developing countries are discussed. The measures for encouraging globalization of R&D for developed, developing countries and UN are suggested.