The meridian (Jing-Luo) is a core principle of Chinese medicine. The meridian plays a central role in the regulation of human health and vitality. In the past 50 years,the scientific evidence has been gathered via physiological experiments to confirm the biological basis of the human meridian pathway phenomenon. Meridian Science has been established as a new branch of natural science to advance and promote the study of this important phenomenon for human life. In this paper, the authors describe the theoretical concept of the meridian and mathematics expression, its relationship to an efficient meridian circadian cycle, and its significance to human life.