Cruise missile achieves good flight performance by means of stabilization and regulation of its attitudes. Based on analysis of the perturbation model of missile*s dynamic characteristics, series control structures are constructed for attitude control loop, and their discrete models are served as controlled plant for recursive least square (RLS) based adaptive predictive control, thus the mass center control with slow response transforms into trajectory angle control with fast response and high precision. On the basis of missile’s characteristics, generalized predictive control (GPC) is used in inner attitude loop, and an integral form of predictive control is adopted in outter trajectory loop. Effective transformation from mass center command to trajectory reference has achieved to realize high precision tracking. This method realizes the integration of attitude reference signal with guidance command, and that of attitude control with mass center control. It can reduce precision requirements on aerodynamic data and the control parameters can be easily selected. The numerical simulations demonstrate its effectiveness. Finally, some further academic directions are presented.