Based on the theories, methods, technologies and tools of contemporary integrated manufacturing, the Complex System (Product) Integrated Manufacturing Engineering (COSIME) is presented and researched, aiming to improve the T (Time to market), Q (Quality), C (Cost), S (Service) of the complex product development. The connotation, system framework and technology system of COSIME are given. Furthermore, the phased research results of six key technologies are introduced： (1) the management mode of the complex product integrated manufacturing system based on the theory of the ” management of person with ability and institution” and the advanced manufacture patterns; (2) the concurrent engineering methods and techniques for the enterprises dispersed at different sites based on the theory of the project management; (3) the means and technologies of the virtual prototyping engineering for complex product; (4) the concept design and performance evaluation system for complex product based on the advanced distributed interactive simulation technology; (5) the quality control and management system for complex product; (6) the two integrated manufacturing infrastructures for the all lifecycle activities of complex product based on PLM and the grid computing technologies.