To investigate effects of testosterone propionate on patients with unstable angina, testosterone propionate (50mg, im) was given to 48 patients with unstable angina (test group), twice a week for 12 weeks. A group of patients with unstable angina were treated conventionally as a control. Clinical symptoms were evaluated and level of blood biochemistry was monitored before and after treatment. A dramatic improvement in clinical symptoms was observed in 46 out of 48 patients (96%) in the test group, demonstrating significant differences between the test and the control group (P＜0.01). In addition, the level of TC, LDL, CRP and TG reduced significantly and HDL - C increased slightly in the test group. However, no such changes were observed in the control group. A conclusion can be drawn that testosterone propionate can significantly improve clinical symptoms and blood biochemistry level in the patients with unstable angina, probably through modulating lipid metabolism, reducing inflammation response, and dilating blood vessel.