The structure, reproduction, replication and transcription of RNA viruses were introduced. Antivirus strategies including design of anti - SARS drugs, RNA interference, DNA vaccine delivery system, modulation of interaction of envelop glycoprotein with glycosanminoglycan derivatives or analogues, natural herbal medicine and alveolus tissue engineering were reviewed. These examples imply the interactions of RNA viruses with proteins, DNA, and polysaccharides. Nowadays biomaterials matrixes or vectors are developing toward the third generation, i.e. cell or/and activated ones. It is sure that biomaterials will play a crucial role in fighting against SARS viruses and the like.