In the case of more and more strict environmental protection regulations in the world, the paper reviews in detail the problems that refiner and R&D branch are confronted with during the production of clean gasoline fuel,the development trend of clean gasoline fuel in the world and the countermeasure that R&D branch should take in future. The significance, routes and chemical principle to produce isoparaffins, an important constituent in gasoline pool,in China are discussed emphatically.