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CD47 blockade improves the therapeutic effect of osimertinib in non-small cell lung cancer
《医学前沿(英文)》 2023年 第17卷 第1期 页码 105-118 doi: 10.1007/s11684-022-0934-1
关键词: osimertinib anti-CD47 antibody combination strategy ADCP EGFR
Activation of phagocytosis by immune checkpoint blockade
null
《医学前沿(英文)》 2018年 第12卷 第4期 页码 473-480 doi: 10.1007/s11684-018-0657-5
Inhibition of macrophage-mediated phagocytosis has emerged as an essential mechanism for tumor immune evasion. One mechanism inhibiting the innate response is the presence of the macrophage inhibitory molecule, signal regulatory protein-α (SIRPα), on tumor-associated macrophages (TAMs) and its cognate ligand cluster of differentiation 47 (CD47) on tumor cells in the tumor microenvironment. On the basis of a recently discovered programmed death protein 1 (PD-1) in TAMs, we discuss the potential inhibitory receptors that possess new functions beyond T cell exhaustion in this review. As more and more immune receptors are found to be expressed on TAMs, the corresponding therapies may also stimulate macrophages for phagocytosis and thereby provide extra anti-tumor benefits in cancer therapy. Therefore, identification of biomarkers and combinatorial therapeutic strategies, have the potential to improve the efficacy and safety profiles of current immunotherapies.
关键词: CD47 PD-1 PD-L1 immunotherapy TAM phagocytosis macrophage
《医学前沿(英文)》 2022年 第16卷 第1期 页码 139-149 doi: 10.1007/s11684-021-0835-8
关键词: B-cell acute lymphoblastic leukemia bispecific antibody trispecific antibody CD19 CD20
Electrocatalytic debromination of BDE-47 at palladized graphene electrode
Hongtao YU, Bin MA, Shuo CHEN, Qian ZHAO, Xie QUAN, Shahzad AFZAL
《环境科学与工程前沿(英文)》 2014年 第8卷 第2期 页码 180-187 doi: 10.1007/s11783-013-0552-x
Clinical significance of CD34+CD117dim/CD34+CD117bri myeloblast-associated
Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang
《医学前沿(英文)》 2021年 第15卷 第4期 页码 608-620 doi: 10.1007/s11684-021-0836-7
关键词: t(8 21)(q22 q22) AML CD34+CD117dim/ CD34+CD117bri cell population gene expression prognosis
Meng XUE, Yihui ZHOU, Zhongyi YANG, Biyun LIN, Jiangang YUAN, Shanshan WU
《环境科学与工程前沿(英文)》 2014年 第8卷 第2期 页码 226-238 doi: 10.1007/s11783-013-0582-4
关键词:
cadmium (Cd)
low-Cd cultivar
pakchoi (
Chaojin Jiang, Xiaoqian Jiang, Lixun Zhang, Yuntao Guan
《环境科学与工程前沿(英文)》 2020年 第14卷 第3期 doi: 10.1007/s11783-020-1224-2
关键词: 2 2′ 4 4′-tetrabromodiphenyl ether (BDE-47) Ascorbic acid Reductive debromination Zero-valent zinc
《环境科学与工程前沿(英文)》 2023年 第17卷 第7期 doi: 10.1007/s11783-023-1687-z
● Organic solvent extracted fewer Cd/Pb in rapeseed oil than physical pressing.
关键词: Rapeseed oil Oil extraction technologies Human health risk assessment Cd/Pb-contaminated farmland Substitute planting
Celecoxib in combination with retinoid CD437 inhibits melanoma A375 cell
Jianwen REN, Zhenhui PENG, Birong GUO, Min PAN
《医学前沿(英文)》 2009年 第3卷 第1期 页码 108-112 doi: 10.1007/s11684-009-0015-8
关键词: celecoxib CD437 melanoma A375 cell apoptosis cycle arrest
SUN Yuebing, ZHOU Qixing, WEI Shuhe, REN Liping
《环境科学与工程前沿(英文)》 2007年 第1卷 第1期 页码 107-113 doi: 10.1007/s11783-007-0020-6
《医学前沿(英文)》 doi: 10.1007/s11684-023-1010-1
关键词: exosomes induce activation impair function CD19 exosomal CD19 antigen
Changes of phenotype and function of human CD4 CD25 T cells induced by transfection of Foxp3
WU Kui, BI Yutian, WANG Yaoli, WANG Changzheng
《医学前沿(英文)》 2008年 第2卷 第4期 页码 366-369 doi: 10.1007/s11684-008-0070-6
Xia Hou, Liping Huang, Peng Zhou, Hua Xue, Ning Li
《环境科学与工程前沿(英文)》 2018年 第12卷 第4期 doi: 10.1007/s11783-018-1057-4
Cell membrane of indigenous Cd-tolerant EAB harbored more cadmium than chromium. Indigenous Cd-tolerant EAB cytoplasm located more chromium than cadmium. Simultaneously quantitatively imaging Cd(II) and Cr(III) ions in EAB was achieved. Current accelerated the harboring of cadmium in EAB at an initial 2 h. Current directed the accumulation of more chromium in EAB over time.
关键词: Microbial electrolysis cell Electrochemically active bacteria Cd-tolerant bacteria Cd(II) and Cr(VI) Fluorescence probe
null
《医学前沿(英文)》 2011年 第5卷 第1期 页码 101-105 doi: 10.1007/s11684-011-0111-4
It has been demonstrated that β-elemene could protect against carbon tetrachloride (CCl4)-induced liver fibrosis in our laboratory work, and the aim of this paper is to reveal the protective mechanisms of β-elemene. The hepatic fibrosis experimental model was induced by the hypodermical injection of CCl4 in Wistar male rats. β-elemene was intraperitoneally administered into rats for 8 weeks (0.1 mL/100 g bodyweight per day), and plasma endotoxin content was assayed by biochemistry. The serum TNF-α level was detected using radioactive immunity. CD14 expression in rat livers was measured by immunohistochemistry and Western blot. The results showed that β-elemene can downregulate the levels of plasma endotoxins, serum TNF-α, and hepatic CD14 expression in rats with liver fibrosis. β-elemene plays an important role in downregulating the lipopolysaccharide signal transduction pathway, a significant pathway in hepatic fibrosis development.
LU Ling, ZHANG Feng, PU Liyong, YAO Aihua, YU Yue, SUN Beicheng, LI Guoqiang, WANG Xuehao
《医学前沿(英文)》 2007年 第1卷 第4期 页码 373-376 doi: 10.1007/s11684-007-0072-9
标题 作者 时间 类型 操作
Preclinical characterization and comparison between CD3/CD19 bispecific and novel CD3/CD19/CD20 trispecific
期刊论文
Electrocatalytic debromination of BDE-47 at palladized graphene electrode
Hongtao YU, Bin MA, Shuo CHEN, Qian ZHAO, Xie QUAN, Shahzad AFZAL
期刊论文
Clinical significance of CD34+CD117dim/CD34+CD117bri myeloblast-associated
Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang
期刊论文
Comparisons in subcellular and biochemical behaviors of cadmium between low-Cd and high-Cd accumulation
Meng XUE, Yihui ZHOU, Zhongyi YANG, Biyun LIN, Jiangang YUAN, Shanshan WU
期刊论文
Enhanced debromination of 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) by zero-valent zinc with ascorbic
Chaojin Jiang, Xiaoqian Jiang, Lixun Zhang, Yuntao Guan
期刊论文
Cultivars and oil extraction techniques affect Cd/Pb contents and health risks in oil of rapeseed grownon Cd/Pb-contaminated farmland
期刊论文
Celecoxib in combination with retinoid CD437 inhibits melanoma A375 cell
Jianwen REN, Zhenhui PENG, Birong GUO, Min PAN
期刊论文
Growth responses of the newly-discovered Cd-hyperaccumulator Rorippa globosa and its accumulation characteristicsof Cd and As under joint stress of Cd and As
SUN Yuebing, ZHOU Qixing, WEI Shuhe, REN Liping
期刊论文
Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function ofCD19-specific CAR T-cells via TGF-β signaling
期刊论文
Changes of phenotype and function of human CD4 CD25 T cells induced by transfection of Foxp3
WU Kui, BI Yutian, WANG Yaoli, WANG Changzheng
期刊论文
Response of indigenous Cd-tolerant electrochemically active bacteria in MECs toward exotic Cr(VI) based
Xia Hou, Liping Huang, Peng Zhou, Hua Xue, Ning Li
期刊论文
Downregulation effects of beta-elemene on the levels of plasma endotoxin, serum TNF-alpha, and hepatic CD14
null
期刊论文