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Polymeric micelle nanocarriers in cancer research
Dae Hwan Shin, Yu Tong Tam, Glen S. Kwon
《化学科学与工程前沿(英文)》 2016年 第10卷 第3期 页码 348-359 doi: 10.1007/s11705-016-1582-2
关键词: nanomedicine parenteral poly(ethylene glycol) poly(lactic acid) reformulation
Kinetic-compartmental modelling of potassium-containing cellulose feedstock gasification
Attila Egedy, Lívia Gyurik, Tamás Varga, Jun Zou, Norbert Miskolczi, Haiping Yang
《化学科学与工程前沿(英文)》 2018年 第12卷 第4期 页码 708-717 doi: 10.1007/s11705-018-1767-y
Biomass is of growing interest as a secondary energy source and can be converted to fuels with higher energy density especially by pyrolysis or gasification. Understanding the mechanism and the kinetics of biomass pyrolysis (thermal decomposition) and gasification (conversion of organic material to gases) could be the key to the design of industrial devices capable of processing vast amounts of biomass feedstock. In our work real product components obtained in pyrolysis were took into consideration as well as char and oil as lumped components, and the kinetic constants for a biomass model compound (cellulose) pyrolysis and gasification were identified based on a proposed simplified reaction mechanism within a compartment model structure. A laboratory scale reactor was used for the physical experiments containing consecutive fast pyrolysis and gasification stages using alkali metal (K) containing feedstock, which has a significant effect on the cellulose pyrolysis and gasification. The detailed model was implemented in MATLAB/Simulink environment, and the unknown kinetic parameters were identified based on experimental data. The model was validated based on measurement data, and a good agreement was found. Based on the validated first principle model the optimal parameters were determined as 0.15 mL/min steam flow rate, and 4% K content.
关键词: biomass pyrolysis kinetic parameter identification compartment modelling optimisation
The Immense Impact of Reverse Edges on Large Hierarchical Networks
Haosen Cao,Bin-Bin Hu,Xiaoyu Mo,Duxin Chen,Jianxi Gao,Ye Yuan,Guanrong Chen,Tamás Vicsek,Xiaohong Guan
《工程(英文)》 doi: 10.1016/j.eng.2023.06.011
关键词: Synchronizability Large hierarchical networks Reverse edges Information flows Complex networks
Behaviors of recycled aggregate concrete-filled steel tubular columns under eccentric loadings
TAM, Jianzhuang XIAO, Sheng LIU, Zixuan CHEN
《结构与土木工程前沿(英文)》 2019年 第13卷 第3期 页码 628-639 doi: 10.1007/s11709-018-0501-7
关键词: concrete filled steel tubes recycled aggregate concrete columns expansive agent eccentric load
Effect of fly ash and slag on concrete: Properties and emission analyses
TAM, Khoa N. LE, Ana Catarina Jorge EVANGELISTA, Anthony BUTERA, Cuong N. N. TRAN, Ashraf TEARA
《工程管理前沿(英文)》 2019年 第6卷 第3期 页码 395-405 doi: 10.1007/s42524-019-0019-2
Activation of phagocytosis by immune checkpoint blockade
null
《医学前沿(英文)》 2018年 第12卷 第4期 页码 473-480 doi: 10.1007/s11684-018-0657-5
Inhibition of macrophage-mediated phagocytosis has emerged as an essential mechanism for tumor immune evasion. One mechanism inhibiting the innate response is the presence of the macrophage inhibitory molecule, signal regulatory protein-α (SIRPα), on tumor-associated macrophages (TAMs) and its cognate ligand cluster of differentiation 47 (CD47) on tumor cells in the tumor microenvironment. On the basis of a recently discovered programmed death protein 1 (PD-1) in TAMs, we discuss the potential inhibitory receptors that possess new functions beyond T cell exhaustion in this review. As more and more immune receptors are found to be expressed on TAMs, the corresponding therapies may also stimulate macrophages for phagocytosis and thereby provide extra anti-tumor benefits in cancer therapy. Therefore, identification of biomarkers and combinatorial therapeutic strategies, have the potential to improve the efficacy and safety profiles of current immunotherapies.
关键词: CD47 PD-1 PD-L1 immunotherapy TAM phagocytosis macrophage
越南广平和顺化两省猪场分离副猪嗜血杆菌的抗生素耐药表型和耐药基因之间的相关性研究 Article
Chao Nguyen Van, 张丽君, Tam Vu Thi Thanh, Hung Pham Hoang Son, Tuan Tran Ngoc, 黄琦, 周锐
《工程(英文)》 2020年 第6卷 第1期 页码 40-48 doi: 10.1016/j.eng.2019.10.014
副猪嗜血杆菌是一种对全球养猪业造成重大经济损失的病原菌。副猪嗜血杆菌防控失败的原因之一是细菌耐药性不断加重。越南拥有亚洲排名第二的生猪产量,但是缺乏针对副猪嗜血杆菌耐药性的相关研究和数据。本研究的目的是调查越南副猪嗜血杆菌的耐药性,并分析耐药性和耐药性基因之间的关系。本研究所使用的副猪嗜血杆菌分离菌株来自我们之前研究中从越南广平省和顺化省猪场分离到的菌株。本研究分别利用肉汤微稀释法和聚合酶链反应(PCR)法检测了这些菌株对25种抗生素的耐药性及相关耐药基因的存在情况。结果显示,这些分离株对甲氧苄啶/磺胺甲恶唑的耐药率达高到94.6%,其次是黏菌素、氯霉素、庆大霉素、青霉素、林可霉素和阿莫西林。这些菌株中相关联耐药基因的检出率分别为blaTEM-1 94.6%、int 76.8%、gyrA 58.9%以及rmtD 50.0%。头孢呋辛、氯霉素和妥布霉素的耐药性表型分别与耐药基因blaROB-1 [优势比(OR) = 26.3, 95% 置信区间(CI)2.7~255.7, p = 0.002]、catl (OR = 25.1, 95% CI 2.4~258.9, p = 0.004)以及strB (OR = 23.5, 95% CI 2.6~212.6, p = 0.001)呈显著正相关。本研究首次揭示了越南中部地区副猪嗜血杆菌的耐药性情况,有助于该疾病的临床控制,能够为降低越南中部的养猪业中该菌的耐药性以及为相关政策制定和临床用药提供指导。
关键词: 副猪嗜血杆菌,抗药性,耐药基因,越南
Nucleic acid-based diagnostics for infectious diseases in public health affairs
null
《医学前沿(英文)》 2012年 第6卷 第2期 页码 173-186 doi: 10.1007/s11684-012-0195-5
Infectious diseases, mostly caused by bacteria and viruses but also a result of fungal and parasitic infection, have been one of the most important public health concerns throughout human history. The first step in combating these pathogens is to get a timely and accurate diagnosis at an affordable cost. Many kinds of diagnostics have been developed, such as pathogen culture, biochemical tests and serological tests, to help detect and fight against the causative agents of diseases. However, these diagnostic tests are generally unsatisfactory because they are not particularly sensitive and specific and are unable to deliver speedy results. Nucleic acid-based diagnostics, detecting pathogens through the identification of their genomic sequences, have shown promise to overcome the above limitations and become more widely adopted in clinical tests. Here we review some of the most popular nucleic acid-based diagnostics and focus on their adaptability and applicability to routine clinical usage. We also compare and contrast the characteristics of different types of nucleic acid-based diagnostics.
关键词: nucleic acid-based diagnostics infectious disease PCR NASBA LAMP microarray LOAC public health affairs
标题 作者 时间 类型 操作
Kinetic-compartmental modelling of potassium-containing cellulose feedstock gasification
Attila Egedy, Lívia Gyurik, Tamás Varga, Jun Zou, Norbert Miskolczi, Haiping Yang
期刊论文
The Immense Impact of Reverse Edges on Large Hierarchical Networks
Haosen Cao,Bin-Bin Hu,Xiaoyu Mo,Duxin Chen,Jianxi Gao,Ye Yuan,Guanrong Chen,Tamás Vicsek,Xiaohong Guan
期刊论文
Behaviors of recycled aggregate concrete-filled steel tubular columns under eccentric loadings
TAM, Jianzhuang XIAO, Sheng LIU, Zixuan CHEN
期刊论文
Effect of fly ash and slag on concrete: Properties and emission analyses
TAM, Khoa N. LE, Ana Catarina Jorge EVANGELISTA, Anthony BUTERA, Cuong N. N. TRAN, Ashraf TEARA
期刊论文
越南广平和顺化两省猪场分离副猪嗜血杆菌的抗生素耐药表型和耐药基因之间的相关性研究
Chao Nguyen Van, 张丽君, Tam Vu Thi Thanh, Hung Pham Hoang Son, Tuan Tran Ngoc, 黄琦, 周锐
期刊论文