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Inhibition of the nuclear export of p65 and IQCG in leukemogenesis by NUP98-IQCG
null
《医学前沿(英文)》 2016年 第10卷 第4期 页码 410-419 doi: 10.1007/s11684-016-0489-0
NUP98 fuses with approximately 34 different partner genes via translocation in hematological malignancies. Transgenic or retrovirus-mediated bone marrow transplanted mouse models reveal the leukemogenesis of some NUP98-related fusion genes. We previously reported the fusion protein NUP98-IQ motif containing G (IQCG) in a myeloid/T lymphoid bi-phenoleukemia patient with t(3;11) and confirmed its leukemogenic ability. Herein, we demonstrated the association of NUP98-IQCG with CRM1, and found that NUP98-IQCG expression inhibits the CRM1-mediated nuclear export of p65 and enhances the transcriptional activity of nuclear factor-κB. Moreover, IQCG could be entrapped in the nucleus by NUP98-IQCG, and the fusion protein interacts with calmodulin via the IQ motif in a calcium-independent manner. Therefore, the inhibition of nuclear exports of p65 and IQCG might contribute to the leukemogenesis of NUP98-IQCG.
Inhibition of NF-kappa B can enhance Fas-mediated apoptosis in leukemia cell line HL-60
Li WANG, Shi ZHAO, Hong-Xiang WANG, Ping ZOU
《医学前沿(英文)》 2010年 第4卷 第3期 页码 323-328 doi: 10.1007/s11684-010-0026-5
关键词: nuclear factor-kappa B Fas/FasL system HL-60 Bay 11-7082
Expression of STAT6 and NF-κB p65 in the colon mucosa of patients with ulcerative colitis
Rui ZHU MD, Heng FAN MD, Lin SHEN MD, Jianguo LIU BD, Jia ZHAO MM,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 475-479 doi: 10.1007/s11684-009-0086-6
关键词: ulcerative colitis signal transducer and activator of transcription 6 (STAT6) nuclear factor-κ B p65 (NF-κ B p65)
Effect of compound Sophorae Flavescentis Jiechangrong capsule on expression of NF-κB p65 and STAT6
Heng FAN MD, Jia ZHAO MM, Lin SHEN BM, Qing TANG MD, Zhexin SHOU MM, Li LIANG BM, Yi LIAO BM, Xiaoyan CHEN BM,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 480-484 doi: 10.1007/s11684-009-0083-9
关键词: colitis ulcerative compound Sophorae Flavescentis Jiechangrong capsule nuclear factor-κ B p65 (NF-κ B p65) signal transducer and activator of transcription 6 (STAT6)
Yang-ying Zhao, Fan-xin Kong, Zhi Wang, Hong-wei Yang, Xiao-mao Wang, Yuefeng F. Xie, T. David Waite
《环境科学与工程前沿(英文)》 2017年 第11卷 第6期 doi: 10.1007/s11783-017-0975-x
关键词: Trace organic compounds (TrOCs) Nanofiltration (NF) Adsorption Membrane properties Water treatment
陆继来,黄娟,王惠中,张利民,夏明芳,李月中,任洪强
《中国工程科学》 2008年 第10卷 第10期 页码 61-63
报告了采用膜生物反应器(MBR)—纳滤(NF)组合工艺处理高浓度垃圾渗滤液,该工艺充分发挥了MBR和NF单元的功能互补性,运行实践表明
Role of water chemistry on estrone removal by nanofiltration with the presence of hydrophobic acids
Xue JIN,Jiangyong HU
《环境科学与工程前沿(英文)》 2015年 第9卷 第1期 页码 164-170 doi: 10.1007/s11783-014-0747-9
关键词: indirect potable water reuse steroid hormone nanofiltration(NF) rejection water chemistry hydrophobic acids
Current hepatitis B treatment guidelines and future research directions
null
《医学前沿(英文)》 2014年 第8卷 第2期 页码 145-157 doi: 10.1007/s11684-014-0335-1
Hepatitis B virus (HBV) infection causes a tremendous clinical burden across the world with more than half a million people dying annually from HBV related disease. Significant advances have been made in HBV treatment in the past decade and several guidelines have been published by professional societies and expert panels. Although these recommendations have been valuable to help optimize HBV treatment, there is discordance in treatment criteria and many patients infected with HBV may fall outside of these recommendations. This paper systematically reviews the natural history of the disease and compares and contrasts the recommendations for initiation of treatment from the various societies. There is also discussion of special groups that require particular consideration and some of the open research questions and future research directions within the field.
关键词: chronic hepatitis B HBV treatment guidelines APASL guidelines EASL guidelines AASLD guidelines
《医学前沿(英文)》 2022年 第16卷 第1期 页码 111-125 doi: 10.1007/s11684-021-0854-5
关键词: COVID-19 chronic hepatitis B liver injury coagulation dysfunction
作为一种新的心肌细胞代谢改变和焦亡调节剂,CPAL可调节小鼠心肌梗死损伤 Article
李佳敏, 薛宏儒, 徐宁, 龚丽玲, 李鸣, 李思佳, 黄迪, 张庆伟, 李鹏宇, 李青穗, 于航, 刘伊宁, 薛亚东, 陈海鑫, 刘佳丽, 张万玉, 刘明彬, 常思雨, 郎宪治, 赵星淼, 杜伟杰, 蔡本志, 王宁, 杨宝峰
《工程(英文)》 2023年 第20卷 第1期 页码 49-62 doi: 10.1016/j.eng.2022.08.012
Vaccine therapies for chronic hepatitis B: can we go further?
null
《医学前沿(英文)》 2014年 第8卷 第1期 页码 17-23 doi: 10.1007/s11684-014-0313-7
Chronic hepatitis B is a major health burden worldwide. In addition to the recent progress in antiviral treatment, therapeutic vaccination is a promising new strategy for the control of chronic hepatitis B. On the basis of the major specific and non-specific immune dysregulations and defects in chronic hepatitis B patients, this paper presents the peptide and protein-based, DNA-based, cell-based, and antigen-antibody-based therapeutic vaccines, which have undergone clinical trials. The advantages, disadvantages, and future perspectives for these therapeutic vaccines are discussed.
关键词: chronic hepatitis B therapeutic antigen-antibody complexes DNA vaccine
Chronic hepatitis B virus infection: epidemiology, prevention, and treatment in China
null
《医学前沿(英文)》 2014年 第8卷 第2期 页码 135-144 doi: 10.1007/s11684-014-0331-5
Chronic hepatitis B is a major health problem in China. The universal vaccination program since 1992 has changed the epidemiology of hepatitis B virus infection in China from highly to moderately endemic. The most prevalent hepatitis B virus strains in China are genotypes B and C, whereas those in western provinces are genotypes D and C/D hybrid. Chronic hepatitis B poses a heavy burden to the society in China. Different treatment strategies have been explored to improve patient outcomes in a cost-effective manner. However, antiviral drugs with a low genetic barrier to resistance are still extensively used because of the generally low income and limited resources in China. Individualized antiviral therapy is closely associated with translational medicine, which utilizes information from studies on genomics, immune biomarkers, and fibrosis. The results of these studies are crucial in further improving treatment outcomes.
李伟,李强,王平
《中国工程科学》 2011年 第13卷 第1期 页码 56-61
基于概率断裂力学对B级钢货车侧架的圆角细节进行了模拟耐久性试验研究,提出了一种新的通用当量初始缺陷尺寸分布的计算方法,建立了裂纹超越概率模型
Impact analysis of compressor rotor blades of an aircraft engine
Y B SUDHIR SASTRY, B G KIROS, F HAILU, P R BUDARAPU
《结构与土木工程前沿(英文)》 2019年 第13卷 第3期 页码 505-514 doi: 10.1007/s11709-018-0493-3
关键词: axial flow compressor rotor and stator blades aircraft engine stress and impact analysis aluminum alloys
null
《医学前沿(英文)》 2014年 第8卷 第2期 页码 250-253 doi: 10.1007/s11684-014-0333-3
The clinical data of a patient with acute-on-chronic liver failure were analyzed retrospectively. The patient has suffered from hepatitis B for 30 years. His liver function deteriorated, yielding Child-Pugh grade C and reaching a model for end-stage liver disease score of 33 points within a short period; this condition was complicated with highly active variceal bleeding and coagulation system failure (PT > 100 s). The patient also presented hepatocellular carcinoma. Comprehensive treatments included effective inhibition of hepatitis B virus replication and intensive care support. Piggyback orthotopic liver transplantation was performed as the final treatment. The patient recovered uneventfully and was discharged after surgery.
关键词: acute-on-chronic liver failure submassive necrosis viral hepatitis B esophageal variceal bleeding liver transplantation
标题 作者 时间 类型 操作
Inhibition of NF-kappa B can enhance Fas-mediated apoptosis in leukemia cell line HL-60
Li WANG, Shi ZHAO, Hong-Xiang WANG, Ping ZOU
期刊论文
Expression of STAT6 and NF-κB p65 in the colon mucosa of patients with ulcerative colitis
Rui ZHU MD, Heng FAN MD, Lin SHEN MD, Jianguo LIU BD, Jia ZHAO MM,
期刊论文
Effect of compound Sophorae Flavescentis Jiechangrong capsule on expression of NF-κB p65 and STAT6
Heng FAN MD, Jia ZHAO MM, Lin SHEN BM, Qing TANG MD, Zhexin SHOU MM, Li LIANG BM, Yi LIAO BM, Xiaoyan CHEN BM,
期刊论文
Role of membrane and compound properties in affecting the rejection of pharmaceuticals by different RO/NF
Yang-ying Zhao, Fan-xin Kong, Zhi Wang, Hong-wei Yang, Xiao-mao Wang, Yuefeng F. Xie, T. David Waite
期刊论文
Role of water chemistry on estrone removal by nanofiltration with the presence of hydrophobic acids
Xue JIN,Jiangyong HU
期刊论文
Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center
期刊论文
作为一种新的心肌细胞代谢改变和焦亡调节剂,CPAL可调节小鼠心肌梗死损伤
李佳敏, 薛宏儒, 徐宁, 龚丽玲, 李鸣, 李思佳, 黄迪, 张庆伟, 李鹏宇, 李青穗, 于航, 刘伊宁, 薛亚东, 陈海鑫, 刘佳丽, 张万玉, 刘明彬, 常思雨, 郎宪治, 赵星淼, 杜伟杰, 蔡本志, 王宁, 杨宝峰
期刊论文
Impact analysis of compressor rotor blades of an aircraft engine
Y B SUDHIR SASTRY, B G KIROS, F HAILU, P R BUDARAPU
期刊论文