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The FGF metabolic axis

Xiaokun Li

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 511-530 doi: 10.1007/s11684-019-0711-y

Abstract: Members of the fibroblast growth factor (FGF) family play pleiotropic roles in cellular and metabolicDuring evolution, the ancestor FGF expands into multiple members by acquiring divergent structural elementsBy contrast, FGF19, 21, and 23 coevolve through losing binding affinity for extracellular matrix heparanFGF19 metabolic axis from the ileum to liver negatively controls diurnal bile acid biosynthesis.The significant divergence in structural elements and multiple functional specifications of FGF19, 21

Keywords： FGF19     FGF21     FGF23     FGFR     metabolism     endocrine     Klotho    

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FGF23 associated bone diseases

Eryuan Liao

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 65-80 doi: 10.1007/s11684-013-0254-6

Abstract:

Recently, fibroblast growth factor 23 (FGF23) has sparked widespread interest because of its potentialIn this review, we summarized the FGF superfamily, the mechanism of FGF23 on phosphate and vitamin Dmetabolism, and the FGF23 related bone disease.

Keywords： fibroblast growth factor 23     FGF receptor     phosphate metabolism     Klotho     bone disease    

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FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 896-908 doi: 10.1007/s11684-022-0944-z

Abstract: Fibroblast growth factor 13 (FGF13) is aberrantly expressed in multiple cancer types, suggesting itsResults showed that FGF13 was lowly expressed in patients with AML and that its elevated expression wasUnivariate and multivariate Cox regression analyses identified FGF13 as an independent prognostic factorA prognostic nomogram integrating FGF13 and clinicopathologic variables was constructed to predict 1-The xenograft study indicated that FGF13 overexpression prolonged the survival of recipient mice.

Keywords： acute myeloid leukemia     FGF13     prognosis     immune-related genes     bone marrow niches    

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Influence of retinoic acid on TBX1 expression in myocardial cells induced by Shh and Fgf8

Miao LIU, Xiaoyan WU, Jiawei XU, Runming JIN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 61-66 doi: 10.1007/s11684-009-0007-8

Abstract: The expression of Shh and Fgf8 at mRNA and protein levels in neonatal rat myocardial cells were measuredThere was basal expression of Shh and Fgf8 in the control group.Meanwhile, we could detect that the expression of Fgf8 mRNA and protein were up-regulated by 2.50 timesThe results indicated that RA could induce the expression of Shh and Fgf8 in neonatal rat myocardialAt the same time, it has shown that Shh and Fgf8 were involved in the regulation process of RA on TBX1

Keywords： retinoic acid     Tbx1 protein     Shh protein     Fgf8 protein    

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Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

Huating Li, Jing Zhang, Weiping Jia

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 25-30 doi: 10.1007/s11684-013-0244-8

Abstract:

Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor family.It is demonstrated that FGF21 acts on multiple tissue to coordinate carbohydrate and lipid metabolismMoreover, FGF21 also plays important roles in some physiological processes, such as fasting and feedingClinical relevance of FGF21 in humans is still unclear, and the basis and consequences of increased FGF21This article concentrates on recent advances in our understanding of FGF21.

Keywords： FGF21     metabolism     pharmacology     physiology     clinical relevance    

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A review of the safety and efficacy of current COVID-19 vaccines

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 39-55 doi: 10.1007/s11684-021-0893-y

Abstract: Vaccination is the most effective and feasible way to contain the coronavirus disease 2019 (COVID-19)The rapid development of effective COVID-19 vaccines is an extraordinary achievement.reviewed the efficacy/effectiveness, immunogenicity, and safety profile of the 12 most progressed COVID-19

Keywords： COVID-19     SARS-CoV-2     vaccine     safety     efficacy     effectiveness     immunogenicity    

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Innovation-driven trend shaping COVID-19 vaccine development in China

Frontiers of Medicine doi: 10.1007/s11684-023-1034-6

Abstract: Confronted with the coronavirus disease 2019 (COVID-19) pandemic, China has become an asset in tacklingprotein of SARS-CoV-2 or inactivated whole virus are a cornerstone of the public health response to COVID-19

Keywords： SARS-CoV-2     COVID-19 vaccine     vaccine development    

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SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 185-195 doi: 10.1007/s11684-021-0913-y

Abstract: genomic sequence with the world, has greatly facilitated the development of coronavirus disease (COVID-19combinations and immunization strategies to provide sufficient and sustainable immune protection against COVID-19

Keywords： COVID-19     pandemics     SARS-CoV-2     vaccination    

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Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function ofCD19-specific CAR T-cells via TGF-β signaling

Frontiers of Medicine doi: 10.1007/s11684-023-1010-1

Abstract: Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function ofCD19-specific CAR T-cells via TGF-β signaling

Keywords： exosomes induce activation     impair function CD19     exosomal CD19 antigen    

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Traditional Chinese medicine for combating COVID-19

Kaixian Chen, Hongzhuan Chen

Frontiers of Medicine 2020, Volume 14, Issue 5,   Pages 529-532 doi: 10.1007/s11684-020-0802-9

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Practice and principle of traditional Chinese medicine for the prevention and treatment of COVID-19

Frontiers of Medicine doi: 10.1007/s11684-023-1040-8

Abstract: TCM) has played an important role in the prevention and treatment of coronavirus disease 2019 (COVID-19The integration of Chinese and Western medicine is an important feature of Chinese COVID-19 preventionFor patients with mild and moderate forms of COVID-19, TCM can relieve the related signs and symptomsFor COVID-19 patients with severe and critical illnesses, TCM can improve inflammatory indicators andA series of mechanism research studies revealed that capability of TCM to treat COVID-19 through antiviral

Keywords： traditional Chinese medicine     COVID-19     SARS-CoV-2     clinical evidence-based study     mechanism     integrated    

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Preclinical characterization and comparison between CD3/CD19 bispecific and novel CD3/CD19/CD20 trispecific

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 139-149 doi: 10.1007/s11684-021-0835-8

Abstract: The CD19-targeting bispecific T-cell engager blinatumomab has shown remarkable efficacy in patients withmultiple trials have shown that approximately 30% of blinatumomab-relapsed cases are characterized by CD19Blinatumomab and A-319 are CD3/CD19 bispecific antibodies with different molecular sizes and structures, and A-2019 is a novel CD3/CD19/CD20 trispecific antibody with an additional anti-CD20 function., suggesting its potential function against CD19 weak or negative CD20 positive leukemic cells.

Keywords： B-cell acute lymphoblastic leukemia     bispecific antibody     trispecific antibody     CD19     CD20    

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COVID-19: why not learn from the past?

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 776-781 doi: 10.1007/s11684-021-0883-0

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Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 111-125 doi: 10.1007/s11684-021-0854-5

Abstract: The coronavirus disease 2019 (COVID-19) has spread globally.Although mixed liver impairment has been reported in COVID-19 patients, the association of liver injurycaused by specific subtype especially chronic hepatitis B (CHB) with COVID-19 has not been elucidatedmulti-center, retrospective, and observational cohort study, 109 CHB and 327 non-CHB patients with COVID-19In conclusion, COVID-19 patients with CHB were more likely to develop into severe illness and die.

Keywords： COVID-19     chronic hepatitis B     liver injury     coagulation dysfunction    

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Repercussions of COVID-19 pandemic on solid waste generation and management strategies

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 6, doi: 10.1007/s11783-021-1407-5

Abstract:

• Implication of COVID-19 on medical waste and MSW generation is studied

Keywords： COVID-19     Medical waste     Personal protective equipment     Municipal solid waste     Waste management    

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Title Author Date Type Operation

The FGF metabolic axis

Xiaokun Li

Journal Article

FGF23 associated bone diseases

Eryuan Liao

Journal Article

FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches

Journal Article

Influence of retinoic acid on TBX1 expression in myocardial cells induced by Shh and Fgf8

Miao LIU, Xiaoyan WU, Jiawei XU, Runming JIN

Journal Article

Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

Huating Li, Jing Zhang, Weiping Jia

Journal Article

A review of the safety and efficacy of current COVID-19 vaccines

Journal Article

Innovation-driven trend shaping COVID-19 vaccine development in China

Journal Article

SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic

Journal Article

Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function ofCD19-specific CAR T-cells via TGF-β signaling

Journal Article

Traditional Chinese medicine for combating COVID-19

Kaixian Chen, Hongzhuan Chen

Journal Article

Practice and principle of traditional Chinese medicine for the prevention and treatment of COVID-19

Journal Article

Preclinical characterization and comparison between CD3/CD19 bispecific and novel CD3/CD19/CD20 trispecific

Journal Article

COVID-19: why not learn from the past?

Journal Article

Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center

Journal Article

Repercussions of COVID-19 pandemic on solid waste generation and management strategies

Journal Article