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The FGF metabolic axis

Xiaokun Li

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 511-530 doi: 10.1007/s11684-019-0711-y

Abstract: Members of the fibroblast growth factor (FGF) family play pleiotropic roles in cellular and metabolicBy contrast, FGF19, 21, and 23 coevolve through losing binding affinity for extracellular matrix heparanFGF19 metabolic axis from the ileum to liver negatively controls diurnal bile acid biosynthesis.FGF21 metabolic axes play multifaceted roles in controlling the homeostasis of lipid, glucose, and energyThe significant divergence in structural elements and multiple functional specifications of FGF19, 21

Keywords： FGF19     FGF21     FGF23     FGFR     metabolism     endocrine     Klotho    

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Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

Huating Li, Jing Zhang, Weiping Jia

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 25-30 doi: 10.1007/s11684-013-0244-8

Abstract:

Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor family.It is demonstrated that FGF21 acts on multiple tissue to coordinate carbohydrate and lipid metabolismMoreover, FGF21 also plays important roles in some physiological processes, such as fasting and feedingClinical relevance of FGF21 in humans is still unclear, and the basis and consequences of increased FGF21Both the pharmacological actions and physiological roles make FGF21 attractive drug candidates for treating

Keywords： FGF21     metabolism     pharmacology     physiology     clinical relevance    

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FGF23 associated bone diseases

Eryuan Liao

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 65-80 doi: 10.1007/s11684-013-0254-6

Abstract:

Recently, fibroblast growth factor 23 (FGF23) has sparked widespread interest because of its potentialIn this review, we summarized the FGF superfamily, the mechanism of FGF23 on phosphate and vitamin Dmetabolism, and the FGF23 related bone disease.

Keywords： fibroblast growth factor 23     FGF receptor     phosphate metabolism     Klotho     bone disease    

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FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 896-908 doi: 10.1007/s11684-022-0944-z

Abstract: Fibroblast growth factor 13 (FGF13) is aberrantly expressed in multiple cancer types, suggesting itsResults showed that FGF13 was lowly expressed in patients with AML and that its elevated expression wasUnivariate and multivariate Cox regression analyses identified FGF13 as an independent prognostic factorA prognostic nomogram integrating FGF13 and clinicopathologic variables was constructed to predict 1-The xenograft study indicated that FGF13 overexpression prolonged the survival of recipient mice.

Keywords： acute myeloid leukemia     FGF13     prognosis     immune-related genes     bone marrow niches    

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Influence of retinoic acid on TBX1 expression in myocardial cells induced by Shh and Fgf8

Miao LIU, Xiaoyan WU, Jiawei XU, Runming JIN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 61-66 doi: 10.1007/s11684-009-0007-8

Abstract: The expression of Shh and Fgf8 at mRNA and protein levels in neonatal rat myocardial cells were measuredThere was basal expression of Shh and Fgf8 in the control group.Meanwhile, we could detect that the expression of Fgf8 mRNA and protein were up-regulated by 2.50 timesThe results indicated that RA could induce the expression of Shh and Fgf8 in neonatal rat myocardialAt the same time, it has shown that Shh and Fgf8 were involved in the regulation process of RA on TBX1

Keywords： retinoic acid     Tbx1 protein     Shh protein     Fgf8 protein    

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Orienting the Forest Remote Sensing of the 21st Century in China

Zhao Xianwen

Strategic Study of CAE 1999, Volume 1, Issue 3,   Pages 16-21

Abstract:

In the light of the mentioned above, the forest remote sensing perspective of the 21 st century

Keywords： forestry     remote sensing     developing of sustainable forestry     forestry towards the 21 st century    

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An Opinion on the Development of Oil and Gas Industry in the 21st Century

Chen Junwu

Strategic Study of CAE 2000, Volume 2, Issue 4,   Pages 21-24

Abstract:

The speed of international social-economic development closely depends upon the growth of world energy consumption, which in turn has to meet the stringent environmental protection policy that controls the total amount of greenhouse gas released to the atmosphere in the burning of fuel. In order to achieve the sustainable development of all nations, it is advisable to give an outlook to the future situation of world oil and gas industry as the representatives of the non-regenerable energy resources. This paper presents an opinion on the future development of oil and gas industry based on limited data published in literature together with controversial forecasts by different authors and covers four subjects： (1) the demand and supply of oil and gas in the new century; (2) the specifications of oil products to meet the environmental regulations; (3) the role of unconventional oil in the energy industry and (4) the brilliant future of natural gas.

Keywords： 21st centurey     petroleum     natural gas     oil and gas industry    

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Science and Technology in Human's Living and Survival in the 21st Century

Jiang Zhenghua

Strategic Study of CAE 2002, Volume 4, Issue 4,   Pages 1-11

Abstract:

This article, from the angle of management, reviews the world history over the past century, studies the prospective progress in the new century, and discusses ways for promoting world peace and cooperation and realizing common development.

Keywords： 21st century     progress in science and technology     human's living and survival    

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Digital manufacturing—the development direction of the manufacturing technology in the 21st century

XIONG You-lun, YIN Zhou-ping

Frontiers of Mechanical Engineering 2006, Volume 1, Issue 2,   Pages 125-130 doi: 10.1007/s11465-006-0021-3

Abstract: After introducing the concepts of digital manufacturing technology, the discipline framework of digital manufacturing is presented in the paper by discussing its basic concept, theory foundation, key technology and scientific problems in detail. As the core of the advanced manufacturing technology, digital manufacturing is gradually becoming the main manufacturing technology of the twenty-first century. Firstly, the main features of digital manufacturing are indicated and its key supporting technologies are investigated by grouping them into four levels related to product development, numerical control, production management, and enterprise collaboration, respectively. Moreover, the existing problems in the research on the multi-discipline theory foundation of digital manufacturing such as manufacturing informatics, computational manufacturing, and manufacturing intelligence, are also indicated. Then, the core scientific problems of digital manufacturing are discussed in depth, which focuses on digitization of manufacturing information, modeling of manufacturing constraints, high-speed and high-precision numerical control theory, and Internet-based collaboration and integration. Lastly, the development trends and application perspectives of digital manufacturing are concluded.

Keywords： development     foundation     multi-discipline     scientific     supporting    

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The Challenge of Computing and Information Technology in the 21st Century

Wm. A. Wulf

Strategic Study of CAE 2000, Volume 2, Issue 10,   Pages 9-12

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How diplomacy saved the COP21 Paris Climate Conference, but now, can we save ourselves?

D. Nathaniel MULCAHY, David L. MULCAHY

Frontiers in Energy 2018, Volume 12, Issue 3,   Pages 344-352 doi: 10.1007/s11708-017-0498-y

Abstract: The 2015 COP21 Paris accord was a masterful, perhaps even world-saving, diplomatic advance toward makingsome scientific truths, written specifically to be overlooked, were presented in order to prepare COP21

Keywords： COP21     Paris     climate     agreement     offsets     mitigation     IPCC    

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Silk Roads for the 21st Century: Engineering Mega-Infrastructure for Development and Sustainability

Tony Marjoram

Frontiers of Engineering Management 2016, Volume 3, Issue 3,   Pages 187-196 doi: 10.15302/J-FEM-2016038

Abstract: Mega infrastructure such as the Silk Road Economic Belt and 21st Century Maritime Silk Road, the “One

Keywords： infrastructure     growth     development     sustainability     change     new Silk Roads    

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Title Author Date Type Operation

The FGF metabolic axis

Xiaokun Li

Journal Article

Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

Huating Li, Jing Zhang, Weiping Jia

Journal Article

FGF23 associated bone diseases

Eryuan Liao

Journal Article

FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches

Journal Article

Influence of retinoic acid on TBX1 expression in myocardial cells induced by Shh and Fgf8

Miao LIU, Xiaoyan WU, Jiawei XU, Runming JIN

Journal Article

Orienting the Forest Remote Sensing of the 21st Century in China

Zhao Xianwen

Journal Article

An Opinion on the Development of Oil and Gas Industry in the 21st Century

Chen Junwu

Journal Article

Science and Technology in Human's Living and Survival in the 21st Century

Jiang Zhenghua

Journal Article

Digital manufacturing—the development direction of the manufacturing technology in the 21st century

XIONG You-lun, YIN Zhou-ping

Journal Article

The Challenge of Computing and Information Technology in the 21st Century

Wm. A. Wulf

Journal Article

Seminar on the Current Situation and Development Trend of New Materials in the 21st Century

Journal Article

How diplomacy saved the COP21 Paris Climate Conference, but now, can we save ourselves?

D. Nathaniel MULCAHY, David L. MULCAHY

Journal Article

Summary of the Symposium on the Current Situation and Development Trend of New Materials in the 21st

Journal Article

Silk Roads for the 21st Century: Engineering Mega-Infrastructure for Development and Sustainability

Tony Marjoram

Journal Article

Summary of the Symposium on the Current Situation and Development Trend of New Materials in the 21st

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Journal Article