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A post-GWAS replication study confirming the association of
Shaohua YANG,Chao QI,Yan XIE,Xiaogang CUI,Yahui GAO,Jianping JIANG,Li JIANG,Shengli ZHANG,Qin ZHANG,Dongxiao SUN
Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 4, Pages 321-330 doi: 10.15302/J-FASE-2014037
Keywords: GWAS functional annotation Chinese Holstein milk production traits C14H8orf33 gene single nucleotide
Genome-wide association studies: inherent limitations and future challenges
Yan Du, Jiaxin Xie, Wenjun Chang, Yifang Han, Guangwen Cao
Frontiers of Medicine 2012, Volume 6, Issue 4, Pages 444-450 doi: 10.1007/s11684-012-0225-3
Genome-wide association studies (GWAS) have achieved great success in identifying genetic variantsRecently, GWAS is quite the fashion in China.Enormous work needs to be done in the post-GWAS era.Along with pharmacogenomics, the success of GWAS in identifying genetic risk factors and genetic differences) as an example to demonstrate some of the inherent limitations and summarized future challenges of GWAS
Keywords: genome-wide association studies (GWAS) genetic variant cancer limitation challenge
A genome-wide association study of five meat quality traits in Yorkshire pigs
Qian DONG,Huiying LIU,Xinyun LI,Wei WEI,Shuhong ZHAO,Jianhua CAO
Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 2, Pages 137-143 doi: 10.15302/J-FASE-2014014
Keywords: Pig GWAS meat quality trait SNP
Caiyun LIU, Francisco PINTO, C. Mariano COSSANI, Sivakumar SUKUMARAN, Matthew P. REYNOLDS
Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 3, Pages 296-308 doi: 10.15302/J-FASE-2019269
Keywords: genome-wide association study (GWAS) heat tolerance spectral reflectance spring wheat
Twelve Years of Genome-Wide Association Studies of Human Protein N-Glycosylation Review
Anna Timoshchuk, Sodbo Sharapov, Yurii S. Aulchenko
Engineering 2023, Volume 26, Issue 7, Pages 17-31 doi: 10.1016/j.eng.2023.03.013
Most human-secreted and membrane-bound proteins have covalently attached oligosaccharide chains, or glycans. Glycosylation influences the physical and chemical properties of proteins, as well as their biological functions. Unsurprisingly, alterations in protein glycosylation have been implicated in a growing number of human diseases, and glycans are increasingly being considered as potential therapeutic targets, an essential part of therapeutics, and biomarkers. Although glycosylation pathways are biochemically well-studied, little is known about the networks of genes that guide the cell- and tissue-specific regulation of these biochemical reactions in humans in vivo. The lack of a detailed understanding of the mechanisms regulating glycome variation and linking the glycome to human health and disease is slowing progress in clinical applications of human glycobiology. Two of the tools that can provide much sought-after knowledge of human in vivo glycobiology are human genetics and genomics, which offer a powerful data-driven agnostic approach for dissecting the biology of complex traits. This review summarizes the current state of human populational glycogenomics. In Section 1, we provide a brief overview of the N-glycan's structural organization, and in Section 2, we give a description of the major blood plasma glycoproteins. Next, in Section 3, we summarize, systemize, and generalize the results from current N-glycosylation genome-wide association studies (GWASs) that provide novel knowledge of the genetic regulation of the populational variation of glycosylation. Until now, such studies have been limited to an analysis of the human blood plasma N-glycome and the N-glycosylation of immunoglobulin G and transferrin. While these three glycomes make up a rather limited set compared with the enormous multitude of glycomes of different tissues and glycoproteins, the study of these three does allow for powerful analysis and generalization. Finally, in Section 4, we turn to genes in the established loci, paying particular attention to genes with strong support in Section 5. At the end of the review, in Sections 6 and 7, we describe special cases of interest in light of new discoveries, focusing on possible mechanisms of action and biological targets of genetic variation that have been implicated in human protein N-glycosylation.
Keywords: Glycome Glycans N-glycosylation Genomics Genetics GWAS
Genetic Study Identifies CBLN4 as a Novel Susceptibility Gene for Accident Proneness
Shu-lin Zhang,Hui-qing Jin,Yang Song,Wan-sheng Yu,Liang-dan Sun
Frontiers of Engineering Management 2016, Volume 3, Issue 1, Pages 30-38 doi: 10.15302/J-FEM-2016008
Keywords: accident proneness genome-wide association study (GWAS) dopamine (DA) ACTH susceptibility gene traffic
Title Author Date Type Operation
A post-GWAS replication study confirming the association of
Shaohua YANG,Chao QI,Yan XIE,Xiaogang CUI,Yahui GAO,Jianping JIANG,Li JIANG,Shengli ZHANG,Qin ZHANG,Dongxiao SUN
Journal Article
Genome-wide association studies: inherent limitations and future challenges
Yan Du, Jiaxin Xie, Wenjun Chang, Yifang Han, Guangwen Cao
Journal Article
A genome-wide association study of five meat quality traits in Yorkshire pigs
Qian DONG,Huiying LIU,Xinyun LI,Wei WEI,Shuhong ZHAO,Jianhua CAO
Journal Article
Spectral reflectance indices as proxies for yield potential and heat stress tolerance in spring wheat: heritability estimates and marker-trait associations
Caiyun LIU, Francisco PINTO, C. Mariano COSSANI, Sivakumar SUKUMARAN, Matthew P. REYNOLDS
Journal Article
Twelve Years of Genome-Wide Association Studies of Human Protein N-Glycosylation
Anna Timoshchuk, Sodbo Sharapov, Yurii S. Aulchenko
Journal Article