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Keywords

Immunoglobulin G 5

N2O 4

n-heptane 4

CH4 3

CO2 3

Denitrification 3

Glycosylation 3

H7N9 3

N 2

N-nitrosodimethylamine 2

N-nitrosodimethylamine (NDMA) 2

C/N ratio 2

COD/N ratio 2

COVID-19 2

Capillary gel electrophoresis 2

Colorectal cancer 2

Denitrifying phosphorus removal 2

Greenhouse gas 2

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Removable Dyes—The Missing Link for In-Depth N-glycan Analysis via Multi-Method Approaches

Samanta Cajic,René Hennig,Valerian Grote,Udo Reichl,Erdmann Rapp,

Engineering doi: 10.1016/j.eng.2023.02.016

Abstract: As the roles of glycans in health and disease continue to be unraveled, it is becoming apparent thatglycans’ immense complexity cannot be ignored.Through the detailed structural analysis of selected, dauntingly complex N-glycans from chicken ovalbuminMoreover, this approach “visualizes” N-glycans that have been difficult to identify thus far—such asthe sulfated glycans on human immunoglobulin A—including minute changes in glycan structures, potentially

Keywords： Glycoproteins     N-glycans     Reversible labeling     Hydrophilic interaction liquid chromatography     Capillary gel    

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Removable Dyes—The Missing Link for In-Depth N-Glycan Analysis via Multi-Method Approaches Article

Samanta Cajic, René Hennig, Valerian Grote, Udo Reichl, Erdmann Rapp

Engineering 2023, Volume 26, Issue 7,   Pages 132-150 doi: https://doi.org/10.1016/j.eng.2023.02.016

Abstract:

As the roles of glycans in health and disease continue to be unraveled, it is becoming apparent thatglycans'  immense complexity cannot be ignored.Through the detailed structural analysis of selected, dauntingly complex N-glycans from chickenMoreover, this approach "visualizes" N-glycans that have been difficult to identifythus far—such as the sulfated glycans on human immunoglobulin A—including minute changes

Keywords： Glycoproteins     N-glycans     Reversible labeling     Hydrophilic interaction liquid chromatography     Capillary    

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Twelve Years of Genome-Wide Association Studies of Human Protein N-Glycosylation Review

Anna Timoshchuk, Sodbo Sharapov, Yurii S. Aulchenko

Engineering 2023, Volume 26, Issue 7,   Pages 17-31 doi: 10.1016/j.eng.2023.03.013

Abstract: Most human-secreted and membrane-bound proteins have covalently attached oligosaccharide chains, or glycansalterations in protein glycosylation have been implicated in a growing number of human diseases, and glycansIn Section 1, we provide a brief overview of the N-glycan's structural organization, andNext, in Section 3, we summarize, systemize, and generalize the results from current N-glycosylationand the N-glycosylation of immunoglobulin G and transferrin.

Keywords： Glycome     Glycans     N-glycosylation     Genomics     Genetics     GWAS    

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Human Prostate-Specific Antigen Carries N-Glycans with Ketodeoxynononic Acid Article

Wei Wang, Tao Zhang, Jan Nouta, Peter A. van Veelen, Noortje de Haan, Theo M. de Reijke, Manfred Wuhrer, Guinevere S.M. Lageveen-Kammeijer

Engineering 2023, Volume 26, Issue 7,   Pages 119-131 doi: 10.1016/j.eng.2023.02.009

Abstract: Here, we report for the first time that Kdn is expressed on prostate-specific antigen (PSA) N-linked glycans derived from human seminal plasma and urine.

Keywords： Ketodeoxynononic acid     Kdn     Glycosylation     Prostate cancer     Prostate-specific antigen    

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Spectrometry Analysis of Newly Emerging Coronavirus HCoV-19 Spike Protein and Human ACE2 Reveals Camouflaging Glycans Article

Zeyu Sun, Keyi Ren, Xing Zhang, Jinghua Chen, Zhengyi Jiang, Jing Jiang, Feiyang Ji, Xiaoxi Ouyang, Lanjuan Li

Engineering 2021, Volume 7, Issue 10,   Pages 1441-1451 doi: 10.1016/j.eng.2020.07.014

Abstract: 21 possible glycosites in the HCoV-19 spike protein (S protein), 20 are completely occupied by N-glycans, predominantly of the oligomannose type.angiotensin I converting enzyme 2 (hACE2) were found to be completely occupied, mainly by complex N-glycans.Refined structural models of HCoV-19 S protein and hACE2 were built by adding N-glycan and PTMs

Keywords： N-glycosylation     COVID-19     Spike protein     hACE2     Structure    

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Serum IgG Glycan Hallmarks of Systemic Lupus Erythematosus Article

Hudan Pan, Jingrong Wang, Yong Liang, Canjian Wang, Ruimin Tian, Hua Ye, Xiao Zhang, Yuanhao Wu, Miao Shao, Ruijun Zhang, Yao Xiao, Zhi Li, Guangfeng Zhang, Hua Zhou, Yilin Wang, Xiaoshuang Wang, Zhanguo Li, Wei Liu, Liang Liu

Engineering 2023, Volume 26, Issue 7,   Pages 89-98 doi: 10.1016/j.eng.2023.01.006

Abstract: Here, we identified two N-glycans on serum immunoglobulin G (IgG) as excellent diagnostic biomarkersThese two N-glycan biomarkers are specific for diagnosing SLE, as no significant changes inNotably, the two N-glycan biomarkers proved to be autoantibody-independent and all-stage patientThe two N-glycan biomarkers are demonstrated to be located on the Fc region based on fragment-specific

Keywords： Systemic lupus erythematosus     N-glycans     Diagnostic indicators    

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Effect of Cu-ZSM-5 catalysts with different CuO particle size on selective catalytic oxidation of N,N-Dimethylformamide

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 10, doi: 10.1007/s11783-022-1557-0

Abstract:

● A series of Cu-ZSM-5 catalysts were tested for DMF selective catalytic oxidation.

Keywords： N     N-Dimethylformamide     Selective catalytic oxidation     Cu-ZSM-5     CuO particle size    

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Enhancing the efficiency of nitrogen removing bacterial population to a wide range of C:N ratio (1.5:1 to 14:1) for simultaneous C & N removal

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 8, doi: 10.1007/s11783-022-1522-y

Abstract:

• Simultaneous C & N removal in Methammox occurs at wide C:N ratio.

Keywords： Methanogens     Biological Nitrogen Removal (BNR)     Simultaneous     Methammox     C:N ratio    

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CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a sweet success?

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 322-338 doi: 10.1007/s11684-021-0901-2

Abstract: Immune-based therapies have experienced a pronounced breakthrough in the past decades as they acquired multiple US Food and Drug Administration (FDA) approvals for various indications. To date, six chimeric antigen receptor T cell (CAR-T) therapies have been permitted for the treatment of certain patients with relapsed/refractory hematologic malignancies. However, several clinical trials of solid tumor CAR-T therapies were prematurely terminated, or they reported life-threatening treatment-related damages to healthy tissues. The simultaneous expression of target antigens by healthy organs and tumor cells is partly responsible for such toxicities. Alongside targeting tumor-specific antigens, targeting the aberrantly glycosylated glycoforms of tumor-associated antigens can also minimize the off-tumor effects of CAR-T therapies. Tn, T, and sialyl-Tn antigens have been reported to be involved in tumor progression and metastasis, and their expression results from the dysregulation of a series of glycosyltransferases and the endoplasmic reticulum protein chaperone, Cosmc. Moreover, these glycoforms have been associated with various types of cancers, including prostate, breast, colon, gastric, and lung cancers. Here, we discuss how underglycosylated antigens emerge and then detail the latest advances in the development of CAR-T-based immunotherapies that target some of such antigens.

Keywords： immunotherapy     chimeric antigen receptor     solid tumors     tumor-associated antigen     glycosylation     O-glycans    

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Effect of fly ash and slag on concrete: Properties and emission analyses

TAM, Khoa N. LE, Ana Catarina Jorge EVANGELISTA, Anthony BUTERA, Cuong N. N. TRAN, Ashraf TEARA

Frontiers of Engineering Management 2019, Volume 6, Issue 3,   Pages 395-405 doi: 10.1007/s42524-019-0019-2

Abstract: Recycled concrete is a material with the potential to create a sustainable construction industry. However, recycled concrete presents heterogeneous properties, thereby reducing its applications for some structural purposes and enhancing its application in pavements. This paper provides an insight into a solution in the deformation control for recycled concrete by adding supplementary cementitious materials fly ash and blast furnace slag. Results of this study indicated that the 50% fly ash replacement of Portland cement increased the rupture modulus of the recycled concrete. Conversely, a mixture with over 50% cement replacement by either fly ash or slag or a combination of both exhibited detrimental effect on the compressive strength, rupture modulus, and drying shrinkage. The combined analysis of environmental impacts and mechanical properties of recycled concrete demonstrated the possibility of optimizing the selection of recycled concrete because the best scenario in this study was obtained with the concrete mixture M8 (50% of fly ash+ 100% recycled coarse aggregate).

Keywords： recycled aggregate     recycled concrete     fly ash and slag    

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Endemicity of H9N2 and H5N1 avian influenza viruses in poultry in China poses a serious threat to poultry

Jiao HU,Xiufan LIU

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 1,   Pages 11-24 doi: 10.15302/J-FASE-2016092

Abstract: The H9N2 and H5N1 avian influenza viruses (AIVs) have been circulating in poultry in China and becomeinfluenza viruses, such as the well-known viruses of the highly pathogenic avian influenza (HPAI) H5N2and the 2013 novel H7N7, H7N9 and H10N8 subtypes, thereby threatening both the poultry industry and

Keywords： avian influenza virus     H9N2     H5N1     novel viruses     public health    

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CO, N, and CO/N mixed gas injection for enhanced shale gas recovery and CO geological storage

Frontiers in Energy 2023, Volume 17, Issue 3,   Pages 428-445 doi: 10.1007/s11708-023-0865-9

Abstract: the adsorption capacity of CO2 was the largest, followed by CH4, and that of N2 was longer than that of N<>) was also higher than that of N4 of N<N2 breakthrough.

Keywords： shale gas     gas injection     competitive adsorption     enhanced shale gas recovery     CO2 geological storage    

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The performance of nitrate-reducing Fe(II) oxidation processes under variable initial Fe/N ratios: The

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 4, doi: 10.1007/s11783-020-1366-2

Abstract:

•Bacterially-mediated coupled N and Fe processes examined in incubation

Keywords： Denitrification     N2O emission     Fe(II) oxidation     Fe/N ratio     Fe minerals    

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Reuse of N95 Masks

Dana Mackenzie

Engineering 2020, Volume 6, Issue 6,   Pages 593-596 doi: 10.1016/j.eng.2020.04.003

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Physiological functions and clinical implications of the N-end rule pathway

Yujiao Liu,Chao Liu,Wen Dong,Wei Li

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 258-270 doi: 10.1007/s11684-016-0458-7

Abstract:

The N-end rule pathway is a unique branch of the ubiquitin-proteasome system in which the determinationof a protein’s half-life is dependent on its N-terminal residue.The N-terminal residue serves as the degradation signal of a protein and thus called N-degron.N-degron can be recognized and modifed by several steps of post-translational modifications, such asoxidation, deamination, arginylation or acetylation, it then polyubiquitinated by the N-recognin for

Keywords： N-end rule pathway     Ate1     cardiovascular development     neurogenesis     spermatogenesis     neurodegenerative disorders    

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Title Author Date Type Operation

Removable Dyes—The Missing Link for In-Depth N-glycan Analysis via Multi-Method Approaches

Samanta Cajic,René Hennig,Valerian Grote,Udo Reichl,Erdmann Rapp,

Journal Article

Removable Dyes—The Missing Link for In-Depth N-Glycan Analysis via Multi-Method Approaches

Samanta Cajic, René Hennig, Valerian Grote, Udo Reichl, Erdmann Rapp

Journal Article

Twelve Years of Genome-Wide Association Studies of Human Protein N-Glycosylation

Anna Timoshchuk, Sodbo Sharapov, Yurii S. Aulchenko

Journal Article

Human Prostate-Specific Antigen Carries N-Glycans with Ketodeoxynononic Acid

Wei Wang, Tao Zhang, Jan Nouta, Peter A. van Veelen, Noortje de Haan, Theo M. de Reijke, Manfred Wuhrer, Guinevere S.M. Lageveen-Kammeijer

Journal Article

Spectrometry Analysis of Newly Emerging Coronavirus HCoV-19 Spike Protein and Human ACE2 Reveals Camouflaging Glycans

Zeyu Sun, Keyi Ren, Xing Zhang, Jinghua Chen, Zhengyi Jiang, Jing Jiang, Feiyang Ji, Xiaoxi Ouyang, Lanjuan Li

Journal Article

Serum IgG Glycan Hallmarks of Systemic Lupus Erythematosus

Hudan Pan, Jingrong Wang, Yong Liang, Canjian Wang, Ruimin Tian, Hua Ye, Xiao Zhang, Yuanhao Wu, Miao Shao, Ruijun Zhang, Yao Xiao, Zhi Li, Guangfeng Zhang, Hua Zhou, Yilin Wang, Xiaoshuang Wang, Zhanguo Li, Wei Liu, Liang Liu

Journal Article

Effect of Cu-ZSM-5 catalysts with different CuO particle size on selective catalytic oxidation of N,N-Dimethylformamide

Journal Article

Enhancing the efficiency of nitrogen removing bacterial population to a wide range of C:N ratio (1.5:1 to 14:1) for simultaneous C & N removal

Journal Article

CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a sweet success?

Journal Article

Effect of fly ash and slag on concrete: Properties and emission analyses

TAM, Khoa N. LE, Ana Catarina Jorge EVANGELISTA, Anthony BUTERA, Cuong N. N. TRAN, Ashraf TEARA

Journal Article

Endemicity of H9N2 and H5N1 avian influenza viruses in poultry in China poses a serious threat to poultry

Jiao HU,Xiufan LIU

Journal Article

CO, N, and CO/N mixed gas injection for enhanced shale gas recovery and CO geological storage

Journal Article

The performance of nitrate-reducing Fe(II) oxidation processes under variable initial Fe/N ratios: The

Journal Article

Reuse of N95 Masks

Dana Mackenzie

Journal Article

Physiological functions and clinical implications of the N-end rule pathway

Yujiao Liu,Chao Liu,Wen Dong,Wei Li

Journal Article