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Frontiers of Engineering Management Pages 67-81 doi: 10.1007/s42524-022-0240-2
Keywords: logistics network design post-disruption response strategy two-stage stochastic programming conditional
Modeling of the resilient supply chain system from a perspective of production design changes
Frontiers of Engineering Management Pages 96-106 doi: 10.1007/s42524-022-0235-z
Keywords: resilient supply chain supply chain disruption domain modeling product design changes
Evaluation of endocrine disruption and dioxin-like effects of organic extracts from sewage sludge in
LIU Cao,XU Yiping,MA Mei,HUANG Bingbin,WU Jingdong,MENG Qingyi,WANG Zijian,GEARHEART Robert Alan
Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 3, Pages 433-440 doi: 10.1007/s11783-013-0594-0
Keywords: sewage sludge in vitro bioassay endocrine disruption dioxin-like effect
Shen Huang,Xudong Feng,Chun Li
Frontiers of Chemical Science and Engineering 2015, Volume 9, Issue 4, Pages 501-510 doi: 10.1007/s11705-015-1544-0
Keywords: β-glucuronidase glycyrrhetic acid monoglucuronide cell disruption purification chromatography
CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells
Yongping Zhang, Xingying Zhang, Chen Cheng, Wei Mu, Xiaojuan Liu, Na Li, Xiaofei Wei, Xiang Liu, Changqing Xia, Haoyi Wang
Frontiers of Medicine 2017, Volume 11, Issue 4, Pages 554-562 doi: 10.1007/s11684-017-0543-6
T cells engineered with chimeric antigen receptor (CAR) have been successfully applied to treat advanced refractory B cell malignancy. However, many challenges remain in extending its application toward the treatment of solid tumors. The immunosuppressive nature of tumor microenvironment is considered one of the key factors limiting CAR-T efficacy. One negative regulator of T cell activity is lymphocyte activation gene-3 (LAG-3). We successfully generated LAG-3 knockout T and CAR-T cells with high efficiency using CRISPR-Cas9 mediated gene editing and found that the viability and immune phenotype were not dramatically changed during in vitro culture. LAG-3 knockout CAR-T cells displayed robust antigen-specific antitumor activity in cell culture and in murine xenograft model, which is comparable to standard CAR-T cells. Our study demonstrates an efficient approach to silence immune checkpoint in CAR-T cells via gene editing.
Keywords: CAR-T CRISPR-Cas9 LAG-3
Wan N. A. Kadir, Man K. Lam, Yoshimitsu Uemura, Jun W. Lim, Peck L. Kiew, Steven Lim, Siti S. Rosli, Chung Y. Wong, Pau L. Show, Keat T. Lee
Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 5, Pages 1257-1268 doi: 10.1007/s11705-020-2015-9
Keywords: microalgae biodiesel ozonation pre-treatment lipid
Airline Disruption Management: A Review of Models and Solution Methods Review
Yi Su, Kexin Xie, Hongjian Wang, Zhe Liang, Wanpracha Art Chaovalitwongse, Panos M. Pardalos
Engineering 2021, Volume 7, Issue 4, Pages 435-447 doi: 10.1016/j.eng.2020.08.021
Keywords: Disruption management Aircraft recovery problem Crew recovery problem Integrated recovery problem
Metro train rescheduling by adding backup trains under disrupted scenarios
Jiateng YIN, Yihui WANG, Tao TANG, Jing XUN, Shuai SU
Frontiers of Engineering Management 2017, Volume 4, Issue 4, Pages 418-427 doi: 10.15302/J-FEM-2017044
Keywords: train rescheduling backup train metro line disruption timetable
Omnichannel retail operations with ship-to-store and ship-from-store options under supply disruption
Frontiers of Engineering Management Pages 158-170 doi: 10.1007/s42524-022-0238-9
Keywords: supply chain disruption omnichannel fulfillment option ship-from-store ship-to-store
Tingting Wang, Jianfeng Wang, Xiangzhu Xu, Fan Jiang, Hongfa Lv, Qinghui Qi, Can Zhang, Qianghua Lv, Xuming Deng
Engineering 2023, Volume 28, Issue 9, Pages 206-221 doi: 10.1016/j.eng.2023.03.006
Keywords: Host-directed therapy Kaempferol ADAM10 inhibitor Staphylococcus aureus infection Barrier disruption
Title Author Date Type Operation
Two-stage stochastic programming with robust constraints for the logistics network post-disruption response
Journal Article
Modeling of the resilient supply chain system from a perspective of production design changes
Journal Article
Evaluation of endocrine disruption and dioxin-like effects of organic extracts from sewage sludge in
LIU Cao,XU Yiping,MA Mei,HUANG Bingbin,WU Jingdong,MENG Qingyi,WANG Zijian,GEARHEART Robert Alan
Journal Article
CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells
Yongping Zhang, Xingying Zhang, Chen Cheng, Wei Mu, Xiaojuan Liu, Na Li, Xiaofei Wei, Xiang Liu, Changqing Xia, Haoyi Wang
Journal Article
Simultaneous harvesting and cell disruption of microalgae using ozone bubbles: optimization and characterization
Wan N. A. Kadir, Man K. Lam, Yoshimitsu Uemura, Jun W. Lim, Peck L. Kiew, Steven Lim, Siti S. Rosli, Chung Y. Wong, Pau L. Show, Keat T. Lee
Journal Article
Airline Disruption Management: A Review of Models and Solution Methods
Yi Su, Kexin Xie, Hongjian Wang, Zhe Liang, Wanpracha Art Chaovalitwongse, Panos M. Pardalos
Journal Article
Metro train rescheduling by adding backup trains under disrupted scenarios
Jiateng YIN, Yihui WANG, Tao TANG, Jing XUN, Shuai SU
Journal Article
Omnichannel retail operations with ship-to-store and ship-from-store options under supply disruption
Journal Article
Liang Zhe: Airline Disruption Management: A Review of Models and Solution Methods(2021-11-9)
6 Jan 2022
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