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The regulatory sciences for stem cell-based medicinal products

Bao-Zhu Yuan,Junzhi Wang

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 190-200 doi: 10.1007/s11684-014-0323-5

Abstract:

Over the past few years, several new achievements have been made from stem cell studies, many of which have moved up from preclinical stages to early, or from early to middle or late, stages thanks to relatively safe profile and preliminary evidence of effectiveness. Moreover, some stem cell-based products have been approved for marketing by different national regulatory authorities. However, many critical issues associated mainly with incomplete understanding of stem cell biology and the relevant risk factors, and lack of effective regulations still exist and need to be urgently addressed, especially in countries where establishment of appropriate regulatory system just commenced. More relevantly, the stem cell regulatory sciences need to be established or improved to more effectively evaluate quality, safety and efficacy of stem cell products, and for building up the appropriate regulatory framework. In this review, we summarize some new achievements in stem cell studies, especially the preclinical and clinical studies, the existing regulations, and the associated challenges, and we then propose some considerations for improving stem cell regulatory sciences with a goal of promoting the steadfast growth of the well-regulated stem cell therapies abreast of evolvement of stem cell sciences and technologies.

Keywords： stem cell-based medicinal products (SCMPs)     stem cell therapy (SCT)     safety     effectiveness     standards     guidelines    

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IN VITRO ACTIVITY OF EXTRACTS OF FIVE MEDICINAL PLANT SPECIES ON PLANT PATHOGENIC FUNGI

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 4,   Pages 635-644 doi: 10.15302/J-FASE -2020343

Abstract:

The antifungal effectiveness of extracts of five medicinal plant species was determined.

Keywords： Botrytis cinerea / food preservation / plant diseases / plant pathogenic fungi / Tupistra chinensis    

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An introduction to the medicinal plant genome project

Shilin Chen, Li Xiang, Xu Guo, Qiushi Li

Frontiers of Medicine 2011, Volume 5, Issue 2,   Pages 178-184 doi: 10.1007/s11684-011-0131-0

Abstract: However, very few studies have been carried out on genomics for medicinal plants.This paper introduces the genome research of medicinal plants, including genome sequencing, assembly,

Keywords： genomics     medicinal plant     sequencing     application    

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ACTIVITY OF EXTRACTS OF FIVE MEDICINAL PLANT SPECIES ON PLANT PATHOGENIC FUNGI

Shufeng YAO, Jiali XU, Haibo ZHANG, Hong GAO, Shibin SHANG, Dan WANG

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 4,   Pages 635-644 doi: 10.15302/J-FASE-2020343

Abstract: The antifungal effectiveness of extracts of five medicinal plant species was determined.

Keywords： Botrytis cinerea     food preservation     plant diseases     plant pathogenic fungi     Tupistra chinensis    

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Antifungal and antibacterial functions of medicinal leech recombinant destabilase-lysozyme and its heated-up

T. G. YUDINA, Danyang GUO, N. F. PISKUNKOVA, I. B. PAVLOVA, L. L. ZAVALOVA, I. P. BASKOVA

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 2,   Pages 203-209 doi: 10.1007/s11705-012-1277-2

Abstract: Antifungal activity of recombinant medicinal leech destabilase-lysozyme (rec.Dest-Lys) was investigated

Keywords： recombinant destabilase-lysozyme (rec.Dest-Lys)     antimicrobial activity     antifungal activity     medicinal    

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Optimizing hairy root production from explants of

Zhaogui YAN, Shengyu LIU, Junlian ZHANG, Guan HUANG, Lijun DUAN, Yaomei YE

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 4,   Pages 513-522 doi: 10.15302/J-FASE-2019272

Abstract:

is a shrub that has been used in traditional herbal medicine. It has great pharmaceutical potential for treating diseases such as cancer and diabetes. As a prerequisite for propagation of this species on a large scale, hairy roots in were induced using and various factors affecting hairy root induction and growth evaluated. Seven factors were tested: (1) type of explant, (2) type of culture medium, (3) duration of pre-culture, (4) inoculum cell density, (5) duration of infection, (6) acetosyringone concentration in the culture medium, and (7) duration of incubation. The optimal protocol for hairy root induction and growth was: young shoots, pre-cultured in Y1 for 2 d, inoculated with broth with an OD of 0.6 for 20 min, and incubated for 3 d. Putative transgenic hairy roots were initially identified by morphology and then confirmed by polymerase chain reaction. Successful and optimal production of hairy roots is a critical prerequisite for industrial scale clonal propagation of . Being able to cultivate the plant on a large scale will provide rapid and ready supply of the plant materials that can be used in herbal medicine and in scientific and industrial exploitation.

Keywords： hairy root induction     medicinal plant     MS growth medium     Phyllanthus hainanensis     Rhizobium rhizogenes    

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The Globalization of Traditional Medicines: Perspectives Related to the European Union Regulatory Environment Perspective

Werner Knoess, Jacqueline Wiesner

Engineering 2019, Volume 5, Issue 1,   Pages 22-31 doi: 10.1016/j.eng.2018.11.012

Abstract:

In the Member States of the European Union (EU), a harmonized legislation on medicinal products hasbeen enforced, which specifically defines herbal medicinal products and traditional herbal medicinalto create a regulatory environment that takes into account the particular characteristics of herbal medicinalThe standards defined by the EU herbal monographs of the Committee on Herbal Medicinal Products (HMPC

Keywords： Traditional medicine     Traditional Chinese medicine     Committee on Herbal Medicinal Products     Herbal medicines    

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Strategies of CFSM Green & Circular Development Research in the Qinba Mountain Area

Liu Xu,Mei Xurong,Yang Zhengli and Yang Shiqi

Strategic Study of CAE 2016, Volume 18, Issue 5,   Pages 24-30 doi: 10.15302/J-SSCAE-2016.05.004

Abstract: build the green & circular development system for the crop farming, forestry, stock farming and medicinal

Keywords： the Qinba Mountain Area     crop farming     forestry     stock farming and medicinal materials (CFSM)     the green    

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A Comparative Analysis of the Chloroplast Genomes of Four Salvia Medicinal Plants Article

Conglian Liang, Lei Wang, Juan Lei, Baozhong Duan, Weisi Ma, Shuiming Xiao, Haijun Qi, Zhen Wang, Yaoqi Liu, Xiaofeng Shen, Shuai Guo, Haoyu Hu, Jiang Xu, Shilin Chen

Engineering 2019, Volume 5, Issue 5,   Pages 907-915 doi: 10.1016/j.eng.2019.01.017

Abstract: Salvia Linn. is a large genus of Labiatae that includes important medicinal plants.species identification, phylogenetic evolution, and cp genetic engineering studies of Salvia medicinal

Keywords： Salvia     Chloroplast genome     Comparative analysis    

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Solomon P Wasser: medicinal use of mushroom (2019-9-19)

Solomon P Wasser(高级职称)

20 Jan 2021

Keywords： 农业科学    

Title Author Date Type Operation

The regulatory sciences for stem cell-based medicinal products

Bao-Zhu Yuan,Junzhi Wang

Journal Article

IN VITRO ACTIVITY OF EXTRACTS OF FIVE MEDICINAL PLANT SPECIES ON PLANT PATHOGENIC FUNGI

Journal Article

An introduction to the medicinal plant genome project

Shilin Chen, Li Xiang, Xu Guo, Qiushi Li

Journal Article

ACTIVITY OF EXTRACTS OF FIVE MEDICINAL PLANT SPECIES ON PLANT PATHOGENIC FUNGI

Shufeng YAO, Jiali XU, Haibo ZHANG, Hong GAO, Shibin SHANG, Dan WANG

Journal Article

Antifungal and antibacterial functions of medicinal leech recombinant destabilase-lysozyme and its heated-up

T. G. YUDINA, Danyang GUO, N. F. PISKUNKOVA, I. B. PAVLOVA, L. L. ZAVALOVA, I. P. BASKOVA

Journal Article

Optimizing hairy root production from explants of

Zhaogui YAN, Shengyu LIU, Junlian ZHANG, Guan HUANG, Lijun DUAN, Yaomei YE

Journal Article

The Globalization of Traditional Medicines: Perspectives Related to the European Union Regulatory Environment

Werner Knoess, Jacqueline Wiesner

Journal Article

Strategies of CFSM Green & Circular Development Research in the Qinba Mountain Area

Liu Xu,Mei Xurong,Yang Zhengli and Yang Shiqi

Journal Article

Li Yu: The History and Development of Medicinal Bacteria in China (2019-9-19)

李玉(院士)

20 Jan 2021

Conference Videos

A Comparative Analysis of the Chloroplast Genomes of Four Salvia Medicinal Plants

Conglian Liang, Lei Wang, Juan Lei, Baozhong Duan, Weisi Ma, Shuiming Xiao, Haijun Qi, Zhen Wang, Yaoqi Liu, Xiaofeng Shen, Shuai Guo, Haoyu Hu, Jiang Xu, Shilin Chen

Journal Article

Solomon P Wasser: medicinal use of mushroom (2019-9-19)

Solomon P Wasser(高级职称)

20 Jan 2021

Conference Videos