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A novel variant in the gene in a large Chinese family with a unique phenotype of Clouston syndrome
Frontiers of Medicine 2023, Volume 17, Issue 2, Pages 330-338 doi: 10.1007/s11684-022-0933-2
Keywords: Clouston syndrome whole exome sequencing GJB6 gene novel variant unique phenotype
Heterogeneity of chronic obstructive pulmonary disease: from phenotype to genotype
Xu Chen, Xiaomao Xu, Fei Xiao
Frontiers of Medicine 2013, Volume 7, Issue 4, Pages 425-432 doi: 10.1007/s11684-013-0295-x
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality throughout the world and is mainly characterized by persistent airflow limitation. Given that multiple systems other than the lung can be impaired in COPD patients, the traditional FEV1/FVC ratio shows many limitations in COPD diagnosis and assessment. Certain heterogeneities are found in terms of clinical manifestations, physiology, imaging findings, and inflammatory reactions in COPD patients; thus, phenotyping can provide effective information for the prognosis and treatment. However, phenotypes are often based on symptoms or pathophysiological impairments in late-stage COPD, and the role of phenotypes in COPD prevention and early diagnosis remains unclear. This shortcoming may be overcome by the potential genotypes defined by the heterogeneities in certain genes. This review briefly describes the heterogeneity of COPD, with focus on recent advances in the correlations between genotypes and phenotypes. The potential roles of these genotypes and phenotypes in the molecular mechanisms and management of COPD are also elucidated.
Keywords: chronic obstructive pulmonary disease heterogeneity phenotype genotype prediction
Effects of iron oxide nanoparticles on phenotype and metabolite changes in hemp clones ( L.)
Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 10, doi: 10.1007/s11783-022-1569-9
● Fe3O4 NPs increased the biomass and chlorophyll content of hemp clones.
Keywords: Fe3O4 nanoparticle Hemp Growth enhancement THC Metabolite
Xuezhong Zhou,Yubing Li,Yonghong Peng,Jingqing Hu,Runshun Zhang,Liyun He,Yinghui Wang,Lijie Jiang,Shiyan Yan,Peng Li,Qi Xie,Baoyan Liu
Frontiers of Medicine 2014, Volume 8, Issue 3, Pages 337-346 doi: 10.1007/s11684-014-0349-8
Keywords: personalized medicine complex network clinical phenotype network traditional Chinese medicine
Frontiers of Medicine 2022, Volume 16, Issue 3, Pages 403-415 doi: 10.1007/s11684-021-0858-1
Keywords: myeloproliferative neoplasms IRF4 IRF8 hydroxyurea essential thrombocythemia
Changes of phenotype and function of human CD4 CD25 T cells induced by transfection of Foxp3
WU Kui, BI Yutian, WANG Yaoli, WANG Changzheng
Frontiers of Medicine 2008, Volume 2, Issue 4, Pages 366-369 doi: 10.1007/s11684-008-0070-6
Chen Wei
Strategic Study of CAE 2024, Volume 26, Issue 4, Pages 186-189 doi: 10.15302/J-SSCAE-2024.04.024
Heredity underlies the stability of an organism’s fundamental phenotype
Keywords: Flag Biology heredity phenotype
Natural killer cells in liver diseases
Meijuan Zheng, Haoyu Sun, Zhigang Tian
Frontiers of Medicine 2018, Volume 12, Issue 3, Pages 269-279 doi: 10.1007/s11684-018-0621-4
The liver has been characterized as a frontline lymphoid organ with complex immunological features such as liver immunity and liver tolerance. Liver tolerance plays an important role in liver diseases including acute inflammation, chronic infection, autoimmune disease, and tumors. The liver contains a large proportion of natural killer (NK) cells, which exhibit heterogeneity in phenotypic and functional characteristics. NK cell activation, well known for its role in the immune surveillance against tumor and pathogen-infected cells, depends on the balance between numerous activating and inhibitory signals. In addition to the innate direct “killer” functions, NK cell activity contributes to regulate innate and adaptive immunity (helper or regulator). Under the setting of liver diseases, NK cells are of great importance for stimulating or inhibiting immune responses, leading to either immune activation or immune tolerance. Here, we focus on the relationship between NK cell biology, such as their phenotypic features and functional diversity, and liver diseases.
Keywords: natural killer cell phenotype immune activation immune tolerance liver diseases
Genetics analysis of haptoglobin gene in Fujian Han nationality
ZOU Qilian, LIN Ying, LIN Xiangquan, CHEN Yuanzhong
Frontiers of Medicine 2008, Volume 2, Issue 1, Pages 105-107 doi: 10.1007/s11684-008-0019-9
Keywords: different haptoglobin phenotype frequency electrophoresis middle
Hong-Yun Zhang,Wei-Dan Jiang,Pei Wu,Yang Liu,Hong-Mei Ren,Xiao-Wan Jin,Xiao-Qiu Zhou,Lin Feng,
Engineering doi: 10.1016/j.eng.2024.03.016
Keywords: Zearalenone Natural products Phenotype-based screening Transcriptome analysis Fraxetin
Qiu Quan: Research on High Throughput Phenotype Acquisition Robot (2020-8-18)
17 Oct 2022
Keywords: 农业科学
Jingshu Gao, Hongli Ma, Yu Wang, Xinming Yang, Yijuan Cao, Bei Zhang, Conghui Han, Xiaoke Wu
Engineering 2021, Volume 7, Issue 2, Pages 170-177 doi: 10.1016/j.eng.2020.12.006
Genetic, lifestyle, and environmental factors contribute to the etiology of polycystic ovary syndrome (PCOS). Increased body mass index (BMI) exacerbates the reproductive and metabolic parameters and reduces the fecundity of women with PCOS. This is a secondary analysis of a large-sample, multicenter, randomized controlled trial conducted at 21 sites in Chinese mainland. A total of 1000 women diagnosed with PCOS were enrolled in this trial. Of these, 998 women with PCOS were included in the analysis. Increased BMI was associated with more severe menstrual irregularities, elevated testosterone level, higher prevalence of metabolic syndrome, and poorer quality of life. The rates of ovulation per woman for the normal, overweight, and obese BMI groups were 83.0%, 78.2%, and 63.6%, respectively (P < 0.001), and the rates of live birth were 23.6%, 18.1%, and 15.3% (P = 0.030). Northern PCOS patients showed more severe reproductive, glucose, and lipid profiles; less exercise; and lower total ovulation rates compared with PCOS patients from Southern China (74.8% vs 81.2%, absolute difference 6.4%, 95% confidence interval 1.2%–11.5%). The results show the typical phenotypic features of Han women with PCOS in Northern and Southern China. The women living in Northern China showed a higher BMI, more severe glycolipid metabolism profiles, and subsequently worse clinical outcomes by the same interventions than those living in Southern China. The difference in phenotypic features can be explained mostly by differences in BMI and the resulting difference in ovulation.
Keywords: Polycystic ovary syndrome Body mass index Phenotype Chinese cohort Geographic distribution
Title Author Date Type Operation
A novel variant in the gene in a large Chinese family with a unique phenotype of Clouston syndrome
Journal Article
Heterogeneity of chronic obstructive pulmonary disease: from phenotype to genotype
Xu Chen, Xiaomao Xu, Fei Xiao
Journal Article
Effects of iron oxide nanoparticles on phenotype and metabolite changes in hemp clones ( L.)
Journal Article
Clinical phenotype network: the underlying mechanism for personalized diagnosis and treatment of traditional
Xuezhong Zhou,Yubing Li,Yonghong Peng,Jingqing Hu,Runshun Zhang,Liyun He,Yinghui Wang,Lijie Jiang,Shiyan Yan,Peng Li,Qi Xie,Baoyan Liu
Journal Article
IRF4 and IRF8 expression are associated with clinical phenotype and clinico-hematological response to
Journal Article
Changes of phenotype and function of human CD4 CD25 T cells induced by transfection of Foxp3
WU Kui, BI Yutian, WANG Yaoli, WANG Changzheng
Journal Article
Genetics analysis of haptoglobin gene in Fujian Han nationality
ZOU Qilian, LIN Ying, LIN Xiangquan, CHEN Yuanzhong
Journal Article
Revealing High-Efficiency Natural Mycotoxin Antidotes in Zebrafish Model Screening Against Zearalenone-Induced Toxicity
Hong-Yun Zhang,Wei-Dan Jiang,Pei Wu,Yang Liu,Hong-Mei Ren,Xiao-Wan Jin,Xiao-Qiu Zhou,Lin Feng,
Journal Article
Qiu Quan: Research on High Throughput Phenotype Acquisition Robot (2020-8-18)
17 Oct 2022
Conference Videos
Hospital-Based Phenotypic Features and Treatment Outcomes of Chinese Women with Polycystic Ovary Syndrome: The Effect of Body Mass Index and Geographic Distribution
Jingshu Gao, Hongli Ma, Yu Wang, Xinming Yang, Yijuan Cao, Bei Zhang, Conghui Han, Xiaoke Wu
Journal Article
Gao Jingshu: Clinical Phenotype and Treatment Outcome of Chinese Women with Polycystic Ovary Syndrome
23 Oct 2021
Conference Videos