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Current situation and challenge of registry in China
Yang Zhang,Yuji Feng,Zhi Qu,Yali Qi,Siyan Zhan
Frontiers of Medicine 2014, Volume 8, Issue 3, Pages 294-299 doi: 10.1007/s11684-014-0355-x
Increasing emphasis has been placed on registries for an organized system used in developing clinical research to improve health care. China has sufficient data that can be applied broadly, but the heterogeneity and irregularity of registries limit their applicability. This article aims to describe the status of registries in China and the related challenges. Patient registries for observational studies were retrieved from the International Clinical Trials Registry to quantitatively evaluate the number of comparatively high-quality registries in China. A literature search was also performed to provide support and updates. A total of 64 patient registries were retrieved from ClinicalTrials.gov using disease, product, and health service as criteria. The sample sizes ranged from 15 to 30 400, with only 12 registries marked as completed. This article describes and compares the detailed information in many aspects. The efficient use of registries has already made considerable progress in China; however, registries still require standardization, high-quality transition, and coordinated development.
Keywords: observational study Chinese registry study patient registries
Current challenge and perspective of PGM-free cathode catalysts for PEM fuel cells
Gang WU
Frontiers in Energy 2017, Volume 11, Issue 3, Pages 286-298 doi: 10.1007/s11708-017-0477-3
Keywords: oxygen reduction fuel cells cathode nonprecious metal catalysts carbon nanocomposites
The Progress and Grand Challenge of Urbanization in China Views & Comments
Xu Kuangdi
Engineering 2016, Volume 2, Issue 1, Pages 26-28 doi: 10.1016/J.ENG.2016.01.029
An old issue and a new challenge for nuclear reactor safety
F. D’AURIA
Frontiers in Energy 2021, Volume 15, Issue 4, Pages 854-859 doi: 10.1007/s11708-021-0729-0
Keywords: large break loss of coolant accident (LBLOCA) nuclear reactor safety (NRS) licensing perspectives basis for design of water cooled nuclear reactors (WCNR)
David A. Wyrick,Warren Myers
Frontiers of Engineering Management 2016, Volume 3, Issue 3, Pages 203-205 doi: 10.15302/J-FEM-2016046
Keywords: Grand Challenges urban infrastructure development engineering management system of systems strategic management engineering management case study
Pengming SUN PhD, MD , Jalid SEHOULI PhD, MD , Lihui WEI BM ,
Frontiers of Medicine 2009, Volume 3, Issue 3, Pages 256-264 doi: 10.1007/s11684-009-0052-3
Keywords: target therapy gynecologic malignant tumors clinical trail molecular medicine
Coronavirus Variants—Will New mRNA Vaccines Meet the Challenge?
Jennifer Welsh
Engineering 2021, Volume 7, Issue 6, Pages 712-714 doi: 10.1016/j.eng.2021.04.005
Tissue regeneration: dream, hope and challenge
Ding Xiaobing
Strategic Study of CAE 2009, Volume 11, Issue 10, Pages 122-128
Tissue regeneration is the research focus in the fields of biology and medicine in 21 century. In this paper, some very important aspects dealing with the tissue repair and regeneration were reviewed, including its brief history, key scientific points and the advance in some very important fields. Also, our perspective about its development in the future was given.
Keywords: injury tissue repair regeneration
Battery Recycling Challenge Looms as Electric Vehicle Business Booms
Sean O’Neill
Engineering 2021, Volume 7, Issue 12, Pages 1657-1660 doi: 10.1016/j.eng.2021.11.009
Aerodynamic challenges in span length of suspension bridges
XIANG Haifan, GE Yaojun
Frontiers of Structural and Civil Engineering 2007, Volume 1, Issue 2, Pages 153-162 doi: 10.1007/s11709-007-0016-0
Keywords: requirement reasonable limitation challenge particular economical construction
The Challenge of Computing and Information Technology in the 21st Century
Wm. A. Wulf
Strategic Study of CAE 2000, Volume 2, Issue 10, Pages 9-12
Immunological effects of nano-enabled hyperthermia for solid tumors: opportunity and challenge
Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 3, Pages 333-344 doi: 10.1007/s11705-021-2059-5
Keywords: nano-enabled hyperthermia immunogenic cell death heterogeneous immunological landscape tumor microenvironment
Advancements of oil and gas exploration in China offshore area: overview and perspective
Zhu Weilin
Strategic Study of CAE 2010, Volume 12, Issue 5, Pages 18-24
Under the guidance of seeking for large and middle scale oil and gas fields in recent years, the oil and gas exploration in china offshore areas is grounding on regional study and scientific and reasonable deployment as complementation. Considering the unique and complex geological conditions of china offshore area, the innovations of geological understanding and exploration technology are all emphasized, to keep exploration with high efficiency. Great successes have been achieved on the basis of this paradigm, and the newly discovered reserves make historical breakthroughs continuously, suggesting the golden time of the present china offshore oil and gas exploration. However, with the enhancement of exploration extent and enlargement of exploration area, the oil and gas exploration in China offshore area will face more and more challenges.
Keywords: China offshore area large and middle scale oil and gas field high efficiency exploration challenge
Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 4, Pages 512-524 doi: 10.15302/J-FASE -2021393
Settlement patterns and social structures have been shaped by access to water since the onset of human societies. This review covers historical and recent examples from Cambodia, Central Asia, India, Latin America and the Arabian Peninsula to analyze the role of water resources in determining the rise and collapse of civilizations. Over recent decades increasing globalization and concomitant possibilities to externalize water needs as virtual water have obscured global dependence on water resources via telecoupling, but rapid urbanization brings it now back to the political agenda. It is foremost in the urban arena of poorer countries where competing claims for water increasingly lead to scale-transcendent conflicts about ecosystem services. Solutions to the dilemma will require broad stakeholder-based agreements on water use taking into account the available data on water resources, their current and potential use efficiency, recycling of water after effective treatment, and social-ecological approaches of improved governance and conflict resolution.
Keywords: agroecology historical water use water footprint water governance urbanization
Artificial Intelligence Cracks a 50-Year-Old Grand Challenge in Biology
Sean O´Neill
Engineering 2021, Volume 7, Issue 6, Pages 706-708 doi: 10.1016/j.eng.2021.04.003
Title Author Date Type Operation
Current situation and challenge of registry in China
Yang Zhang,Yuji Feng,Zhi Qu,Yali Qi,Siyan Zhan
Journal Article
Current challenge and perspective of PGM-free cathode catalysts for PEM fuel cells
Gang WU
Journal Article
Strategic Project Management to Use the Grand Challenge Scholars Program to Address Urban Infrastructure
David A. Wyrick,Warren Myers
Journal Article
Molecular targeted therapy of gynecological malignant tumors: the development and challenge, from laboratory
Pengming SUN PhD, MD , Jalid SEHOULI PhD, MD , Lihui WEI BM ,
Journal Article
The Challenge of Computing and Information Technology in the 21st Century
Wm. A. Wulf
Journal Article
Immunological effects of nano-enabled hyperthermia for solid tumors: opportunity and challenge
Journal Article
Advancements of oil and gas exploration in China offshore area: overview and perspective
Zhu Weilin
Journal Article
WATER USE IN HUMAN CIVILIZATIONS: AN INTERDISCIPLINARY ANALYSIS OF A PERPETUAL SOCIAL-ECOLOGICAL CHALLENGE
Journal Article