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γδ T cells in liver diseases

Xuefu Wang, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 262-268 doi: 10.1007/s11684-017-0584-x

Abstract: γδ T cells are enriched in the liver and exhibit liver-specific features.fatty liver disease, autoimmune hepatitis, liver fibrosis and cirrhosis, and liver cancer and regenerationWe believe that determining the properties and functions of γδ T cells in liver diseasesenhances our understanding of the pathogenesis of liver diseases and is useful for the design of novelγδ T cell-based therapeutic regimens for liver diseases.

Keywords： γδT cells     liver infection     non-alcoholic fatty liver disease     autoimmune hepatitis     liver fibrosis and cirrhosis     liver cancer     liver regeneration    

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Pyogenic liver abscess as initial presentation in locally advanced right colon cancer invading the liver

Kai Qu, Chang Liu, Aasef M A Mansoor, Bo Wang, Jincai Chen, Liang Yu, Yi Lv

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 434-437 doi: 10.1007/s11684-011-0157-3

Abstract: Locally advanced colorectal cancer complicated with adjacent organic invasion may remain confined toIn the present paper, we report on a patient with advanced right colon cancer, including liver, gallbladder, and duodenal invasion behind the scene of liver abscess.Common clinical manifestations of colorectal cancer were digestive symptoms and changes in defecationHowever, the clinical manifestation of locally advanced colon cancer was extremely complicated.

Keywords： liver abscess     locally advanced colon cancer     multiorganic invasion    

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Role of Intrahepatic Regional Immunity in Post-Transplant Cancer Recurrence Review

Jiang Liu,Chung Mau Lo,Kwan Man

Engineering 2022, Volume 10, Issue 3,   Pages 57-64 doi: 10.1016/j.eng.2021.11.012

Abstract:

Hepatic malignancy is a major indication for liver transplantation; however, post-transplant cancer, and post-transplant immunosuppression regimens have been elucidated as risk factors for recurrent livercancer.cell invasiveness and metastasis after liver transplantation.recurrence after liver transplantation.

Keywords： Liver transplantation     Liver cancer     Recurrence     Immunology    

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Tumor growth and metastasis can be inhibited by maintaining genomic stability in cancer cells

Yi Liang,Qisheng Feng,Jian Hong,Futuo Feng,Yi Sang,Wenrong Hu,Miao Xu,Roujun Peng,Tiebang Kang,Jinxin Bei,Yixin Zeng

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 57-62 doi: 10.1007/s11684-015-0389-8

Abstract:

The existence of cancer stem cells, stem-like cancer cells (SLCCs), or tumor-initiating cells is consideredOur previous research demonstrates that SLCCs are inducible by increasing genomic instability in cancer

Keywords： rabbit VX2 liver tumor     mitomycin C     AET     stem-like cancer cells     genomic instability    

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Partial liver transplantation

Nianqiao GONG, Xiaoping CHEN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 1-7 doi: 10.1007/s11684-010-0105-7

Abstract:

Partial liver transplantation, including reduced-size liver transplantation, split liver transplantation, and living donor liver transplantation, has been developed with several innovative techniques becauseSplit liver transplantation provides chances to two or even more recipients when only one liver graftBefore surgery, a series of donor evaluations—including anatomical, liver volume, and liver functionAt different recipient conditions, auxiliary liver transplantation and auxiliary partial orthotopic liver

Keywords： partial liver transplantation     reduced-size liver transplantation     split liver transplantation     living donorliver transplantation    

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Epigenetic dysregulation in hepatocellular carcinoma: focus on polycomb group proteins

Sandy Leung-Kuen Au, Irene Oi-Lin Ng, Chun-Ming Wong

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 231-241 doi: 10.1007/s11684-013-0253-7

Abstract: modifications of histone, which profoundly affect expression of a wide repertoire of genes critical for cancer

Keywords： liver cancer     epigenetics     histone modifications     polycomb group proteins     enhancer of zeste homolog 2 (EZH2    

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Neutron capture therapy clinical development in the world

Zhang Zichu,Jin Congjun,Liu Kai,Zhang Guozhen,Yang Lijun

Strategic Study of Chinese Academy of Engineering 2012, Volume 14, Issue 8,   Pages 100-105

Abstract: treatment situation and evaluation in glioblastoma (GBM), malignant melanoma, recurrent head and neck cancerand metastatic liver cancer were discussed in detail.

Keywords： BNCT     GBM     malignant melanoma     recurent head & neck cancer     metastatic liver cancer    

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NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 249-261 doi: 10.1007/s11684-018-0622-3

Abstract: innate-like and tissue-resident lymphocytes, which recognize lipid antigens and are enriched in the livernatural killer T cells and their roles in hepatitis B virus and hepatitis C virus infection, autoimmune liverdiseases, alcoholic liver disease, nonalcoholic fatty liver disease, and hepatocellular carcinoma.and indicate the dynamic alteration in the role of natural killer T cells during the progression of liver

Keywords： natural killer T cells     hepatitis B virus and hepatitis C virus infection     autoimmune liver diseases     alcoholicliver disease     nonalcoholic fatty liver disease     hepatocellular carcinoma    

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TCGA whole-transcriptome sequencing data reveals significantly dysregulated genes and signaling pathways in hepatocellular carcinoma

Daniel Wai-Hung Ho,Alan Ka-Lun Kai,Irene Oi-Lin Ng

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 322-330 doi: 10.1007/s11684-015-0408-9

Abstract: by comparing the global gene expression profiles between tumors and their corresponding non-tumorous liver

Keywords： TCGA     whole-transcriptome sequencing     HCC     liver cancer    

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Assessment of liver volume variation to evaluate liver function

Cong Tong, Xinsen Xu, Chang Liu, Tianzheng Zhang, Kai Qu

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 421-427 doi: 10.1007/s11684-012-0223-5

Abstract:

In order to assess the value of liver volumetry in cirrhosis and acute liver failure (ALF) patientsto get a regression formula for standard liver volume (SLV) and BSA.It turned out that the mean liver volume of the control group was 1 058±337 cm3.Child A, B level was not reduced, but in Child C level it was significantly reduced with the lowest liverIn conclusion, the CTLV/SLV ratio, which reflects liver volume variations, correlates well with the liver

Keywords： liver volume variation     cirrhosis     acute liver failure (ALF)    

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Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 269-279 doi: 10.1007/s11684-018-0621-4

Abstract:

The liver has been characterized as a frontline lymphoid organ with complex immunological featuressuch as liver immunity and liver tolerance.Liver tolerance plays an important role in liver diseases including acute inflammation, chronic infectionThe liver contains a large proportion of natural killer (NK) cells, which exhibit heterogeneity in phenotypicUnder the setting of liver diseases, NK cells are of great importance for stimulating or inhibiting immune

Keywords： natural killer cell     phenotype     immune activation     immune tolerance     liver diseases    

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The “Traditional Chinese medicine regulating liver regeneration” treatment plan for reducing mortalityof patients with hepatitis B-related liver failure based on real-world clinical data

Ling Dai, Xiang Gao, Zhihua Ye, Hanmin Li, Xin Yao, Dingbo Lu, Na Wu

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 495-505 doi: 10.1007/s11684-020-0790-9

Abstract: explore the effect and mechanisms of the treatment plan of “traditional Chinese medicine (TCM) regulating liverA total of 457 patients with HBV-related liver failure were retrospectively collected.In addition, there were significant differences in the expression of several cytokines related to liverRLR treatment can decrease jaundice, improve liver function, and significantly reduce the mortality inpatients with HBV-related liver failure.

Keywords： hepatitis B virus-related liver failure     traditional Chinese medicine     liver regeneration     liver regeneration    

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Molecular mechanisms of fatty liver in obesity

Lixia Gan,Wei Xiang,Bin Xie,Liqing Yu

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 275-287 doi: 10.1007/s11684-015-0410-2

Abstract:

Nonalcoholic fatty liver disease (NAFLD) covers a spectrum of liver disorders ranging from simplesteatosis, which is characterized by excessive accumulation of triglyceride-rich lipid droplets in the liverAccumulating evidence supports that dysregulation of adipose lipolysis and liver de novo&

Keywords： nonalcoholic fatty liver disease     insulin resistance     obesity    

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Bioartificial liver devices: Perspectives on the state of the art

Yi-Tao DING, MM, Xiao-Lei SHI, MD

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 15-19 doi: 10.1007/s11684-010-0110-x

Abstract:

Acute liver failure remains a significant cause of morbidity and mortality.Bioartificial liver (BAL) devices have been in development for more than 20 years.Such devices aim to temporarily take over the metabolic and excretory functions of the liver until thepatients’ own liver has recovered or a donor liver becomes available for transplant.failure, and may also be a bridge to liver transplantation.

Keywords： acute liver failure     bioartificial livers     hepatocyte     bioreactor    

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Overview on acute-on-chronic liver failure

Jing Zhang,Shan Gao,Zhongping Duan,Ke-Qin Hu

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 1-17 doi: 10.1007/s11684-016-0439-x

Abstract:

Liver failure (LF) is defined as severe dysfunction in hepatic synthesis, detoxification, and metabolism

Keywords： liver failure     chronic liver failure     acute-on-chronic liver failure     diagnosis     prognosis     treatment    

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Title Author Date Type Operation

γδ T cells in liver diseases

Xuefu Wang, Zhigang Tian

Journal Article

Pyogenic liver abscess as initial presentation in locally advanced right colon cancer invading the liver

Kai Qu, Chang Liu, Aasef M A Mansoor, Bo Wang, Jincai Chen, Liang Yu, Yi Lv

Journal Article

Role of Intrahepatic Regional Immunity in Post-Transplant Cancer Recurrence

Jiang Liu,Chung Mau Lo,Kwan Man

Journal Article

Tumor growth and metastasis can be inhibited by maintaining genomic stability in cancer cells

Yi Liang,Qisheng Feng,Jian Hong,Futuo Feng,Yi Sang,Wenrong Hu,Miao Xu,Roujun Peng,Tiebang Kang,Jinxin Bei,Yixin Zeng

Journal Article

Partial liver transplantation

Nianqiao GONG, Xiaoping CHEN

Journal Article

Epigenetic dysregulation in hepatocellular carcinoma: focus on polycomb group proteins

Sandy Leung-Kuen Au, Irene Oi-Lin Ng, Chun-Ming Wong

Journal Article

Neutron capture therapy clinical development in the world

Zhang Zichu,Jin Congjun,Liu Kai,Zhang Guozhen,Yang Lijun

Journal Article

NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Journal Article

TCGA whole-transcriptome sequencing data reveals significantly dysregulated genes and signaling pathways in hepatocellular carcinoma

Daniel Wai-Hung Ho,Alan Ka-Lun Kai,Irene Oi-Lin Ng

Journal Article

Assessment of liver volume variation to evaluate liver function

Cong Tong, Xinsen Xu, Chang Liu, Tianzheng Zhang, Kai Qu

Journal Article

Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Journal Article

The “Traditional Chinese medicine regulating liver regeneration” treatment plan for reducing mortalityof patients with hepatitis B-related liver failure based on real-world clinical data

Ling Dai, Xiang Gao, Zhihua Ye, Hanmin Li, Xin Yao, Dingbo Lu, Na Wu

Journal Article

Molecular mechanisms of fatty liver in obesity

Lixia Gan,Wei Xiang,Bin Xie,Liqing Yu

Journal Article

Bioartificial liver devices: Perspectives on the state of the art

Yi-Tao DING, MM, Xiao-Lei SHI, MD

Journal Article

Overview on acute-on-chronic liver failure

Jing Zhang,Shan Gao,Zhongping Duan,Ke-Qin Hu

Journal Article