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Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 551-573 doi: 10.1007/s11684-022-0928-z

Abstract: Patients with hepatocellular carcinoma (HCC) and bone metastasis (BM) suffer from greatly reduced lifeHowever, BM in HCC has long been overlooked possibly due to its relatively low prevalence in previousdate, no consensus or guidelines have been reached or formulated for the prevention and management of HCCThe risk factors, diagnosis, prognosis, and therapeutic approaches of HCC BM are detailed to provideWe also present the advances in the pathological and molecular mechanisms of HCC BM to shed light on

Keywords： HCC     bone     osteotropism     clinical     basic researches     advances    

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The impact of hypoxia in hepatocellular carcinoma metastasis

Carmen Chak-Lui Wong, Alan Ka-Lun Kai, Irene Oi-Lin Ng

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 33-41 doi: 10.1007/s11684-013-0301-3

Abstract:

Hypoxia is a common phenomenon in hepatocellular carcinoma (HCC).Expression of HIF is closely associated with metastasis and poor prognosis in HCC.Because HIF is the central regulator of HCC metastasis, HIF inhibitors are attractive tools when usedalone or as combined treatment to curb HCC metastasis.This review will summarize the current findings on the impact of hypoxia/HIF in HCC, with a particular

Keywords： hypoxia     hepatocellular carcinoma (HCC)     metastasis     hypoxia-inducible factor (HIF)    

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Cyclooxygenase-2 gene-1195G/A genotype is associated with the risk of HBV-induced HCC: A case-control

Li-Feng LIU MD, PhD, Qiong CHEN MD, PhD, Ying CHANG MD, PhD, Ju-Sheng LIN MD, PhD, Jin-Liang ZHANG MM,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 90-95 doi: 10.1007/s11684-010-0021-x

Abstract: cyclooxygenase-2 gene promoter and evaluate their effects on the risk of primary hepatocellular carcinoma (HCCSubjects included primary HCC patients with HBV infection (=210), chronic hepatitis B cases (=210) andWe found-1195A allele carriers had a higher risk of HCC with HBV infection (OR, 0.72; 95% CI, 0.548–The-1195A allele might be used as a marker in screening individuals at high risk of HCC with HBV infection

Keywords： cyclooxygenase-2 gene     single nucleotide polymorphisms     susceptibility     primary hepatocellular carcinoma     hepatitis B virus infection    

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Immune response triggered by the ablation of hepatocellular carcinoma with nanosecond pulsed electric field

Jianpeng Liu, Xinhua Chen, Shusen Zheng

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 170-177 doi: 10.1007/s11684-020-0747-z

Abstract: animal experiments show that nsPEF can induce the immunogenic cell death of hepatocellular carcinoma (HCCclinical importance because the nonthermal ablation may enhance the immune memory, which can prevent HCCinhibits the regulatory responses, thereby improving immune stimulation and limiting immunosuppression in HCC-bearingTherefore, nsPEF has excellent potential for HCC treatment.

Keywords： nanosecond pulsed electric fields (nsPEF)     hepatocellular carcinoma (HCC)     immune response     recurrence     metastasis    

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TCGA whole-transcriptome sequencing data reveals significantly dysregulated genes and signaling pathways in hepatocellular carcinoma

Daniel Wai-Hung Ho,Alan Ka-Lun Kai,Irene Oi-Lin Ng

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 322-330 doi: 10.1007/s11684-015-0408-9

Abstract: systematically evaluates the TCGA whole-transcriptome sequencing data of hepatocellular carcinoma (HCC

Keywords： TCGA     whole-transcriptome sequencing     HCC     liver cancer    

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Towards the optimization of management of hepatocellular carcinoma

Xi Feng, Madhava Pai, Malkhaz Mizandari, Tinatin Chikovani, Duncan Spalding, Long Jiao, Nagy Habib

Frontiers of Medicine 2011, Volume 5, Issue 3,   Pages 271-276 doi: 10.1007/s11684-011-0148-4

Abstract: Hepatocellular carcinoma (HCC) is the fifth most common neoplasm in the world, closely correlated withThe vast majority of HCC patients present at a late stage and are unsuitable for surgery due to limitedA series of new technologies have been developed to optimise HCC management.

Keywords： management     hepatocellular carcinoma (HCC)     radiofrequency (RF) ablation     laparoscopic liver resection     stem    

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Association of miRNA-122-binding site polymorphism at the interleukin-1 α gene and its interaction with hepatitis B virus mutations with hepatocellular carcinoma risk

Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 217-226 doi: 10.1007/s11684-014-0326-2

Abstract: HBV surface antigen (HBsAg) seroclearance subjects, and 2011 HBsAg-positive subjects (including 1021 HCCperformed to test the associations of rs3783553, mutations, and their interactions with the risk of HCCNo significant association was found between rs3783553 and the risk of HCC among healthy controls, HBsAgseroclearance subjects, HBsAg-positive subjects without HCC, and all controls.Multiplicative interaction of rs3783553 with HBV preS deletion significantly reduced the risk of HCC

Keywords： hepatocellular carcinoma (HCC)     interaction     miRNA-122-binding site     IL-1A     rs3783553     hepatitis B virus (    

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Post-surgical resection prognostic value of combined OPN, MMP7, and PSG9 plasma biomarkers in hepatocellular carcinoma

Weiqi Rong, Yang Zhang, Lei Yang, Lin Feng, Baojun Wei, Fan Wu, Liming Wang, Yanning Gao, Shujun Cheng, Jianxiong Wu, Ting Xiao

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 250-258 doi: 10.1007/s11684-018-0632-1

Abstract: Biomarkers for hepatocellular carcinoma (HCC) following curative resection are not currently sufficient), matrix metalloproteinase 7 (MMP7), and pregnancy specific glycoprotein 9 (PSG9) in patients with HCCA total of 179 prospective patients with HCC provided plasma before hepatectomy.OPN was demonstrated to be a risk factor-associated OS in stage I patients with HCC and patients with, particularly in the early stage of HCC carcinogenesis.

Keywords： biomarkers     OPN     MMP7     PSG9     HCC     prognosis    

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Title Author Date Type Operation

Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives

Journal Article

The impact of hypoxia in hepatocellular carcinoma metastasis

Carmen Chak-Lui Wong, Alan Ka-Lun Kai, Irene Oi-Lin Ng

Journal Article

Cyclooxygenase-2 gene-1195G/A genotype is associated with the risk of HBV-induced HCC: A case-control

Li-Feng LIU MD, PhD, Qiong CHEN MD, PhD, Ying CHANG MD, PhD, Ju-Sheng LIN MD, PhD, Jin-Liang ZHANG MM,

Journal Article

Immune response triggered by the ablation of hepatocellular carcinoma with nanosecond pulsed electric field

Jianpeng Liu, Xinhua Chen, Shusen Zheng

Journal Article

TCGA whole-transcriptome sequencing data reveals significantly dysregulated genes and signaling pathways in hepatocellular carcinoma

Daniel Wai-Hung Ho,Alan Ka-Lun Kai,Irene Oi-Lin Ng

Journal Article

Towards the optimization of management of hepatocellular carcinoma

Xi Feng, Madhava Pai, Malkhaz Mizandari, Tinatin Chikovani, Duncan Spalding, Long Jiao, Nagy Habib

Journal Article

Association of miRNA-122-binding site polymorphism at the interleukin-1 α gene and its interaction with hepatitis B virus mutations with hepatocellular carcinoma risk

Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen

Journal Article

Post-surgical resection prognostic value of combined OPN, MMP7, and PSG9 plasma biomarkers in hepatocellular carcinoma

Weiqi Rong, Yang Zhang, Lei Yang, Lin Feng, Baojun Wei, Fan Wu, Liming Wang, Yanning Gao, Shujun Cheng, Jianxiong Wu, Ting Xiao

Journal Article