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Post-surgical resection prognostic value of combined OPN, MMP7, and PSG9 plasma biomarkers in hepatocellular

Weiqi Rong, Yang Zhang, Lei Yang, Lin Feng, Baojun Wei, Fan Wu, Liming Wang, Yanning Gao, Shujun Cheng, Jianxiong Wu, Ting Xiao

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 250-258 doi: 10.1007/s11684-018-0632-1

Abstract: (PSG9) in patients with HCC.Plasma OPN, MMP7, and PSG9 levels were determined by enzyme-linked immunosorbent assay.High OPN (≥149.97 ng/mL), MMP7 (≥2.28 ng/mL), and PSG9 (≥45.59 ng/mL) were prognostic indicators of reducedPlasma PSG9 protein level was an independent factor in predicting OS ( =0.008) and DFS ( =0.038).These findings suggested that OPN, MMP7, PSG9 and their combined panels may be useful for aiding in tumor

Keywords： biomarkers     OPN     MMP7     PSG9     HCC     prognosis    

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Acetylated HOXB9 at lysine 27 is of differential diagnostic value in patients with pancreatic ductal

Xiaoran Sun, Jiagui Song, Jing Zhang, Jun Zhan, Weigang Fang, Hongquan Zhang

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 91-100 doi: 10.1007/s11684-019-0696-6

Abstract: AcK27-HOXB9 is a newly identified HOXB9 post-transcriptional modification that can predict the outcomeHOXB9 was upregulated ( <0.0001), and AcK27-HOXB9 ( =0.0023) was downregulated in patients with PDAC.HOXB9 promoted ( =0.0115), while AcK27-HOXB9 ( =0.0279) inhibited PDAC progression.The results of this study showed that HOXB9 promoted and AcK27-HOXB9 suppressed PDAC progression.The determination of ratio between HOXB9 and AcK27-HOXB9 exhibited potential diagnostic value in patients

Keywords： HOXB9     AcK27-HOXB9     PDAC    

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662 A/G gene variation in human tumor necrosis factor receptor superfamily, member 9 (TNFRSF9)

QU Yanchun, YANG Ze, SUN Liang, JI Linong

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 283-285 doi: 10.1007/s11684-008-0053-7

Abstract: The aim of this paper is to report a new coding variance of the gene, a candidate for autoimmune diseases. We found the variation in two families with type 2 diabetes mellitus by D-HPLC mutation screening method and confirmed our results by direct sequencing and PCR-RFLP. Although without changing the amino acid coding, the variance may have an effect on codon usage and play a role in disease development, such as type 2 diabetes mellitus. However, we cannot define the role of this variance because the frequency of the minor allele is low in the Chinese population and no homozygote of the variance was found. More research in multiple populations will be necessary to define the role of this variance.

Keywords： D-HPLC mutation     development     autoimmune     PCR-RFLP     candidate    

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Mobile CRISPR-Cas9 based anti-phage system in E. coli

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 8,   Pages 1281-1289 doi: 10.1007/s11705-022-2141-7

Abstract: Here, we developed a mobile CRISPR-Cas9 based anti-phage system for bacteriophages defense in E. coli

Keywords： phage infections     anti-phage     CRISPR-Cas9     conjugative transfer     synthetic biology    

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The 9th China Engineering Management Forum Guangzhou Consensus

Frontiers of Engineering Management 2015, Volume 2, Issue 2,   Pages 105-107 doi: 10.15302/J-FEM-2015019

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CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells

Yongping Zhang, Xingying Zhang, Chen Cheng, Wei Mu, Xiaojuan Liu, Na Li, Xiaofei Wei, Xiang Liu, Changqing Xia, Haoyi Wang

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 554-562 doi: 10.1007/s11684-017-0543-6

Abstract: successfully generated LAG-3 knockout T and CAR-T cells with high efficiency using CRISPR-Cas9

Keywords： CAR-T     CRISPR-Cas9     LAG-3    

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Construction of lentiviral vector carrying Rab9 gene and its expression in mouse brain

Youguo HAO, Min ZHANG, Jinzhi XU, Bitao BU, Jiajun WEI

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 141-147 doi: 10.1007/s11684-009-0041-6

Abstract: Rab9 mediates late endosome-to- -Golgi-network trafficking.encoding Rab9.DNA sequencing proved the successful construction of pCDH1-MCF1-Rab9-EF1-copGFP.It is concluded that the packaging of Lentivirus encoding Rab9 was successful.Lentivirus encoding Rab9 can increase the expression of Rab9 gene effectively, which might offer a novel

Keywords： Rab9     lentivirus     gene therapy     gene transfer    

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REDUCTION OF NON-POINT SOURCE POLLUTION IN THE YONG’AN RIVER BY CONSTRUCTED WETLAND BASED ON 9 YEARS

Frontiers of Agricultural Science and Engineering 2023, Volume 10, Issue 4,   Pages 627-638 doi: 10.15302/J-FASE-2023516

Abstract: This paper reports 9 years of monitoring the Yong’an River and its surrounding constructed wetlands

Keywords： inflowing rivers     surface-flow constructed wetland     nutrients     long-term monitoring    

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Compiling of comprehensive data of human infections with novel influenza A (H7N9) virus

Ying Wu, George F. Gao

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 275-276 doi: 10.1007/s11684-013-0285-z

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Research progress on human infection with avian influenza H7N9

Xiaoxin Wu, Lanlan Xiao, Lanjuan Li

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 8-20 doi: 10.1007/s11684-020-0739-z

Abstract: Since the first case of novel H7N9 infection was reported, China has experienced five epidemics of H7N9During the fifth wave, a highly pathogenic H7N9 strain emerged.Meanwhile, the H7N9 virus continues to accumulate mutations, and its affinity for the human respiratorycharacteristics of H7N9, the key gene mutations of the virus, and H7N9 vaccine, thus providing a scientificbasis for further monitoring and prevention of H7N9 influenza epidemics.

Keywords： H7N9     pandemic     epidemiology     mutations     vaccine     influenza    

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Adenosine deaminase 2 regulates the activation of the Toll-like receptor 9 in response to nucleic acids

Frontiers of Medicine doi: 10.1007/s11684-024-1067-5

Abstract: Adenosine deaminase 2 regulates the activation of the Toll-like receptor 9 in response to nucleic acids

Keywords： response nucleic acids    

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Frequency domain a9ctive vibration control of a flexible plate based on neural networks

Jinxin LIU, Xuefeng CHEN, Zhengjia HE

Frontiers of Mechanical Engineering 2013, Volume 8, Issue 2,   Pages 109-117 doi: 10.1007/s11465-013-0252-z

Abstract:

A neural-network (NN)-based active control system was proposed to reduce the low frequency noise radiation of the simply supported flexible plate. Feedback control system was built, in which neural network controller (NNC) and neural network identifier (NNI) were applied. Multi-frequency control in frequency domain was achieved by simulation through the NN-based control systems. A pre-testing experiment of the control system on a real simply supported plate was conducted. The NN-based control algorithm was shown to perform effectively. These works lay a solid foundation for the active vibration control of mechanical structures.

Keywords： active vibration control (AVC)     neural network (NN)     low frequency noise     frequency domain control     multi-frequency control    

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Research of the Preparation Technology for Zr66Al9Cu16Ni9

Ruan Xuping,Ruan Hongwei

Strategic Study of CAE 2004, Volume 6, Issue 5,   Pages 76-78

Abstract: some elements in the melt, therefore, it wasn´t favourable for coating the Zr66Al9Ni9Cu16 alloy, hence hindering the formation of the amorphous state.reacted with some elements in the melt, so they were not suitable for purifying the Zr66Al9Ni9Cu16 alloy.

Keywords： bulk amorphous alloy     preparation technology     glass     fused salt     vacuum degree    

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The first avian influenza A (H7N9) viral infection in humans in Zhejiang Province, China: a death report

Enfu Chen, Fenjuan Wang, Huakun Lv, Yanjun Zhang, Hua Ding, Shelan Liu, Jian Cai, Li Xie, Xiaoping Xu, Chengliang Chai, Haiyan Mao, Jimin Sun, Junfen Lin, Zhao Yu, Lianhong Li, Zhiping Chen, Shichang Xia

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 333-344 doi: 10.1007/s11684-013-0275-1

Abstract:

This study reports the first death caused by a novel avian influenza A (H7N9) virus in Zhejiang ProvinceThis H7N9 virus from Zhejiang is highly similar to isolates obtained from Shanghai, Jiangsu, Anhui, etchealth workers presented with influenza-like symptoms, and they subsequently tested negative for H7N9possible high-risk factors for infections and death caused by the low-pathogenicity avian influenza A (H7N9)Person-to-person transmission of the H7N9 virus was not detected among close contacts, but such transmission

Keywords： avian influenza A (H7N9) virus     epidemiology     contacts     person-to-person transmission    

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Lymphatic metastasis is related to the epithelial-mesenchymal transition and expressions of VEGF, MMP-9,

Lihui WANG, Lianhong LI, Shen LV, Shujun FAN, Li ZHAN, Bo WANG, Zhong ZHANG

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 164-170 doi: 10.1007/s11684-009-0038-1

Abstract: E-Cad), N-cadherin (N-Cad), vascular endothelial cell growth factor (VEGF), matrix metalloproteinase-9(MMP-9), cyclooxygenase-2 (COX-2), and CD34 were examined in 74 cases of breast cancer, including 39The expressions of N-Cad, VEGF, MMP-9, and COX-2 in cases with lymph node metastasis were significantlyThis study indicates that EMT and expressions of VEGF, MMP-9 and COX-2, and MVD value are strongly correlated

Keywords： epithelial-mesenchymal transition     vascular endothelial cell growth factor     matrix metalloproteinase-9    

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Title Author Date Type Operation

Post-surgical resection prognostic value of combined OPN, MMP7, and PSG9 plasma biomarkers in hepatocellular

Weiqi Rong, Yang Zhang, Lei Yang, Lin Feng, Baojun Wei, Fan Wu, Liming Wang, Yanning Gao, Shujun Cheng, Jianxiong Wu, Ting Xiao

Journal Article

Acetylated HOXB9 at lysine 27 is of differential diagnostic value in patients with pancreatic ductal

Xiaoran Sun, Jiagui Song, Jing Zhang, Jun Zhan, Weigang Fang, Hongquan Zhang

Journal Article

662 A/G gene variation in human tumor necrosis factor receptor superfamily, member 9 (TNFRSF9)

QU Yanchun, YANG Ze, SUN Liang, JI Linong

Journal Article

Mobile CRISPR-Cas9 based anti-phage system in E. coli

Journal Article

The 9th China Engineering Management Forum Guangzhou Consensus

Journal Article

CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells

Yongping Zhang, Xingying Zhang, Chen Cheng, Wei Mu, Xiaojuan Liu, Na Li, Xiaofei Wei, Xiang Liu, Changqing Xia, Haoyi Wang

Journal Article

Construction of lentiviral vector carrying Rab9 gene and its expression in mouse brain

Youguo HAO, Min ZHANG, Jinzhi XU, Bitao BU, Jiajun WEI

Journal Article

REDUCTION OF NON-POINT SOURCE POLLUTION IN THE YONG’AN RIVER BY CONSTRUCTED WETLAND BASED ON 9 YEARS

Journal Article

Compiling of comprehensive data of human infections with novel influenza A (H7N9) virus

Ying Wu, George F. Gao

Journal Article

Research progress on human infection with avian influenza H7N9

Xiaoxin Wu, Lanlan Xiao, Lanjuan Li

Journal Article

Adenosine deaminase 2 regulates the activation of the Toll-like receptor 9 in response to nucleic acids

Journal Article

Frequency domain a9ctive vibration control of a flexible plate based on neural networks

Jinxin LIU, Xuefeng CHEN, Zhengjia HE

Journal Article

Research of the Preparation Technology for Zr66Al9Cu16Ni9

Ruan Xuping,Ruan Hongwei

Journal Article

The first avian influenza A (H7N9) viral infection in humans in Zhejiang Province, China: a death report

Enfu Chen, Fenjuan Wang, Huakun Lv, Yanjun Zhang, Hua Ding, Shelan Liu, Jian Cai, Li Xie, Xiaoping Xu, Chengliang Chai, Haiyan Mao, Jimin Sun, Junfen Lin, Zhao Yu, Lianhong Li, Zhiping Chen, Shichang Xia

Journal Article

Lymphatic metastasis is related to the epithelial-mesenchymal transition and expressions of VEGF, MMP-9,

Lihui WANG, Lianhong LI, Shen LV, Shujun FAN, Li ZHAN, Bo WANG, Zhong ZHANG

Journal Article