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RR2 gene deletion affects the immunogenicity of a live attenuated pseudorabies virus vaccine candidate

Shijun YAN,He YAN,Chaolin ZHANG,Tongyan WANG,Qingyuan YANG,Zhe SUN,Yan XIAO,Feifei TAN,Xiangdong LI,Kegong TIAN

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 1,   Pages 81-86 doi: 10.15302/J-FASE-2016088

Abstract: based on a / / triple gene-deleted pseudorabies virus and tested its efficacy in pigs as a vaccine candidate

Keywords： pseudorabies virus     RR1 and RR2     ribonucleotide reductase     vaccine candidate    

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immune mapped protein 1 (NcIMP1) is a novel vaccine candidate against neosporosis

Xia CUI,Daoyu YANG,Tao LEI,Hui WANG,Pan HAO,Qun LIU

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1,   Pages 66-72 doi: 10.15302/J-FASE-2015047

Abstract: identified as a membrane protein, and a previous study indicated that NcIMP1 could be a promising vaccine candidateThese data suggest that IMP1 is a promising vaccine candidate against neosporosis.

Keywords： Neospora caninum     immune mapped protein 1 (IMP1)     vaccine candidate     BALB/c mice    

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Corrosion mechanisms of candidate structural materials for supercritical water-cooled reactor

Lefu ZHANG, Fawen ZHU, Rui TANG

Frontiers in Energy 2009, Volume 3, Issue 2,   Pages 233-240 doi: 10.1007/s11708-009-0024-y

Abstract: martensitic heat-resistant steels, and oxide dispersion strengthened steel are presently considered to be the candidateHowever, corrosion and stress corrosion cracking of these candidate alloys still remain to be a majorSurvey of literature and experimental results reveal that the general corrosion mechanism of those candidateThis paper focuses on the mechanism of corrosion oxide film breakdown for SCWR candidate materials.

Keywords： supercritical water-cooled reactor     general corrosion     oxide film     corrosion mechanism    

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Human monoclonal antibodies as candidate therapeutics against emerging viruses

Yujia Jin, Cheng Lei, Dan Hu, Dimiter S. Dimitrov, Tianlei Ying

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 462-470 doi: 10.1007/s11684-017-0596-6

Abstract:

The emergence of new pathogens, such as severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and Ebola virus, poses serious challenges to global public health and highlights the urgent need for novel antiviral approaches. Monoclonal antibodies (mAbs) have been successfully used to treat various diseases, particularly cancer and immunological disorders. Antigen-specific mAbs have been isolated using several different approaches, including hybridoma, transgenic mice, phage display, yeast display, and single B-cell isolation. Consequently, an increasing number of mAbs, which exhibit high potency against emerging viruses in vitro and in animal models of infection, have been developed. In this paper, we summarize historical trends and recent developments in mAb discovery, compare the advantages and disadvantages of various approaches to mAb production, and discuss the potential use of such strategies for the development of antivirals against emerging diseases. We also review the application of recently developed human mAbs against SARS-CoV, MERS-CoV, and Ebola virus and discuss prospects for the development of mAbs as therapeutic agents against emerging viral diseases.

Keywords： human monoclonal antibodies     emerging infectious diseases     SARS-CoV     MERS-CoV     Ebola virus    

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Mutation profiling of 16 candidate genes in

Yang Zhang, Fang Wang, Xue Chen, Wenjing Liu, Jiancheng Fang, Mingyu Wang, Wen Teng, Panxiang Cao, Hongxing Liu

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 229-237 doi: 10.1007/s11684-018-0616-1

Abstract: Mutation profiling of 16 candidate genes were performed in bone marrow samples by using Sanger sequencing

Keywords： leukemia     myeloid     acute     gene     mutation    

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Genome-wide association analysis reveals genetic loci and candidate genes associated with intramuscular

Xingwang WANG, Rongrong DING, Jianping QUAN, Linxue YANG, Ming YANG, Enqin ZHENG, Dewu LIU, Gengyuan CAI, Zhenfang WU, Jie YANG

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 335-341 doi: 10.15302/J-FASE-2017152

Abstract: study were to identify or refine the positions of genomic regions affecting IMF, and to characterize candidateThree genes proximal to these significant SNPs were considered candidate genes, including , and .

Keywords： Duroc pigs     genome-wide association analysis     intramuscular fat    

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systematic survey of LU domain-containing proteins reveals a novel human gene, LY6A, which encodes the candidate

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 458-475 doi: 10.1007/s11684-022-0968-4

Abstract: human LU domain-containing proteins, we identified a previously unannotated human gene encoding the candidateCollectively, these studies unveil a novel human gene encoding a candidate biomarker and provide an interesting

Keywords： LU domain-containing protein family     novel human gene     LY6A     pituitary tumor     biomarker     nonsynonymous SNP     GPI-anchored protein    

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PtHAK5, a candidate for mediating high-affinity K

Haili YANG, Weidan ZHANG, Weiwei CHAI, Wenying WANG, Li GAO, Jing ZHANG, Yongping WANG, Suo-Min WANG

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 1,   Pages 108-117 doi: 10.15302/J-FASE-2018200

Abstract: In conclusion, PtHAK5 is a candidate for mediating high-affinity K uptake under low K conditions.

Keywords： K+ uptake     PtHAK5     Puccinellia tenuiflora     yeast complementation    

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Genome-wide search for candidate genes determining vertebrae number in pigs

Longchao ZHANG, Jingwei YUE, Xin LIU, Jing LIANG, Kebin ZHAO, Hua YAN, Na LI, Lei PU, Yuebo ZHANG, Huibi SHI, Ligang WANG, Lixian WANG

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 327-334 doi: 10.15302/J-FASE-2017163

Abstract: was the closest gene to the most significant SNP and might be a candidate.Haplotype sharing and block analysis refined the QTL to an interval of about 3 Mb containing 29 candidatethese genes via additional genetic and functional studies in mammals revealed that could be a good candidateA mutation of c.1749G>A was detected by GWAS and could be proposed as a candidate causal mutation,

Keywords： genome-wide association study     number of vertebrae     pig     SSC7     TGFβ3    

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662 A/G gene variation in human tumor necrosis factor receptor superfamily, member 9 (TNFRSF9)

QU Yanchun, YANG Ze, SUN Liang, JI Linong

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 283-285 doi: 10.1007/s11684-008-0053-7

Abstract: The aim of this paper is to report a new coding variance of the gene, a candidate for autoimmune diseases

Keywords： D-HPLC mutation     development     autoimmune     PCR-RFLP     candidate    

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WC coatings as candidate to hard chrome plating: characterization of fatigue and friction and wear

Zhou Kesong,Deng Chunming,Liu Min

Strategic Study of CAE 2009, Volume 11, Issue 10,   Pages 48-54

Abstract:

Fatigue and friction and wear performances against Al—Ni—Bronze alloy for bare and coated 300 M steel were investigated with the application of WC coating into landing gear as background in this paper. The results indicated that both WC-17Co and WC-10Co4Cr coated 300 M steel exhibited comparable fatigue limit and cycles to fatigue failure with those of bare 300 M steel; while the fatigue limit and cycles to fatigue failure of 300 M steel were decreased by 120 MPa and 70 %~90 % respectively when 300 M steel was plated with chrome plating. The effect of coating on the fatigue property of 300 M steel was attributed to the propagation of fatigue crack in coating. Fatigue crack in WC coating deflected along the interface between WC coating and 300 M steel; while fatigue crack in chrome plating propagated into 300 M steel, provided as a sub-crack initiator and hastened the propagation of main fatigue crack in 300 M steel and finally led to the decrease of cycles to fatigue failure of 300 M steel. Friction and wear behaviors of coatings against Al—Ni—Bronze alloy lubricated by 10# aircraft hydraulic oil revealed that great volume loss was observed for Al—Ni—Bronze alloy and obvious mass gain was found for chrome plated 300 M steel when chrome plating was against Al—Ni—Bronze alloy; slight volume loss was obtained for WC coating, and the volume loss of Al—Ni—Bronze alloy against WC coating was only 1/50~1/100 of Al—Ni—Bronze alloy against chrome plating at all the three loads. The wear mechanism for WC coating and chrome plating against Al—Ni—Bronze alloy was respectively governed by abrasive wear and adhesive wear.

Keywords： 300 M steel     high velocity air fuel     WC coating     chrome plating     fatigue     friction and wear    

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Study on Family Collection, Gene Mapping, Gene Identification and Gene Function of Human Genetic Diseases

Xia Jiahui

Strategic Study of CAE 2000, Volume 2, Issue 11,   Pages 1-11

Abstract: human genetic neurological deafness gene, was identified using a novel strategy of “Gene Family-Candidate

Keywords： genetic disease     gene mapping and cloning     gene familiy-candidate disease gene cloning     genome wide scan    

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Intelligent computing budget allocation for on-road trajectory planning based on candidate curves Article

Xiao-xin FU,Yong-heng JIANG,De-xian HUANG,Jing-chun WANG,Kai-sheng HUANG

Frontiers of Information Technology & Electronic Engineering 2016, Volume 17, Issue 6,   Pages 553-565 doi: 10.1631/FITEE.1500269

Abstract: trajectory planning is solved by introducing intelligent computing budget allocation (ICBA) into a candidate-curve-basedThe best trajectory curve is picked from a set of candidate curves, where each curve is evaluated bybudget allocation framework presented in this paper can also be used to enhance the efficiency of other candidate-curve-based

Keywords： Intelligent computing budget allocation     Trajectory planning     On-road planning     Intelligent vehicles     Ordinal optimization    

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Title Author Date Type Operation

RR2 gene deletion affects the immunogenicity of a live attenuated pseudorabies virus vaccine candidate

Shijun YAN,He YAN,Chaolin ZHANG,Tongyan WANG,Qingyuan YANG,Zhe SUN,Yan XIAO,Feifei TAN,Xiangdong LI,Kegong TIAN

Journal Article

immune mapped protein 1 (NcIMP1) is a novel vaccine candidate against neosporosis

Xia CUI,Daoyu YANG,Tao LEI,Hui WANG,Pan HAO,Qun LIU

Journal Article

Corrosion mechanisms of candidate structural materials for supercritical water-cooled reactor

Lefu ZHANG, Fawen ZHU, Rui TANG

Journal Article

Human monoclonal antibodies as candidate therapeutics against emerging viruses

Yujia Jin, Cheng Lei, Dan Hu, Dimiter S. Dimitrov, Tianlei Ying

Journal Article

Mutation profiling of 16 candidate genes in

Yang Zhang, Fang Wang, Xue Chen, Wenjing Liu, Jiancheng Fang, Mingyu Wang, Wen Teng, Panxiang Cao, Hongxing Liu

Journal Article

Genome-wide association analysis reveals genetic loci and candidate genes associated with intramuscular

Xingwang WANG, Rongrong DING, Jianping QUAN, Linxue YANG, Ming YANG, Enqin ZHENG, Dewu LIU, Gengyuan CAI, Zhenfang WU, Jie YANG

Journal Article

systematic survey of LU domain-containing proteins reveals a novel human gene, LY6A, which encodes the candidate

Journal Article

PtHAK5, a candidate for mediating high-affinity K

Haili YANG, Weidan ZHANG, Weiwei CHAI, Wenying WANG, Li GAO, Jing ZHANG, Yongping WANG, Suo-Min WANG

Journal Article

Genome-wide search for candidate genes determining vertebrae number in pigs

Longchao ZHANG, Jingwei YUE, Xin LIU, Jing LIANG, Kebin ZHAO, Hua YAN, Na LI, Lei PU, Yuebo ZHANG, Huibi SHI, Ligang WANG, Lixian WANG

Journal Article

662 A/G gene variation in human tumor necrosis factor receptor superfamily, member 9 (TNFRSF9)

QU Yanchun, YANG Ze, SUN Liang, JI Linong

Journal Article

WC coatings as candidate to hard chrome plating: characterization of fatigue and friction and wear

Zhou Kesong,Deng Chunming,Liu Min

Journal Article

Study on Family Collection, Gene Mapping, Gene Identification and Gene Function of Human Genetic Diseases

Xia Jiahui

Journal Article

Intelligent computing budget allocation for on-road trajectory planning based on candidate curves

Xiao-xin FU,Yong-heng JIANG,De-xian HUANG,Jing-chun WANG,Kai-sheng HUANG

Journal Article