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The critical importance of epigenetics in autoimmune-related skin diseases
Frontiers of Medicine 2023, Volume 17, Issue 1, Pages 43-57 doi: 10.1007/s11684-022-0980-8
Keywords: epigenetics autoimmune-related skin diseases DNA methylation histone modifications noncoding RNAs
Farhad Sahebjam,John M. Vierling
Frontiers of Medicine 2015, Volume 9, Issue 2, Pages 187-219 doi: 10.1007/s11684-015-0386-y
Autoimmune hepatitis is a chronic liver disease putatively caused by loss of tolerance to hepatocyte-specificAlthough autoimmune hepatitis occurs in childhood, this review focuses on disease in adults.Transplant recipients are at risk for recurrent autoimmune hepatitis in the allograft, and de
Keywords: autoimmune hepatitis autoantibodies diagnosis immunological diseases drug-induced liver injury therapy
Frontiers of Medicine 2023, Volume 17, Issue 3, Pages 534-548 doi: 10.1007/s11684-022-0953-y
Keywords: autoimmune hepatitis (AIH) concanavalin A (Con A) human menstrual blood-derived stem cells (MenSCs)
Th17 Cells in autoimmune diseases
Lei Han,Jing Yang,Xiuwen Wang,Dan Li,Ling Lv,Bin Li
Frontiers of Medicine 2015, Volume 9, Issue 1, Pages 10-19 doi: 10.1007/s11684-015-0388-9
Keywords: IL-17 Th17 cells RORγt autoimmune diseases posttranslational modification inhibitors
Diagnostic criteria of latent autoimmune diabetes in adults (LADA): a review and reflection
Yu Liao, Yufei Xiang, Zhiguang Zhou
Frontiers of Medicine 2012, Volume 6, Issue 3, Pages 243-247 doi: 10.1007/s11684-012-0201-y
Keywords: LADA diagnostic criteria autoantibodies insulin independence age of diagnosis
Autoimmune regulator regulates autophagy in THP-1 human monocytes
Liang SHI, Li-Hua HU, Yi-Rong LI
Frontiers of Medicine 2010, Volume 4, Issue 3, Pages 336-341 doi: 10.1007/s11684-010-0096-4
Keywords: autoimmune regulator autophagy monocytes light chain 3 (LC3)
Xuefu Wang, Zhigang Tian
Frontiers of Medicine 2018, Volume 12, Issue 3, Pages 262-268 doi: 10.1007/s11684-017-0584-x
Keywords: γδT cells liver infection non-alcoholic fatty liver disease autoimmune hepatitis liver fibrosis and cirrhosis
Pathogenesis, diagnosis, and treatment of recurrent spontaneous abortion with immune type
Qi-De LIN, Li-Hua QIU
Frontiers of Medicine 2010, Volume 4, Issue 3, Pages 275-279 doi: 10.1007/s11684-010-0101-y
Keywords: spontaneous abortion recurrent autoimmune alloimmune pathogenesis diagnosis immunotherapy
Shasha Zhu, Huimin Zhang, Li Bai
Frontiers of Medicine 2018, Volume 12, Issue 3, Pages 249-261 doi: 10.1007/s11684-018-0622-3
Keywords: natural killer T cells hepatitis B virus and hepatitis C virus infection autoimmune liver diseases alcoholic
662 A/G gene variation in human tumor necrosis factor receptor superfamily, member 9 (TNFRSF9)
QU Yanchun, YANG Ze, SUN Liang, JI Linong
Frontiers of Medicine 2008, Volume 2, Issue 3, Pages 283-285 doi: 10.1007/s11684-008-0053-7
Keywords: D-HPLC mutation development autoimmune PCR-RFLP candidate
Recent advances in myeloid-derived suppressor cell biology
Mahmoud Mohammad Yaseen, Nizar Mohammad Abuharfeil, Homa Darmani, Ammar Daoud
Frontiers of Medicine 2021, Volume 15, Issue 2, Pages 232-251 doi: 10.1007/s11684-020-0797-2
Keywords: non-human primates (rhesus macaques) myeloid-derived pro-inflammatory cells (MDPCs) autoimmune disorders
Ting Li, Tongtong Pan, Nannan Zheng, Xiong Ma, Xiaodong Wang, Fang Yan, Huimian Jiang, Yuxin Wang, Hongwei Lin, Jing Lin, Huadong Zhang, Jia Huang, Lingming Kong, Anmin Huang, Qingxiu Liu, Yongping Chen, Dazhi Chen
Engineering 2024, Volume 36, Issue 5, Pages 209-222 doi: 10.1016/j.eng.2024.01.006
One-third of patients with autoimmune hepatitis (AIH) have cirrhosis at the time of diagnosis.
Keywords: Autoimmune hepatitis Polymeric immunoglobulin receptor Regenerating islet-derived 3 beta Intestinal microbiota
FOXP3 and Its Cofactors as Targets of Immunotherapies Review
Yasuhiro Nagai,Lian Lam,Mark I. Greene,Hongtao Zhang
Engineering 2019, Volume 5, Issue 1, Pages 115-121 doi: 10.1016/j.eng.2019.01.001
Forkhead box P3 (FOXP3) is a "master regulator" of regulatory T cells (Tregs), which are a subset of T cells that can suppress the antigen-specific immune reaction and that play important roles in host tolerance and immune homeostasis. It is well known that FOXP3 forms complexes with several proteins and can be regulated by various post-translational modifications (PTMs) such as acetylation, phosphorylation, ubiquitination, and methylation. As a consequence, the PTMs change the stability of FOXP3 and its capability to regulate gene expression, and eventually affect Treg activity. Although FOXP3 per se is not an ideal drug target, deacetylases, acetyltransferases, kinases, and other enzymes that regulate the PTMs of FOXP3 are potential targets to modulate FOXP3 and Treg activity. However, FOXP3 is not the only substrate for most of these enzymes; thus, unwanted "on target/off FOXP3" side effects must be considered when inhibitors to these enzymes are used. In this review, we summarize recent progress in the study of FOXP3 cofactors and PTM proteins, and potential clinical applications in autoimmunity and cancer immunity.
Keywords: Treg Forkhead box P3 (FOXP3) Post-translational modification Autoimmune Cancer
Sun Jia: Target Intestinal Flora to Regulate Autoimmune Response(2020.1.10)
孙嘉(高级职称)
23 Jun 2020
Keywords: 营养健康
Title Author Date Type Operation
Human menstrual blood-derived stem cells alleviate autoimmune hepatitis via JNK/MAPK signaling pathway
Journal Article
Th17 Cells in autoimmune diseases
Lei Han,Jing Yang,Xiuwen Wang,Dan Li,Ling Lv,Bin Li
Journal Article
Diagnostic criteria of latent autoimmune diabetes in adults (LADA): a review and reflection
Yu Liao, Yufei Xiang, Zhiguang Zhou
Journal Article
Autoimmune regulator regulates autophagy in THP-1 human monocytes
Liang SHI, Li-Hua HU, Yi-Rong LI
Journal Article
Pathogenesis, diagnosis, and treatment of recurrent spontaneous abortion with immune type
Qi-De LIN, Li-Hua QIU
Journal Article
662 A/G gene variation in human tumor necrosis factor receptor superfamily, member 9 (TNFRSF9)
QU Yanchun, YANG Ze, SUN Liang, JI Linong
Journal Article
Recent advances in myeloid-derived suppressor cell biology
Mahmoud Mohammad Yaseen, Nizar Mohammad Abuharfeil, Homa Darmani, Ammar Daoud
Journal Article
Effects of Polymeric Immunoglobulin Receptor in Regulating Interleukin-17 Signaling and Preventing Autoimmune
Ting Li, Tongtong Pan, Nannan Zheng, Xiong Ma, Xiaodong Wang, Fang Yan, Huimian Jiang, Yuxin Wang, Hongwei Lin, Jing Lin, Huadong Zhang, Jia Huang, Lingming Kong, Anmin Huang, Qingxiu Liu, Yongping Chen, Dazhi Chen
Journal Article
FOXP3 and Its Cofactors as Targets of Immunotherapies
Yasuhiro Nagai,Lian Lam,Mark I. Greene,Hongtao Zhang
Journal Article
Sun Jia: Target Intestinal Flora to Regulate Autoimmune Response(2020.1.10)
孙嘉(高级职称)
23 Jun 2020
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