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Frontiers of Medicine 2024, Volume 18, Issue 2, Pages 327-343 doi: 10.1007/s11684-023-1022-x
Keywords: promyelocytic leukemia plasma proteomics plasma metabolomics cross-sectional correlation network pathogenesis
Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment
Tianhua Xu, Zitong Sheng, Li Yao
Frontiers of Medicine 2017, Volume 11, Issue 3, Pages 340-348 doi: 10.1007/s11684-017-0570-3
In light of the rapid increase in the number of obesity incidences worldwide, obesity has become an independent risk factor for chronic kidney disease. Obesity-related glomerulopathy (ORG) is characterized by glomerulomegaly in the presence or absence of focal and segmental glomerulosclerosis lesions. IgM and complement 3 (C3) nonspecifically deposit in lesions without immune-complex-type deposits during ORG immunofluorescence. ORG-associated glomerulomegaly and focal and segmental glomerulosclerosis can superimpose on other renal pathologies. The mechanisms under ORG are complex, especially hemodynamic changes, inflammation, oxidative stress, apoptosis, and reduced functioning nephrons. These mechanisms synergize with obesity to induce end-stage renal disease. A slow increase of subnephrotic proteinuria (<3.5 g/d) is the most common clinical manifestation of ORG. Several treatment methods for ORG have been developed. Of these methods, renin–angiotensin–aldosterone system blockade and weight loss are proven effective. Targeting mitochondria may offer a novel strategy for ORG therapy. Nevertheless, more research is needed to further understand ORG.
Keywords: obesity-related glomerulopathy pathogenesis pathologic clinical characteristics
Various brain-eating amoebae: the protozoa, the pathogenesis, and the disease
Frontiers of Medicine 2021, Volume 15, Issue 6, Pages 842-866 doi: 10.1007/s11684-021-0865-2
Keywords: free-living amoebae central nervous system infection primary amoebic meningoencephalitis granulomatous amoebic encephalitis
Epidemiology, pathogenesis, and management of coronavirus disease 2019-associated stroke
Frontiers of Medicine 2023, Volume 17, Issue 6, Pages 1047-1067 doi: 10.1007/s11684-023-1041-7
Keywords: SARS-CoV-2 ischemic stroke stroke hemorrhagic stroke cerebral venous thrombosis vaccination
MicroRNAs and lung cancers: from pathogenesis to clinical implications
Ji Qi, David Mu
Frontiers of Medicine 2012, Volume 6, Issue 2, Pages 134-155 doi: 10.1007/s11684-012-0188-4
Keywords: lung biology lung cancer microRNA
Guangbiao Zhou, Saijuan Chen, Zhu Chen
Frontiers of Medicine 2020, Volume 14, Issue 2, Pages 117-125 doi: 10.1007/s11684-020-0773-x
Keywords: COVID-19 SARS-CoV-2 pathogenesis evidence-based medicine control and therapeutic strategies
Molecular pathogenesis of acute myeloid leukemia: A diverse disease with new perspectives
Felicitas THOL, Arnold GANSER
Frontiers of Medicine 2010, Volume 4, Issue 4, Pages 356-362 doi: 10.1007/s11684-010-0220-5
Keywords: acute myeloid leukemia mutations risk stratification
Pathogenesis, diagnosis, and treatment of recurrent spontaneous abortion with immune type
Qi-De LIN, Li-Hua QIU
Frontiers of Medicine 2010, Volume 4, Issue 3, Pages 275-279 doi: 10.1007/s11684-010-0101-y
Keywords: spontaneous abortion recurrent autoimmune alloimmune pathogenesis diagnosis immunotherapy
Joseph Cannova,Peter Breslin S.J.,Jiwang Zhang
Frontiers of Medicine 2015, Volume 9, Issue 3, Pages 288-303 doi: 10.1007/s11684-015-0412-0
Keywords: TLR MyD88 hematopoiesis bone marrow failure leukemia myelodysplastic syndrome
AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches
Megan A. Hatlen, Lan Wang, Stephen D. Nimer
Frontiers of Medicine 2012, Volume 6, Issue 3, Pages 248-262 doi: 10.1007/s11684-012-0206-6
The AML1-ETO fusion transcription factor is generated by the t(8;21) translocation, which is present in approximately 4%–12% of adult and 12%–30% of pediatric acute myeloid leukemia (AML) patients. Both human and mouse models of AML have demonstrated that AML1-ETO is insufficient for leukemogenesis in the absence of secondary events. In this review, we discuss the pathogenetic insights that have been gained from identifying the various events that can cooperate with AML1-ETO to induce AML in vivo. We also discuss potential therapeutic strategies for t(8;21) positive AML that involve targeting the fusion protein itself, the proteins that bind to it, or the genes that it regulates. Recently published studies suggest that a targeted therapy for t(8;21) positive AML is feasible and may be coming sometime soon.
Keywords: AML1-ETO mouse model leukemia t(8 21) pathway hits mutation hematopoiesis Kasumi-1 CD34+
Frontiers of Medicine 2024, Volume 18, Issue 2, Pages 285-302 doi: 10.1007/s11684-023-1035-5
Keywords: amyotrophic lateral sclerosis N6-methyladenosine epi-transcriptome proteome single cell RNA sequencing analysis CX3CR1
Frontiers of Medicine 2022, Volume 16, Issue 5, Pages 723-735 doi: 10.1007/s11684-021-0905-y
Keywords: amyotrophic lateral sclerosis coronin-1a autophagy pathogenesis
Review of hand, foot and mouth disease
Lan-Juan LI MD,
Frontiers of Medicine 2010, Volume 4, Issue 2, Pages 139-146 doi: 10.1007/s11684-010-0033-6
Keywords: hand foot and mouth disease epidemiology pathogenesis management surveillance
Reconsideration of endometriosis and its clinical significance
Lang Jinghe
Strategic Study of CAE 2009, Volume 11, Issue 10, Pages 137-142
Keywords: Endometriosis pathogenesis diagnosis treatment
Pathogenesis of pandemic H1N1 2009 influenza virus infection and the implication on management
Kelvin Kai-Wang TO FRCPath, Iris Wai-Sum LI FRCP, Ivan Fan-Ngai HUNG FRCP, Vincent Chi-Chung CHENG FRCPath, Kwok-Yung YUEN MD,
Frontiers of Medicine 2010, Volume 4, Issue 2, Pages 147-156 doi: 10.1007/s11684-010-0030-9
Keywords: influenza A virus H1N1 subtype pandemic pathogenesis virulence factors immunity management antiviral
Title Author Date Type Operation
Cross-sectional network analysis of plasma proteins/metabolites correlated with pathogenesis and therapeutic
Journal Article
Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment
Tianhua Xu, Zitong Sheng, Li Yao
Journal Article
Epidemiology, pathogenesis, and management of coronavirus disease 2019-associated stroke
Journal Article
MicroRNAs and lung cancers: from pathogenesis to clinical implications
Ji Qi, David Mu
Journal Article
Advances in COVID-19: the virus, the pathogenesis, and evidence-based control and therapeutic strategies
Guangbiao Zhou, Saijuan Chen, Zhu Chen
Journal Article
Molecular pathogenesis of acute myeloid leukemia: A diverse disease with new perspectives
Felicitas THOL, Arnold GANSER
Journal Article
Pathogenesis, diagnosis, and treatment of recurrent spontaneous abortion with immune type
Qi-De LIN, Li-Hua QIU
Journal Article
Toll-like receptor signaling in hematopoietic homeostasis and the pathogenesis of hematologic diseases
Joseph Cannova,Peter Breslin S.J.,Jiwang Zhang
Journal Article
AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches
Megan A. Hatlen, Lan Wang, Stephen D. Nimer
Journal Article
Dysregulated N-methyladenosine modification in peripheral immune cells contributes to the pathogenesis
Journal Article
Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker and therapeutic target
Journal Article