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Homoharringtonine synergy with oridonin in treatment of t(8; 21) acute myeloid leukemia

Weina Zhang, Ying Lu, Tao Zhen, Xinjie Chen, Ming Zhang, Ping Liu, Xiangqin Weng, Bing Chen, Yueying Wang

Frontiers of Medicine 2019, Volume 13, Issue 3, Pages 388-397 doi: 10.1007/s11684-018-0624-1

Abstract: Collaboration of c-KIT mutations with AML1–ETO (AE) has been demonstrated to induce t(8; 21) acute myeloidTherefore, studies should explore the efficacy of combination therapy with oridonin and HHT in t(8; 21The combination of oridonin and HHT prolonged t(8; 21) leukemia mouse survival.In conclusion, oridonin and HHT exert synergistic effects against t(8; 21) leukemia and , therebyindicating that their combination may be an effective therapy for t(8; 21) leukemia.

Keywords： AML1–ETO c-KIT homoharringtonine oridonin t(8 21) AML synergistic effect

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Innate and adaptive T cells in influenza disease

Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska

Frontiers of Medicine 2018, Volume 12, Issue 1, Pages 34-47 doi: 10.1007/s11684-017-0606-8

Abstract: Moreover, vaccines designed to generate influenza-specific T-cell responses are yet to be optimized.Adaptive T and B cells maintain immunological memory and provide protection against subsequent infectionsRecent studies also shed light on the role of innate T-cells (MAIT cells, gd T cells, and NKT cells)We summarize the current knowledge on influenza-specific innate MAIT and gd T cells as well as adaptiveCD8⁺ and CD4⁺ T cells, and discuss how these responses can be harnessed by novel

Keywords： influenza innate T cells CD4⁺ and CD8⁺ T cells vaccination

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sup>CD117^dim/CD34⁺CD117^bri myeloblast-associated gene expression in t(8;21) acute myeloid leukemia

Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang

Frontiers of Medicine 2021, Volume 15, Issue 4, Pages 608-620 doi: 10.1007/s11684-021-0836-7

Abstract: t(8;21)(q22;q22) acute myeloid leukemia (AML) is a highly heterogeneous hematological malignancy withTwo leukemic myeloblast populations (CD34 CD117 and CD34 CD117 ) were previously identified in t(8;21Here, we examined the impact of CD34 CD117 /CD34 CD117 myeloblast-associated gene expression on t(8;In this study, 85 patients with t(8;21) AML were enrolled.8;21) AML.

Keywords： t(8 21)(q22 q22) AML CD34⁺CD117^dim/ CD34⁺CD117^bri cell population

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MoS₂/ZIF-8 Hybrid Materials for Environmental Catalysis: Solar-Driven Antibiotic-Degradation Article

Wen-Qian Chen, Linyue Li, Lin Li, Wen-Hui Qiu, Liang Tang, Ling Xu, Kejun Xu, Ming-Hong Wu

Engineering 2019, Volume 5, Issue 4, Pages 755-767 doi: 10.1016/j.eng.2019.02.003

Abstract: In this paper, we demonstrate a MoS₂/ZIF-8 composite photocatalyst that increases the photocatalyticThe hydrogen production rate of the MoS₂/ZIF-8 nanocomposites is 1.79 times higher than thatThis work provides a novel perspective for exploring original and efficient 1T/2H-MoS₂/MOF-basedThus, 1T/2H-MoS₂/MOF-based photocatalysts have excellent prospects for practical antibiotic-degradation

Keywords： 1T/2H-MoS₂ ZIF-8 Antibiotic degradation Photocatalysis

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A rare case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) translocation

Xiaofeng Shi, Rong Ba, Haiyan You, Qian Jiang, Jiansong Huang, Jianhua Mao, Lanxiu Han, Shuo Zhang, Qin Zhuang, Xianqiu Yu, Lixia Wang, Yun Wang, Dongya Li, Wei Zhu, Yong Zhang, Yan Zhu, Xiaodong Xi

Frontiers of Medicine 2018, Volume 12, Issue 3, Pages 324-329 doi: 10.1007/s11684-017-0558-z

Abstract: At present, only one case of SLVL with t(8;14)(q24;q32) translocation has been reported.In this study, we report a case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) chromosome translocation that we inclined to SLVL with a prolymphocytic transformationThe karyotype showed complex abnormality: 46XX,+3,−10, t(8;14)(q24;q32)[11]/46XX[⁹].8,14) chromosome translocation.

Keywords： splenic lymphoma with villous lymphocytes splenic marginal zone lymphoma transformation chromosome translocation

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Zeolitic imidazolate framework-8 (ZIF-8) for drug delivery: A critical review

Simin Feng, Xiaoli Zhang, Dunyun Shi, Zheng Wang

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 2, Pages 221-237 doi: 10.1007/s11705-020-1927-8

Abstract: Zeolitic imidazolate framework-8 (ZIF-8), composed of Zn ions and imidazolate ligands, is a class ofaspects ranging from synthesis methods, property characterization to potential applications of ZIF-8.This review focuses on the recent development of ZIF-8 synthesis methods and its promising applicationsThe potential risks of using ZIF-8 for drug delivery are also summarized.

Keywords： zeolitic imidazolate framework-8 (ZIF-8) synthesis methods applications drug delivery

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Role of salivary matrix metalloproteinase-8 (MMP-8) in chronic periodontitis diagnosis

Namita Gupta,N.D. Gupta,Akash Gupta,Saif Khan,Neha Bansal

Frontiers of Medicine 2015, Volume 9, Issue 1, Pages 72-76 doi: 10.1007/s11684-014-0347-x

Abstract: This study aimed to correlate salivary levels of MMP-8 and periodontal parameters of chronic periodontitisto establish MMP-8 as a noninvasive marker for the early diagnosis of chronic periodontitis.Around 3 ml of unstimulated and whole expectorated saliva was collected for MMP-8 estimation by ELISAusing Quantikine human total MMP-8 immunoassay kits.The MMP-8 levels and periodontal status (PPD, CAL, GI, and PI) of groups I and II showed positive and

Keywords： matrix metalloproteinase-8 chronic periodontitis pocket probing depth clinical attachment level gingival

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AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

Megan A. Hatlen, Lan Wang, Stephen D. Nimer

Frontiers of Medicine 2012, Volume 6, Issue 3, Pages 248-262 doi: 10.1007/s11684-012-0206-6

Abstract:

The AML1-ETO fusion transcription factor is generated by the t(8;21) translocation, which is presentWe also discuss potential therapeutic strategies for t(8;21) positive AML that involve targeting theRecently published studies suggest that a targeted therapy for t(8;21) positive AML is feasible and may

Keywords： AML1-ETO mouse model leukemia t(8 21) pathway hits mutation hematopoiesis Kasumi-1 CD34+

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Protective efficacy of vaccination with NcMIC3 and NcMIC8 against

Taotao ZHANG, Xiao ZHANG, Qun LIU, Jianhai XU, Jing LIU

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 2, Pages 188-196 doi: 10.15302/J-FASE-2019253

Abstract: Several studies have indicated that MIC3 and MIC8 are important adhesion factors and potential vaccinestudy, we evaluated the protective efficacy of recombinant proteins and DNA vaccines of NcMIC3 and NcMIC8.BALB/c mice were immunized with rNcMIC3, rNcMIC8, pcDNA3.1-NcMIC3 and pcDNA3.1-NcMIC8 respectively, andIn addition, mice immunized with rNcMIC3 and rNcMIC8 a had lower parasite burden in brain tissue comparedThese results demonstrate that rNcMIC3 and rNcMIC8 could induce humoral and Th2-type immune response,

Keywords： NcMIC3 NcMIC8 Neospora caninum vaccination

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The Undersea Tunnel on Qingdao Metro Line 8

Weiguo He, Peng Liu

Engineering 2018, Volume 4, Issue 2, Pages 167-169 doi: 10.1016/j.eng.2018.03.012

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Development of 8-inch Key Processes for Insulated-Gate Bipolar Transistor Article

Guoyou Liu,Rongjun Ding,Haihui Luo

Engineering 2015, Volume 1, Issue 3, Pages 361-366 doi: 10.15302/J-ENG-2015043

Abstract:

Based on the construction of the 8-inch fabrication line, advanced process technology of 8-inch wafergreat-leap forward technological development for the manufacturing of high-voltage IGBT from 6-inch to 8-

Keywords： insulated-gate bipolar transistor (IGBT) high power density trench gate 8-inch rail transportation

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Prohibitin regulates mTOR pathway via interaction with FKBP8

Jiahui Zhang, Yanan Yin, Jiahui Wang, Jingjing Zhang, Hua Liu, Weiwei Feng, Wen Yang, Bruce Zetter, Yingjie Xu

Frontiers of Medicine 2021, Volume 15, Issue 3, Pages 448-459 doi: 10.1007/s11684-020-0805-6

Abstract: FK506 binding protein 8 (FKBP8) is an intrinsic inhibitor of mTOR kinase that also exerts an anti-apoptoticproteomic analysis that the mitochondrial protein prohibitin 1 (PHB1) specifically interacts with FKBP8.inhibited the proliferation of ovarian cancer cells and the mTOR signaling pathway, whereas the FKBP8Moreover, concomitant with these changes, the interaction between FKBP8 and mTOR substantially increasedCollectively, our finding highlights PHB1 as a potential regulator of FKBP8 because of its subcellular

Keywords： prohibitin 1 FKBP8 mTOR cell proliferation cancer

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Predictive values of plasma TNFα and IL-8 for intracranial hemorrhage in patients with acute promyelocytic

Frontiers of Medicine 2022, Volume 16, Issue 6, Pages 909-918 doi: 10.1007/s11684-021-0890-1

Abstract: Results showed that tumor necrosis factor α and interleukin 8 (IL-8) were vital in distinguishing patientsFinally, in-vitro and in-vivo experimental evidence were provided to show that IL-8 influenced

Keywords： acute promyelocytic leukemia intracranial hemorrhage cytokines biomarker

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Parametric study on the mixed solvent synthesis of ZIF-8 nano- and micro-particles for CO adsorption:

Alireza Hadi, Javad Karimi-Sabet, Abolfazl Dastbaz

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 4, Pages 579-594 doi: 10.1007/s11705-018-1770-3

Abstract: The room temperature synthesis of ZIF-8 micro- and nano-particles was investigated using a mixed methanol-waterZIF-8 particles of good quality and high crystallinity were obtained.Response surface methodology was used to determine the effect of the synthesis conditions on the ZIF-8method to size-controlled synthesis of ZIF-8 particles.adsorption and the mid-sized ZIF-8 particles had the highest adsorption capacity.

Keywords： metal organic frameworks zeolitic imidazolate frameworks ZIF-8 response surface methodology Box Behnken

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IRF4 and IRF8 expression are associated with clinical phenotype and clinico-hematological response to

Frontiers of Medicine 2022, Volume 16, Issue 3, Pages 403-415 doi: 10.1007/s11684-021-0858-1

Abstract: We have previously shown that interferon regulatory factor-8 (IRF8) and IRF4 serve as tumor suppressorsIn this study, we evaluated the expression of IRF4 and IRF8 and the JAK2V617F mutant allele burden inNegative correlations between the JAK2V617F allele burden and the expression of IRF8 (P <0.05)At 3 months, patients in the CR group showed high IRF4 and IRF8 expression compared with patients inOur data indicate that the expression of IRF4 and IRF8 was associated with the MPN phenotype, which may

Keywords： myeloproliferative neoplasms IRF4 IRF8 hydroxyurea essential thrombocythemia

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Title Author Date Type Operation

Homoharringtonine synergy with oridonin in treatment of t(8; 21) acute myeloid leukemia

Weina Zhang, Ying Lu, Tao Zhen, Xinjie Chen, Ming Zhang, Ping Liu, Xiangqin Weng, Bing Chen, Yueying Wang

Journal Article

Innate and adaptive T cells in influenza disease

Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska

Journal Article

sup>CD117^dim/CD34⁺CD117^bri myeloblast-associated gene expression in t(8;21) acute myeloid leukemia

Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang

Journal Article

MoS₂/ZIF-8 Hybrid Materials for Environmental Catalysis: Solar-Driven Antibiotic-Degradation

Wen-Qian Chen, Linyue Li, Lin Li, Wen-Hui Qiu, Liang Tang, Ling Xu, Kejun Xu, Ming-Hong Wu

Journal Article

A rare case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) translocation

Xiaofeng Shi, Rong Ba, Haiyan You, Qian Jiang, Jiansong Huang, Jianhua Mao, Lanxiu Han, Shuo Zhang, Qin Zhuang, Xianqiu Yu, Lixia Wang, Yun Wang, Dongya Li, Wei Zhu, Yong Zhang, Yan Zhu, Xiaodong Xi

Journal Article

Zeolitic imidazolate framework-8 (ZIF-8) for drug delivery: A critical review

Simin Feng, Xiaoli Zhang, Dunyun Shi, Zheng Wang

Journal Article

Role of salivary matrix metalloproteinase-8 (MMP-8) in chronic periodontitis diagnosis

Namita Gupta,N.D. Gupta,Akash Gupta,Saif Khan,Neha Bansal

Journal Article

AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

Megan A. Hatlen, Lan Wang, Stephen D. Nimer

Journal Article

Protective efficacy of vaccination with NcMIC3 and NcMIC8 against

Taotao ZHANG, Xiao ZHANG, Qun LIU, Jianhai XU, Jing LIU