期刊首页 优先出版 当期阅读 过刊浏览 作者中心 关于期刊 English

《中国工程科学》 >> 2023年 第25卷 第5期 doi: 10.15302/J-SSCAE-2023.05.018

生物医药研发数字基础设施体系建设研究

1. 浙江数字医疗卫生技术研究院,杭州 311100;

2. 温州医科大学药学院,浙江温州 325035;

3. 中国科学院基础医学与肿瘤研究所,杭州 310000;

4. 温州医科大学,浙江温州 325035;

5. 浙江大学医学院附属第一医院,杭州 310003

资助项目 :中国工程院咨询项目“生物医药产业人工智能大数据集成平台发展战略研究”(2022-DFZD-28) 收稿日期: 2023-09-13 修回日期: 2023-10-15 发布日期: 2023-10-30

下一篇 上一篇

摘要

生物医药产业正以前所未有的速度发展,其研发数字基础设施体系的建设和完善是国家生物科技创新和健康中国建设的重要基石。本文论述了生物医药研发数字基础设施的内涵与新时期生物医药研发数字基础设施的分类和系统体系;总结了美国、欧盟和我国生物医药研发数字基础设施战略布局的现状及发展路径,梳理了我国生物医药研发数字基础设施建设在国际影响力和权威性、发展模式设计和效能、可持续建设、管理组织架构建设方面与欧美国家存在的差距及在顶层设计、管理治理方面面临的挑战。研究建议,加强生物医药研发数字基础设施顶层设计,加强生物医学和健康医疗资源的统筹编排,加强单一个体平台集群化整合建设和治理,加强开放平台能力建设和运营保障。

图片

图1

图2

参考文献

[ 1 ] Mirowski P‍. The future(s) of open science [J]‍. Social Studies of Science, 2018, 48(2): 171‒203‍.

[ 2 ] Fecher B, Kahn R, Sokolovska N, al et‍. Making a research infrastructure: Conditions and strategies to transform a service into an infrastructure [J]‍. Science and Public Policy, 2021, 48(4): 499‒507‍.

[ 3 ] Zhang L L, Li J H, Paul F, al et‍. Research e-infrastructures for open science: The national example of CSTCloud in China [J]‍.Data Intelligence, 2023, 5 (2): 355‒369‍.

[ 4 ] Zhao Z, Huang J‍.Analysis of information resource construction mode of open science infrastructures [J] ‍.Library Development, 2021, 44(3): 46‒55‍.

[ 5 ] UNESCO‍. Recommendation on open science [EB/OL]‍. (2021-11-26)[2023-08-22]‍. http://www‍.unesco‍.org/en/articles/unesco-sets-ambitious-international-standards-open-science. 链接1

[ 6 ] Hardisty A, Roberts D, The Biodiversity Informatics Community‍. A decadal view of biodiversity informatics: Challenges and priorities [J]‍. BMC Ecology, 2013, 13: 16‍.

[ 7 ] National Academies of Sciences, Engineering and Medicine, Policy and Global Affairs, al et‍. Open science by design: Realizing a vision for 21st century research [M]‍.Washington DC: The National Academies Press, 2018‍.

[ 8 ] 余辉 , 梁镇涛 , 鄢宇晨‍‍ . 多来源多模态数据融合与集成研究进展 [J]‍. 情报理论与实践 , 2020 , 43 11 : 169 ‒ 178 ‍.
Yu H , Liang Z T , Yan Y C‍ . Review on multi-source and multi-modal data fusion and integration [J]‍. Information Studies: Theroy Application , 2020 , 43 11 : 169 ‒ 178 ‍.

[ 9 ] 周小林 , 李力 , 杨云 , 等‍ . 欧盟大型研究基础设施路线图的经验及对中国大科学监测评估的启示 [J]‍. 中国科技论坛 , 2020 1 : 181 ‒ 188 ‍.
Zhou X L , Li L , Yang Y , al e t ‍. Experience in the EU large research infrastructure roadmap and implications for big science monitoring and evaluation in China [J]‍. The China Science and Technology Forum , 2020 1 : 181 ‒ 188 ‍.

[10] Ribes D‍. The kernel of a research infrastructure [C]‍. New York: Association for Computing Machinery, 2014‍.

[11] Ramaprasad A, Valenta A L, Brooks I S, al et‍. Biomedical informatics infrastructure‍ [J]‍. Urban Economics & Regional Studies eJournal, 2007: 1305712‍.

[12] Davidson S M, Heineke J‍.Toward an effective strategy for the diffusion and use of clinical information systems [J]‍. Journal of the American Medical Informatics Association, 2007, 14 (3): 361‒367‍.

[13] Lauer D K B, Smith A, Blomberg D N, al et‍. Open data: A driving force for innovation in the life sciences [EB/OL]‍. (2021-08-19)[2023-08-22]‍. https: //f1000research‍.com/documents/10-828‍. 链接1

[14] U‍.S‍. National Library of Medicine‍. A platform for biomedical discovery and data-powered health strategic plan 2017—2027 [EB/OL]‍. (2018-03-06)[2023-08-22]‍. https: //www‍.nlm‍.nih‍.gov/pubs/plan/lrp17/NLM_StrategicReport2017_2027‍.pdf‍. 链接1

[15] National Institutes of Health‍. NIH-Wide strategic plan for fiscal years 2021—2025 [EB/OL]‍. (2021-07-30)‍[2023-08-22]‍. https: //www‍.nih‍.gov/sites/default/files/about-nih/strategic-plan-fy2021-2025-508‍.pdf‍. 链接1

[16] National Institutes of Health‍.About the STRIDES initiative [EB/OL]‍. (2021-07-30)‍[2022-11-01]‍. https: //datascience‍.nih‍.gov/strides‍. 链接1

[17] 苏燕 , 李伟 , 李祯祺 , 等‍ . 美国生物大数据战略举措及其对我国的启示 [J]‍. 中华医学图书情报杂志 , 2020 , 29 10 : 32 ‒ 37 ‍.
Su Y , Li W , Li Z Q , al e t ‍. Strategic measures taken by USA for biological big data and their enlightenments [J]‍. Chinese Joural of Medical Library and Information Science , 2020 , 29 10 : 32 ‒ 37 ‍.

[18] National Institutes of Health‍. The NIH BRAIN initiative: An overview [EB/OL]‍. (2020-10-05) [2022-11-01]‍. https: //www‍.nimh‍.nih‍.gov/news/events/2020/townhall/the-nih-brain-initiative-an-overview‍. 链接1

[19] Collins F S, Schwetz T A, Tabak L A, al et‍. ARPA-H: Accelerating biomedical breakthroughs [J]‍. Science, 2021, 373(6551): 165‒167‍.

[20] Hillson N, Caddick M, Cai Y, al et‍. Building a global alliance of biofoundries [J]‍. Nature Communication, 2019: 2040‍.

[21] Shaping Europe´s digital future: Commission presents strategies for data and Artificial Intelligence [EB/OL]‍. (2020-02-19)‍[2022-11-01]‍. https: //futurium‍.ec‍.europa‍.eu/sites/default/files/2020-08/Shaping_Europe_s_digital_ future__Commission_presents_strategies_for_data_and_Artificial_Intelligence‍.pdf‍. 链接1

[22] Harrow J, Drysdale R, Smith A, al et‍. ELIXIR: Providing a sustainable infrastructure for life science data at European scale [J]‍.Bioinformatics, 2021, 37(16): 2506‒2511‍.

[23] Uuropean commission CORDISEU research results [EB/OL] ‍. (2021-03-15)[2023-10-12]‍. https: //cordis‍.europa‍.eu/projects/en‍. 链接1

[24] Horizon Europe´s first strategic plan 2021—2024: Commission sets research and innovation priorities for a sustainable future [EB/OL]‍. (2021-03-15)‍[2022-11-01]‍. https: //commission‍.europa‍.eu/system/files/2021-09/ec_rtd_ horizon-europe-strategic-plan-2021-24‍.pdf‍. 链接1

[25] 俞胜杰‍ . 《通用数据保护条例》中的域外管辖问题研究 [D]‍. 上海 : 华东政法大学博士学位论文 , 2020 ‍.
Yu S J‍ . Research on extraterritorial jurisdiction in the General data protection regulations [D]‍. Shanghai : East China University of Political Science and Law Doctoral dissertation , 2020 ‍.

[26] 樊代明‍ . 生物医学大数据是重要战略资源 [J]‍. 科学新闻 , 2019 6 : 34 ‍.
Fan D M‍ . Biomedical big data is an important strategic resource [J]‍. Science News , 2019 6 : 34 ‍.

[27] Zhang L L, Li J H, Uhlir P F, al et‍. Research e-infrastructures for open science: The national example of CSTCloud in China [J]‍.Data Intelligence, 2023, 5(2): 355‒369‍.

[28] Kamdar M R, Ferna´ndez J D, Polleres A, al et‍. Enabling web-scale data integration in biomedicine through linked open data [J]‍.npj Digital Medicine, 2019, 2(1): 1‒14‍.

[29] Laufs D, Peters M, Schultz C‍. Data platforms for open life sciences—A systematic analysis of management instruments [J]‍.PLoS One, 2022, 17(10): e0276204‍.

相关研究