期刊首页 优先出版 当期阅读 过刊浏览 作者中心 关于期刊 English

《中国工程科学》 >> 2004年 第6卷 第8期

自体骨髓干细胞移植研究进展

中国中医研究院西苑医院,北京 100091

收稿日期: 2003-10-10 修回日期: 2004-03-22 发布日期: 2004-08-20

下一篇 上一篇

摘要

细胞移植作为一种新的治疗方法备受医学界关注,但细胞供应短缺和免疫排斥是阻碍这一疗法临床推广的主要难题。自体骨髓干细胞移植在一定程度上可缓解此矛盾。文章综述了自体骨髓干细胞移植治疗脑、肝、心等重要器官疾病的基础和临床研究现状,以及骨髓动员剂在骨髓干细胞移植中的作用。

参考文献

[ 1 ] JiangY , JahagirdarBN , ReinhardtRL , etal.Pluripotencyofmesenchymalstemcellsderivedfromadultmarrow[J].Nature, 2002;418 (6893) :41~49

[ 2 ] BrazeltonTR , RossiFMV , KeshetGI , etal.Frommarrowtobrain:expressionofneuronalphenotypesinadultmice[J].Science, 2000, 290:1775~1779

[ 3 ] MezeyE , ChandrossKJ, HartaG , etal.Turningbloodintobrain:cellsbearingneuronalantigensgeneratedinvivofrombonemarrow[J].Science2000, 290:1779~1782

[ 4 ] MezeyE , KeyS , VogelsangG , etal.tranplantationbonemarrowgeneratesnewneuronsinhumanbrains[J].ProcNatlAcadSciUSA , 2003, 100 (3) :1364~1369

[ 5 ] WeimannJM , CharltonCA , BrazeltonTR , etal.ContributionoftransplantedbonemarrowcellstoPurkinjeneuronsinhumanadultbrains[J].ProcNatlAcadSciUSA , 2003, 100 (4) :2088~2093

[ 6 ] AkiyamaY , RadtkeC , HonmouO , etal.Remyelinationofthespinalcordfollowingintravenousdeliveryofbonemarrowcells[J].Glia, 2002, 39 (3) :229~236

[ 7 ] OrlicD , KajsturaJ, ChimentiS , etal.Bonemarrowcellsregenerateinfractedmyocardium[J].Nature2001, 410:701~705

[ 8 ] 李连达, 张荣利, 冯新庆, 等.双龙方与自体骨髓单个核细胞经心导管移植对中国小型猪心肌梗塞的影响[J].中国新药杂志, 2003, 12 (12) :812~817 链接1

[ 9 ] StrauerBE , BrchmM , ZeusT , etal.Intracoronaryhumanautologousstemcelltransplantationformyocardialregenerationfollowingmyocardialinfarction[J].DtschMedWochenschr, 2001, 126 (3435) :932~938

[10] LiTS , HamanoK , HirataK , etal.Thesafetyandfeasibilityofthelocalimplantationofautologousbonemarrowcellsforischemicheartdisease[J].JCardSurg, 2003;18 (Suppl2) :S69~75

[11] TateishiYuyamaE , MatsubaraH , MuroharaT , etal.Therapeuticangiogenesisfor patientswithlimbischaemiabyautologoustransplantationofbone marrowcells:apilotstudyandarandomisedcontrolledtrial[J].Lancet, 2002, 360 (9331) :427~435

[12] PetersenBE , BowenWC , PatreneKD , etal.Bonemarrowasapotentialsourceofhepaticovalcells[J].Science, 1999, 284 (5417) :1168~1170

[13] AlisonMR , PoulsomR , JefferyR , etal.Hepatocytesfromnonhepaticadultstemcells[J].Nature, 2000, 406:257

[14] TheiseND , NimmakayaluM , GardnerR , etal.Liverfrombonemarrowinhumans[J].Hepatology, 2000, 32 (1) :11~16

[15] LagasseE , ConnorsH , AlDhalimyM , etal.Purifiedhematopoieticstemcellscandifferentiateintohepatocytesinvivo[J].NatMed, 2000, 6 (11) :1229~1234

[16] SchwartzRE , ReyesM , KoodieL , etal.Multipotentadultprogenitorcellsfrombonemarrowdifferentiateintofunctionalhepatocyte likecells[J].JClinInvest, 2002, 109 (10) :1291~1302

[17] WangX , MontiniE , AlDhalimyM , etal.Kineticsofliverrepopulationafterbonemarrowtransplantation[J].AmJPathol.2002, 161 (2) :565~574

[18] 吴理茂, 李连达, 刘 红, 等.自体骨髓干细胞移植与归元方联用治疗急慢性肝损伤的实验研究[J].中国工程科学, 2004, 6 (7) :34~42 链接1

[19] OrlicD , KajsturaJ , ChimentiS , etal.Mobilizedbonemarrowcellsrepairtheinfractedheart, improvingfunctionandsurvival[J].ProcNatlAcadSciUSA , 2001, 98 (18) :10344~10349

[20] 李连达, 张荣利, 张 旋, 等.津优力对中国小型猪冠状动脉栓塞心肌梗塞的治疗作用[J].中国新药杂志, 2003, 12 (9) :724~727 链接1

[21] 李连达, 张荣利, 张 旋, 等.津优力对大鼠心肌梗塞治疗作用的研究[J].中国新药杂志, 2003, 12 (9) :721~724

[22] KolletO , ShivtielS , ChenYQ , etal.HGF , SDF -1, andMMP -9areinvolvedinstress inducedhumanCD34+ stemcellrecruitmenttotheliver[J].JClinInvest, 2003, 112 (1) :160~169

[23] MunvCE , SoonpaaMH , ReinecheH , etal.Heamatopoieticstemcellsdonottransdifferentiateintocardiacmyocytesinmyocardialinfarcts[J].Nature, 2004, 428 (6983) :664~668

相关研究