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《中国工程科学》 >> 2008年 第10卷 第5期

参与中文配对词语联想学习记忆的脑区和神经机制——脑功能磁共振的研究

1. 广州南方医科大学珠江医院,广州 510282;

2. 广州华南师范大学信息光电子科技 学院,广州 510631;

3. 广州南方医科大学南方医院神经内科,广州 510515

资助项目 :国家“九七三”计划资助项目(2006CD504505); NSCF(30270431); NSGF (013069) 收稿日期: 2007-02-13 发布日期: 2008-05-15 16:42:33.000

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摘要

通过脑功能磁共振技术,研究健康人参与语言的词语配对联想学习记忆任务的脑区和神经机制。对16名右利手健康志愿者进行一项词语配对联想学习记忆任务作业的同时,进行脑功能磁共振扫描。实验采用组块设计,实验任务(包括记忆编码相和记忆提取相)与对照任务(共两个相)交替进行;数据采用SPM99软件进行数据分析和脑功能区定位。结果表明:左侧额叶,特别是左侧额叶的额中下回和枕叶的18,19区在词语联想学习记忆的编码阶段中起重要作用;而左侧顶上小叶、缘上回和角回则在进行记忆提取阶段起重要作用;左侧纹状体边缘区参与了人脑词语联想学习记忆作业的编码阶段。揭示了人大脑完成语言联想学习记忆任务时,除额、顶、枕和颞叶的皮层结构参与外,还新发现有皮层下结构如纹状体参与了词语联想学习记忆。在配对词语的编码和提取阶段,激活的脑区有所变化,显示了这两个语言阶段的神经活动变化机制。

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