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Eco-innovative design approach: Integrating quality and environmental aspects in prioritizing and solving

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《机械工程前沿（英文）》 2014年 第9卷 第3期   页码 203-217 doi: 10.1007/s11465-014-0308-8

摘要：

This study proposes an eco-innovative design process taking into consideration quality and environmental aspects in prioritizing and solving technical engineering problems. This approach provides a synergy between the Life Cycle Assessment (LCA), the non-quality matrix, the Theory of Inventive Problem Solving (TRIZ), morphological analysis and the Analytical Hierarchy Process (AHP). In the sequence of these tools, LCA assesses the environmental impacts generated by the system. Then, for a better consideration of environmental aspects, a new tool is developed, the non-quality matrix, which defines the problem to be solved first from an environmental point of view. The TRIZ method allows the generation of new concepts and contradiction resolution. Then, the morphological analysis offers the possibility of extending the search space of solutions in a design problem in a systematic way. Finally, the AHP identifies the promising solution(s) by providing a clear logic for the choice made. Their usefulness has been demonstrated through their application to a case study involving a centrifugal spreader with spinning discs.

关键词： eco-innovation     non-quality matrix     TRIZ     composted product spreading    

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Non-negativematrix factorization based unmixing for principal component transformed hyperspectral data

Xiu-rui GENG,Lu-yan JI,Kang SUN

《信息与电子工程前沿（英文）》 2016年 第17卷 第5期   页码 403-412 doi: 10.1631/FITEE.1600028

摘要： Non-negative matrix factorization (NMF) has been widely used in mixture analysis for hyperspectral remote sensing. When used for spectral unmixing analysis, however, it has two main shortcomings: (1) since the dimensionality of hyperspectral data is usually very large, NMF tends to suffer from large computational complexity for the popular multiplicative iteration rule; (2) NMF is sensitive to noise (outliers), and thus the corrupted data will make the results of NMF meaningless. Although principal component analysis (PCA) can be used to mitigate these two problems, the transformed data will contain negative numbers, hindering the direct use of the multiplicative iteration rule of NMF. In this paper, we analyze the impact of PCA on NMF, and find that multiplicative NMF can also be applicable to data after principal component transformation. Based on this conclusion, we present a method to perform NMF in the principal component space, named ‘principal component NMF’ (PCNMF). Experimental results show that PCNMF is both accurate and time-saving.

关键词： Non-negative matrix factorization (NMF)     Principal component analysis (PCA)     Endmember     Hyperspectral    

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adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer: a randomized, non-inferiority

《医学前沿（英文）》 2023年 第17卷 第1期   页码 93-104 doi: 10.1007/s11684-021-0892-z

摘要： We conducted a prospective study to assess the non-inferiority of adjuvant chemotherapy alone versus adjuvant concurrent chemoradiotherapy (CCRT) as an alternative strategy for patients with early-stage (FIGO 2009 stage IB–IIA) cervical cancer having risk factors after surgery. The condition was assessed in terms of prognosis, adverse effects, and quality of life. This randomized trial involved nine centers across China. Eligible patients were randomized to receive adjuvant chemotherapy or CCRT after surgery. The primary end-point was progression-free survival (PFS). From December 2012 to December 2014, 337 patients were subjected to randomization. Final analysis included 329 patients, including 165 in the adjuvant chemotherapy group and 164 in the adjuvant CCRT group. The median follow-up was 72.1 months. The three-year PFS rates were both 91.9%, and the five-year OS was 90.6% versus 90.0% in adjuvant chemotherapy and CCRT groups, respectively. No significant differences were observed in the PFS or OS between groups. The adjusted HR for PFS was 0.854 (95% confidence interval 0.415–1.757; P = 0.667) favoring adjuvant chemotherapy, excluding the predefined non-inferiority boundary of 1.9. The chemotherapy group showed a tendency toward good quality of life. In comparison with post-operative adjuvant CCRT, adjuvant chemotherapy treatment showed non-inferior efficacy in patients with early-stage cervical cancer having pathological risk factors. Adjuvant chemotherapy alone is a favorable alternative post-operative treatment.

关键词： chemotherapy     cervical cancer     lymph node metastasis     concurrent chemoradiotherapy     quality of life    

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Decellularized extracellular matrix mediates tissue construction and regeneration

《医学前沿（英文）》 2022年 第16卷 第1期   页码 56-82 doi: 10.1007/s11684-021-0900-3

摘要： Contributing to organ formation and tissue regeneration, extracellular matrix (ECM) constituents provide tissue with three-dimensional (3D) structural integrity and cellular-function regulation. Containing the crucial traits of the cellular microenvironment, ECM substitutes mediate cell–matrix interactions to prompt stem-cell proliferation and differentiation for 3D organoid construction in vitro or tissue regeneration in vivo. However, these ECMs are often applied generically and have yet to be extensively developed for specific cell types in 3D cultures. Cultured cells also produce rich ECM, particularly stromal cells. Cellular ECM improves 3D culture development in vitro and tissue remodeling during wound healing after implantation into the host as well. Gaining better insight into ECM derived from either tissue or cells that regulate 3D tissue reconstruction or organ regeneration helps us to select, produce, and implant the most suitable ECM and thus promote 3D organoid culture and tissue remodeling for in vivo regeneration. Overall, the decellularization methodologies and tissue/cell-derived ECM as scaffolds or cellular-growth supplements used in cell propagation and differentiation for 3D tissue culture in vitro are discussed. Moreover, current preclinical applications by which ECM components modulate the wound-healing process are reviewed.

关键词： decellularized extracellular matrix     3D culture     organoids     tissue repair    

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Perspective of mixed matrix membranes for carbon capture

Shinji Kanehashi, Colin A. Scholes

《化学科学与工程前沿（英文）》 2020年 第14卷 第3期   页码 460-469 doi: 10.1007/s11705-019-1881-5

摘要： Polymeric membrane-based gas separation has found wide applications in industry, such as carbon capture, hydrogen recovery, natural gas sweetening, as well as oxygen enrichment. Commercial gas separation membranes are required to have high gas permeability and selectivity, while being cost-effective to process. Mixed matrix membranes (MMMs) have a composite structure that consists of polymers and fillers, therefore featuring the advantages of both materials. Much effort has been made to improve the gas separation performance of MMMs as well as general membrane properties, such as mechanical strength and thermal stability. This perspective describes potential use of MMMs for carbon capture applications, explores their limitations in fabrication and methods to overcome them, and addresses their performance under industry gas conditions.

关键词： membranes     polymeric     mixed matrix     impurities    

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Strengthening of reinforced concrete beams using fiber-reinforced cementitious matrix systems fabricated

《结构与土木工程前沿（英文）》   页码 1100-1116 doi: 10.1007/s11709-023-0967-9

摘要： The performance of a new fiber-reinforced cementitious matrix (FRCM) system developed using custom-designed mortar and fabrics is investigated in this study. The behavior of this system is evaluated in terms of both the flexural and shear strengthening of reinforced concrete beams. Eight beams are designed to assess the effectiveness of the FRCM system in terms of flexural strengthening, and four specimens are designed to investigate their shear behavior. The parameters investigated for flexural strengthening are the number of layers, span/depth ratio, and the strengthening method. Unlike previous studies, custom fabrics with similar axial stiffness are used in all strengthening methods in this study. In the shear-strengthened specimens, the effects of the span/depth ratio and strengthening system type (fiber-reinforced polymer (FRP) or FRCM) are investigated. The proposed FRCM system exhibits desirable flexural and shear strengthening for enhancing the load capacity, provides sufficient bonding with the substrate, and prevents premature failure modes. Considering the similar axial stiffness of fabrics used in both FRCM and FRP systems and the higher load capacity of specimens strengthened by the former, cement-based mortar performs better than epoxy.

关键词： fiber-reinforced cementitious matrix     flexural strengthening     shear strengthening     carbon fiber-reinforced polymer     shear span    

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A dynamic model of mobile concrete pump boom based on discrete time transfer matrix method

Wu REN, Yunxin WU, Zhaowei ZHANG

《机械工程前沿（英文）》 2013年 第8卷 第4期   页码 360-366 doi: 10.1007/s11465-013-0280-8

摘要：

Mobile concrete pump boom is typical multi-body large-scale motion manipulator. Due to posture constantly change in working process, kinematic rule and dynamic characteristic are difficult to solve. A dynamics model of a mobile concrete pump boom is established based on discrete time transfer matrix method (DTTMM). The boom system is divided into sub-structure A and sub-structure B. Sub-structure A is composed by the 1st boom and hydraulic actuator as well as the support. And sub-structure B is consists of the other three booms and corresponding hydraulic actuators. In the model, the booms and links are regarded as rigid elements and the hydraulic cylinders are equivalent to spring-damper. The booms are driven by the controllable hydraulic actuators. The overall dynamic equation and transfer matrix of the model can be assembled by sub-structures A and B. To get a precise result, step size and integration parameters are studied then. Next the tip displacement is calculated and compared with the result of ADAMS software. The displacement and rotation angle curves of the proposed method fit well with the ADAMS model. Besides it is convenient in modeling and saves time. So it is suitable for mobile concrete pump boom real-time monitoring and dynamic analysis. All of these provide reference to boom optimize and engineering application of such mechanisms.

关键词： multi-body     mobile concrete pump boom     discrete time transfer matrix method (DTTMM)     kinematic     dynamic     tip displacement    

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Glycosylation of dentin matrix protein 1 is critical for fracture healing via promoting chondrogenesis

Hui Xue, Dike Tao, Yuteng Weng, Qiqi Fan, Shuang Zhou, Ruilin Zhang, Han Zhang, Rui Yue, Xiaogang Wang, Zuolin Wang, Yao Sun

《医学前沿（英文）》 2019年 第13卷 第5期   页码 575-589 doi: 10.1007/s11684-019-0693-9

摘要： Fractures are frequently occurring diseases that endanger human health. Crucial to fracture healing is cartilage formation, which provides a bone-regeneration environment. Cartilage consists of both chondrocytes and extracellular matrix (ECM). The ECM of cartilage includes collagens and various types of proteoglycans (PGs), which play important roles in maintaining primary stability in fracture healing. The PG form of dentin matrix protein 1 (DMP1-PG) is involved in maintaining the health of articular cartilage and bone. Our previous data have shown that DMP1-PG is richly expressed in the cartilaginous calluses of fracture sites. However, the possible significant role of DMP1-PG in chondrogenesis and fracture healing is unknown. To further detect the potential role of DMP1-PG in fracture repair, we established a mouse fracture model by using a glycosylation site mutant DMP1 mouse (S89G-DMP1 mouse). Upon inspection, fewer cartilaginous calluses and down-regulated expression levels of chondrogenesis genes were observed in the fracture sites of S89G-DMP1 mice. Given the deficiency of DMP1-PG, the impaired IL-6/JAK/STAT signaling pathway was observed to affect the chondrogenesis of fracture healing. Overall, these results suggest that DMP1-PG is an indispensable proteoglycan in chondrogenesis during fracture healing.

关键词： fracture     extracellular matrix     dentin matrix protein 1     proteoglycan     cartilage    

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Role of salivary matrix metalloproteinase-8 (MMP-8) in chronic periodontitis diagnosis

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《医学前沿（英文）》 2015年 第9卷 第1期   页码 72-76 doi: 10.1007/s11684-014-0347-x

摘要：

Periodontitis is an inflammatory disease of the periodontium. Any imbalance between the matrix metalloproteinases (MMPs) secreted by neutrophils and tissue inhibitors initiates the destruction of collagen in gum tissue, leading to chronic periodontitis. This study aimed to correlate salivary levels of MMP-8 and periodontal parameters of chronic periodontitis to establish MMP-8 as a noninvasive marker for the early diagnosis of chronic periodontitis. The study involved 40 subjects visiting the periodontic OPD of Dr. Ziauddin Ahmad Dental College and Hospital, located in Aligarh, U.P., India, from 2011 to 2012. The subjects were divided into two groups: group I consisted of 20 periodontally healthy subjects (controls) while group II consisted of 20 patients with chronic periodontitis. Chronic periodontitis was assessed on the basis of several periodontal parameters, including pocket probing depth (PPD), clinical attachment level (CAL), gingival index (GI), and plaque index (PI). Around 3 ml of unstimulated and whole expectorated saliva was collected for MMP-8 estimation by ELISA using Quantikine human total MMP-8 immunoassay kits. Data were analyzed using STATISTICA (Windows version 6) software. Salivary MMP-8 levels of groups I and II were 190.91±143.89 ng/ml and 348.26±202.1 ng/ml, respectively. The MMP-8 levels and periodontal status (PPD, CAL, GI, and PI) of groups I and II showed positive and significant correlations (for PPD, r = 0.63, P<0.001; for CAL, r = 0.54, P<0.001; for GI, r = 0.49, P<0.001; and for PI, r = 0.63, P<0.001). The results of this study demonstrate elevated concentrations of MMP-8 in individuals with chronic periodontitis.

关键词： matrix metalloproteinase-8     chronic periodontitis     pocket probing depth     clinical attachment level     gingival index     plaque index    

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Studies of fiber-matrix debonding

Navneet DRONAMRAJU,Johannes SOLASS,Jörg HILDEBRAND

《结构与土木工程前沿（英文）》 2015年 第9卷 第4期   页码 448-456 doi: 10.1007/s11709-015-0316-8

摘要： In this paper, the debonding of a single fiber-matrix system of carbon fiber reinforced composite (CFRP) AS4/Epson 828 material is studied using Cohesive Zone Model (CZM). The effect of parameters namely, maximum tangential contact stress, tangential slip distance and artificial damping coefficient on the debonding length at the interface of the fiber-matrix is analyzed. Contact elements used in the CZM are coupled based on a bilinear stress-strain curve. Load is applied on the matrix, tangential to the interface. Hence, debonding is observed primarily in Mode II. Wide range of values are considered to study the inter-dependency of the parameters and its effect on debonding length. Out of the three parameters mentioned, artificial damping coefficient and tangential slip distance significantly affect debonding length. A thorough investigation is recommended for case wise interface debonding analysis, to estimate the optimal parametric values while using CZM.

关键词： single fibre     cohesive zone model     interface debonding     carbon fiber reinforced composite (CFRP)    

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A novel cataplasma matrix of traditional Chinese medicine

Jing TIAN, Xiaolei ZHANG, Xueqin ZHOU,

《化学科学与工程前沿（英文）》 2010年 第4卷 第1期   页码 91-95 doi: 10.1007/s11705-009-0304-4

摘要： The aim of this paper was to develop a cataplasma matrix that can be applicable to both watersoluble and liposoluble drugs. The gellan gum and konjaku were employed as the scaffold materials of the matrix. With polyacrylic acid sodium and oligosaccharides as tacktifier, the formula of the cataplasma matrix was optimized in the orthogonal method as: gellan gum 0.4 g, xanthan€gum 0.03 g, konjac glue 0.1 g, glycerin 4 g, Gluco-Adhesive T (GAT) 6 g, Gluco-Adhesive E (GAE) 6 g, polyacrylic acid sodium 0.22 g, and sorbitol 3 g. The 180° peel strength, the tensile strength and the elongation at break was 3.043 N, 0.275 MPa and 91.05%, respectively. Furthermore, the drug-compatibilities of the matrix were investigated with baicalin, berberine and curcumin, which were used as the models of hydrophilic, poor-water-soluble and hydrophobic ingredients. The drug contents could reach 4.12% , 2.42% and 3.75%, while the release rate were measured as, 361.79, 55.85 and 104.41 μg·cm·hfor baicalin, berberine and curcumin, respectively. These results indicated that the obtained matrix had good drug-compatibility and drug-release properties for different ingredients.

关键词： drug-release     applicable     berberine     curcumin     different    

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Long acting carmustine loaded natural extracellular matrix hydrogel for inhibition of glioblastoma recurrence

《化学科学与工程前沿（英文）》 2022年 第16卷 第4期   页码 536-545 doi: 10.1007/s11705-021-2067-5

摘要： Many scientific efforts have been made to penetrate the blood-brain barrier and target glioblastoma cells, but the outcomes have been limited. More attention should be given to local inhibition of recurrence after glioblastoma resection to meet real medical needs. A biodegradable wafer containing the chemotherapeutics carmustine (1,3-bis(2-chloroethyl)-1-nitrosourea, BCNU) was the only local drug delivery system approved for clinical glioblastoma treatment, but with a prolonged survival time of only two months and frequent side effects. In this study, to improve the sustained release and prolonged therapeutic effect of drugs for inhibiting tumor recurrence after tumor resection, both free BCNU and BCNU- poly (lactic-co-glycolic acid) (the ratio of lactic acid groups to glycolic acid groups is 75/25) nanoparticles were simultaneously loaded into natural extracellular matrix hydrogel from pigskin to prepare BCNU gels. The hydrogel was injected into the resection cavity of a glioblastoma tumor immediately after tumor removal in a fully characterized resection rat model. Free drugs were released instantly to kill the residual tumor cells, while drugs in nanoparticles were continuously released to achieve a continuous and effective inhibition of the residual tumor cells for 30 days. These combined actions effectively restricted tumor growth in rats. Thus, this strategy of local drug implantation and delivery may provide a reliable method to inhibit the recurrence of glioblastoma after tumor resection in vivo.

关键词： BCNU     glioblastoma recurrence     tumor resection     nanoparticles     hydrogel    

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基于含隐变量的贝叶斯网络质量相关局部加权的非平稳过程软测量方法 Research Articles

《信息与电子工程前沿（英文）》 2021年 第22卷 第9期   页码 1234-1246 doi: 10.1631/FITEE.2000426

摘要：

在工业过程中，软测量技术被广泛用于预测难以测量的质量变量。构建一个应对过程非平稳性的自适应模型非常必要。本文针对非平稳过程，设计了一种基于含有隐变量贝叶斯网络的质量相关局部加权软测量方法。提出一种有监督贝叶斯网络提取质量相关的隐变量，并应用于一种双层相似度测量算法。所提软测量方法试图通过质量相关信息为非平稳过程寻找到一般方法，且详细解释了局部相似度和窗口置信度的概念。通过一个数值算例和脱丁烷塔的应用验证了所提方法的性能。结果表明所提方法预测关键质量变量的精确度优于竞争方法。

关键词： 软测量；有监督贝叶斯网络；隐变量；局部加权建模；质量预测    

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From total quality management to Quality 4.0: A systematic literature review and future research agenda

《工程管理前沿（英文）》 2023年 第10卷 第2期   页码 191-205 doi: 10.1007/s42524-022-0243-z

摘要： Quality 4.0 is an emerging concept that has been increasingly appreciated because of the intensification of competition, continually changing customer requirements and technological evolution. It deals with aligning quality management practices with the emergent capabilities of Industry 4.0 to improve cost, time, and efficiency and increase product quality. This article aims to comprehensively review extant studies related to Quality 4.0 to uncover current research trends, distil key research topics, and identify areas for future research. Thus, 46 journal articles extracted from the Scopus database from 2017 to 2022 were collected and reviewed. A descriptive analysis was first performed according to the year-wise publication, sources of publication, and research methods. Then, the selected articles were analyzed and classified according to four research themes: Quality 4.0 concept, Quality 4.0 implementation, quality management in Quality 4.0, and Quality 4.0 model and application. By extracting the literature review findings, we identify the Quality 4.0 definitions and features, develop the quality curve theory, and highlight future research opportunities. This study supports practitioners, managers, and academicians in effectively recognizing and applying Quality 4.0 to enhance customer satisfaction, achieve innovation enterprise efficiency, and increase organizational competitiveness in the era of Industry 4.0.

关键词： quality management     Quality 4.0     Industry 4.0     literature review     predictive quality    

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numerical framework for underground structures in layered ground under inclined P-SV waves using stiffness matrix

《结构与土木工程前沿（英文）》 2023年 第17卷 第1期   页码 10-24 doi: 10.1007/s11709-022-0904-3

摘要： A numerical framework was proposed for the seismic analysis of underground structures in layered ground under inclined P-SV waves. The free-field responses are first obtained using the stiffness matrix method based on plane-wave assumptions. Then, the domain reduction method was employed to reproduce the wavefield in the numerical model of the soil–structure system. The proposed numerical framework was verified by providing comparisons with analytical solutions for cases involving free-field responses of homogeneous ground, layered ground, and pressure-dependent heterogeneous ground, as well as for an example of a soil–structure interaction simulation. Compared with the viscous and viscous-spring boundary methods adopted in previous studies, the proposed framework exhibits the advantage of incorporating oblique incident waves in a nonlinear heterogeneous ground. Numerical results show that SV-waves are more destructive to underground structures than P-waves, and the responses of underground structures are significantly affected by the incident angles.

关键词： underground structures     seismic response     stiffness matrix method     domain reduction method     P-SV waves    

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标题 作者 时间 类型 操作

Eco-innovative design approach: Integrating quality and environmental aspects in prioritizing and solving

null

期刊论文

Non-negativematrix factorization based unmixing for principal component transformed hyperspectral data

Xiu-rui GENG,Lu-yan JI,Kang SUN

期刊论文

adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer: a randomized, non-inferiority

期刊论文

Decellularized extracellular matrix mediates tissue construction and regeneration

期刊论文

Perspective of mixed matrix membranes for carbon capture

Shinji Kanehashi, Colin A. Scholes

期刊论文

Strengthening of reinforced concrete beams using fiber-reinforced cementitious matrix systems fabricated

期刊论文

A dynamic model of mobile concrete pump boom based on discrete time transfer matrix method

Wu REN, Yunxin WU, Zhaowei ZHANG

期刊论文

Glycosylation of dentin matrix protein 1 is critical for fracture healing via promoting chondrogenesis

Hui Xue, Dike Tao, Yuteng Weng, Qiqi Fan, Shuang Zhou, Ruilin Zhang, Han Zhang, Rui Yue, Xiaogang Wang, Zuolin Wang, Yao Sun

期刊论文

Role of salivary matrix metalloproteinase-8 (MMP-8) in chronic periodontitis diagnosis

null

期刊论文

Studies of fiber-matrix debonding

Navneet DRONAMRAJU,Johannes SOLASS,Jörg HILDEBRAND

期刊论文

A novel cataplasma matrix of traditional Chinese medicine

Jing TIAN, Xiaolei ZHANG, Xueqin ZHOU,

期刊论文

Long acting carmustine loaded natural extracellular matrix hydrogel for inhibition of glioblastoma recurrence

期刊论文

基于含隐变量的贝叶斯网络质量相关局部加权的非平稳过程软测量方法

期刊论文

From total quality management to Quality 4.0: A systematic literature review and future research agenda

期刊论文

numerical framework for underground structures in layered ground under inclined P-SV waves using stiffness matrix

期刊论文