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The role of RAS effectors in BCR/ABL induced chronic myelogenous leukemia
null
《医学前沿(英文)》 2013年 第7卷 第4期 页码 452-461 doi: 10.1007/s11684-013-0304-0
BCR/ABL is the causative agent of chronic myelogenous leukemia (CML). Through structure/function analysis, several protein motifs have been determined to be important for the development of leukemogenesis. Tyrosine177 of BCR is a Grb2 binding site required for BCR/ABL-induced CML in mice. In the current study, we use a mouse bone marrow transduction/transplantation system to demonstrate that addition of oncogenic NRAS (NRASG12D) to a vector containing a BCR/ABLY177F mutant “rescues” the CML phenotype rapidly and efficiently. To further narrow down the pathways downstream of RAS that are responsible for this rescue effect, we utilize well-characterized RAS effector loop mutants and determine that the RAL pathway is important for rapid induction of CML. Inhibition of this pathway by a dominant negative RAL is capable of delaying disease progression. Results from the present study support the notion of RAL inhibition as a potential therapy for BCR/ABL-induced CML.
Effects of eggshell addition on calcium-deficient acid soils contaminated with heavy metals
Weiqi Luo, Yanping Ji, Lu Qu, Zhi Dang, Yingying Xie, Chengfang Yang, Xueqin Tao, Jianmin Zhou, Guining Lu
《环境科学与工程前沿(英文)》 2018年 第12卷 第3期 doi: 10.1007/s11783-018-1026-y
关键词: Heavy metals Eggshell Acid soil remediation BCR sequential extraction
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