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EEG-controlled functional electrical stimulation rehabilitation for chronic stroke: system design and

《医学前沿（英文）》 2021年第15卷第5期页码 740-749 doi: 10.1007/s11684-020-0794-5

摘要： Stroke is one of the most serious diseases that threaten human life and health. It is a major cause of death and disability in the clinic. New strategies for motor rehabilitation after stroke are undergoing exploration. We aimed to develop a novel artificial neural rehabilitation system, which integrates brain--computer interface (BCI) and functional electrical stimulation (FES) technologies, for limb motor function recovery after stroke. We conducted clinical trials (including controlled trials) in 32 patients with chronic stroke. Patients were randomly divided into the BCI-FES group and the neuromuscular electrical stimulation (NMES) group. The changes in outcome measures during intervention were compared between groups, and the trends of ERD values based on EEG were analyzed for BCI-FES group. Results showed that the increase in Fugl Meyer Assessment of the Upper Extremity (FMA-UE) and Kendall Manual Muscle Testing (Kendall MMT) scores of the BCI-FES group was significantly higher than that in the sham group, which indicated the practicality and superiority of the BCI-FES system in clinical practice. The change in the laterality coefficient (LC) values based on μ-ERD (ΔLC_m_-ERD) had high significant positive correlation with the change in FMA-UE(r= 0.6093, P=0.012), which provides theoretical basis for exploring novel objective evaluation methods.

关键词： brain–computer interface functional electrical stimulation electroencephalogram laterality coefficient chronic stroke

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EEG controlled neuromuscular electrical stimulation of the upper limb for stroke patients

Hock Guan TAN, Cheng Yap SHEE, Keng He KONG, Cuntai GUAN, Wei Tech ANG

《机械工程前沿（英文）》 2011年第6卷第1期页码 71-81 doi: 10.1007/s11465-011-0207-1

摘要：

This paper describes the Brain Computer Interface (BCI) system and the experiments to allow post-acute (<3 months) stroke patients to use electroencephalogram (EEG) to trigger neuromuscular electrical stimulation (NMES)-assisted extension of the wrist/fingers, which are essential pre-requisites for useful hand function. EEG was recorded while subjects performed motor imagery of their paretic limb, and then analyzed to determine the optimal frequency range within the -rhythm, with the greatest attenuation. Aided by visual feedback, subjects then trained to regulate their -rhythm EEG to operate the BCI to trigger NMES of the wrist/finger. 6 post-acute stroke patients successfully completed the training, with 4 able to learn to control and use the BCI to initiate NMES. This result is consistent with the reported BCI literacy rate of healthy subjects. Thereafter, without the loss of generality, the controller of the NMES is developed and is based on a model of the upper limb muscle (biceps/triceps) groups to determine the intensity of NMES required to flex or extend the forearm by a specific angle. The muscle model is based on a phenomenological approach, with parameters that are easily measured and conveniently implemented.

关键词： brain computer interface neuromuscular electrical stimulation stroke musculoskeletal modeling

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电刺激小脑顶核与中枢神经源性神经保护

董为伟

《中国工程科学》 2001年第3卷第11期页码 32-38

摘要：

电刺激小脑顶核为一种重要的条件性中枢神经源性神经保护途径，文章介绍了中枢神经源性神经保护及其机制，神经保护特点及所涉及的解剖部位；重点讨论电刺激小脑顶核对缺血性脑损伤的神经保护机理，并展望其临床应用及研究前景。

关键词：神经保护条件性小脑顶核电刺激脑缺血

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The impact of different voltage application modes on biodegradation of chloramphenicol and shift of microbial community structure

《环境科学与工程前沿（英文）》 2022年第16卷第11期 doi: 10.1007/s11783-022-1576-x

摘要：

● Presented coupled system enhanced biodegradation of antibiotic chloramphenicol.

关键词： Electrical stimulation Biodegradation Microbial community Chloramphenicol

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Jisheng Han, Cailian Cui, Liuzhen Wu

《医学前沿（英文）》 2011年第5卷第2期页码 141-150 doi: 10.1007/s11684-011-0136-8

摘要： Drug addiction is a chronic brain disorder characterized by withdrawal symptoms that occur during drug abstinence and a high tendency of relapse. Compared with the currently available pharmacological interventions, acupuncture therapy has the potential to help drug addicts stay away from drugs without major adverse side effects. It has taken decades of research to optimize the parameters of electrical acupoint stimulation for detoxification and for relapse prevention, as well as to establish a safe and easy procedure by which drug addicts can use it on themselves. The discovery that acupuncture can trigger the release of opioid substances from the brain in the 1970s provided the inspiration. Following this, basic research on animals made it possible to understand the mechanisms of action and establish the procedure for treating drug addictions. This article reviews the past, present, and foreseeable future regarding the use of acupuncture-related technique for the treatment of opiate addiction from the perspective of translational medicine.

关键词： morphine dependence withdrawal addiction dynorphins acupuncture electroacupuncture transcutaneous electrical acupoint stimulation (TEAS) enkephalins endorphins

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Repetitive transcranial magnetic stimulation causes significant changes of chemical substances in the

GUO Tiecheng, CAO Xuebing, XIA Limin

《医学前沿（英文）》 2008年第2卷第4期页码 406-409 doi: 10.1007/s11684-008-0078-y

摘要： More and more studies have reported the usefulness of repetitive transcranial magnetic stimulation (rTMS) in the treatment of stroke patients. This article is to explore if rTMS can cause changes of such chemical substances as N-acetylaspartate (NAA), choline (Cho) and creatine (Cr) in the surrounding area of experimental intracerebral hematoma of rabbits. A total of 36 rabbits were randomly divided into 3 groups: a control group (group A), a sham rTMS group (group B) and an rTMS group (group C). The experimental intracerebral hemorrhage (ICH) was induced by intracerebral injection of self-body blood of the animals in groups B and C, while those of the group A serving as controls were injected with normal saline. The rabbits of groups B and C were treated with sham and real rTMS, respectively, but those of group A were not. The contents of chemical substances including NAA, Cho and Cr in the perihematomal brain tissues were measured by using H-magnetic resonance spectroscopy (H-MRS) 12 hours, 72 hours, 1 week and 2 weeks after the experimental ICH was induced. The results show that the contents of NAA, Cr and NAA/Cr ratio were decreased significantly, but Cho, Cho/Cr increased significantly in groups B and C ( < 0.01) as compared against those in group A. A comparison between the groups B and C revealed that the contents of NAA, Cr, NAA/Cr were higher, but Cho and Cho/Cr were significantly lower in group C than those in group B ( < 0.01). It is concluded that rTMS could result in changes of the chemical substance contents in perihematomal brain tissues, which leads to neuroprotective effects in the brain.

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CHARACTERISTICS OF HERBIVORY/WOUND-ELICITED ELECTRICAL SIGNAL TRANSDUCTION IN TOMATO

《农业科学与工程前沿（英文）》 2021年第8卷第2期

摘要：

Electrical signals commonly occur in plants in response to various environmental changes and have a dominant function in plant acclimation. The transduction of wound-elicited electrical signals in the model plant species Arabidopsis has been characterized but the characteristics of electrical signal transduction in response to herbivory or wounding in crop species remain unknown. Here, the features of electrical signals elicited by insect herbivory and wounding in tomato were investigated. Unlike those in Arabidopsis, wounding tomato leaves did not cause leaf-to-leaf electrical signal transduction. In contrast, electrical signals elicited in response to petiole wounding were stronger and more strongly transduced. Leaflet wounding also activated electrical signal transduction and jasmonic acid (JA) signaling within the whole compound leaf. It was also demonstrated that tomato glutamate receptor-like 3.3 (GLR3.3) and GLR3.5 mediated leaflet-to-leaflet electrical signal transduction. Herbivory-induced JA accumulation and Helicoverpa armigera resistance were reduced in glr3.3/3.5 plants. This work reveals the nature of electrical signal transduction in tomato and emphasizes the key roles of GLR3.3 and GLR3.5 in electrical signal transduction and JA signaling activation.

关键词： electrical signal / glutamate receptor-like / herbivory / jasmonic acid / tomato

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Effect of repeated gonadotropin stimulation on ovarian reserves and proliferation of ovarian surface

Linlin LIANG, Bei XU, Guijin ZHU

《医学前沿（英文）》 2009年第3卷第2期页码 220-226 doi: 10.1007/s11684-009-0037-2

摘要： This study aimed to evaluate the effect of repeated ovarian stimulation (OS) on the ovarian follicular population and morphology in female mice and its influence on the embryo’s developmental ability, and the profile of the ovarian surface epithelium (OSE). A total of 75 mice were enrolled in this experiment and randomly assigned into three groups: repeated ovarian stimulated group [ =25; receiving 5 IU pregnant mare serum gonadotrophin (PMSG) and human chorionic gonadotropin (hCG) at 6 day intervals for 5 cycles]; single ovarian stimulated group ( =25; receiving 5 IU PMSG and hCG for 1 cycle), and control group ( =25; without additional treatment). The follicle number at various stages and the morphologies were recorded respectively in the three groups. The harvested oocytes or embryos, cleavage rate, good quality embryo rate, and blastocyst production rate were counted and calculated, and the proliferations of ovarian surface epithelium were evaluated respectively. In the three groups, the single ovarian stimulation treatment significantly increased the mean number of ovarian oocytes or embryos (39.25±10.77 one-cell embryos/female); on the other hand, repeated gonadotropin stimulation obtained the lowest mean number (5.15± 2.81 eggs/female, <0.01). Repeated ovarian stimulation also tended to decrease normal follicles of primary follicles (66.67%) and secondary follicles (72.86%), and got the lowest cleavage rate (67.47%), lowest good quality embryo rate (2.41%), and lowest blastocyst production rate (0). The OSE cells adjacent to the antral follicles and corpus luteum (CL) in the repeated ovarian stimulated group (81.8%) had a significantly higher proliferation rate than the other groups. The proliferation rate of the OSE in the single ovarian stimulated group (56.4%) was significantly higher than that in the control group (37.5%) ( <0.01). In conclusion, single ovarian stimulation may produce more oocytes/embryos. However, repeated gonadotropin stimulation may have a negative effect on the ovarian follicular quality, the number of mature retrieved oocytes, and the embryo quality, even increasing the chance of ovarian cancer.

关键词： gonadotropin-releasing hormone ovarian reserve embryo developmental ability ovarian surface epithelium

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Recycling Materials from Waste Electrical and Electronic Equipment

Jinhui Li

《环境科学与工程前沿（英文）》 2017年第11卷第5期 doi: 10.1007/s11783-017-1001-z

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Engineering Fronts in fields of Energy and Electrical Science and Technologies in the report of

《能源前沿（英文）》 doi: 10.1007/s11708-023-0868-6

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Fracture model for the prediction of the electrical percolation threshold in CNTs/Polymer composites

Yang SHEN, Pengfei HE, Xiaoying ZHUANG

《结构与土木工程前沿（英文）》 2018年第12卷第1期页码 125-136 doi: 10.1007/s11709-017-0396-8

摘要： In this paper, we propose a 3D stochastic model to predict the percolation threshold and the effective electric conductivity of CNTs/Polymer composites. We consider the tunneling effect in our model so that the unrealistic interpenetration can be avoided in the identification of the conductive paths between the CNTs inside the polymer. The results are shown to be in good agreement with reported experimental data.

关键词： electrical percolation CNTs/Polymer composites fracture model electric conductivity tunnelling effects

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Combination of steam-enhanced extraction and electrical resistance heating for efficient remediation

《环境科学与工程前沿（英文）》 2022年第16卷第11期 doi: 10.1007/s11783-022-1582-z

摘要：

● Coupling merits of SEE and ERH were explored by a laboratory-scale device.

关键词： Steam-enhanced extraction Electrical resistance heating Dense nonaqueous phase liquid Soil remediation Energy consumption

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Tailoring electrical conductivity of two dimensional nanomaterials using plasma for edge electronics:

Aswathy Vasudevan, Vasyl Shvalya, Aleksander Zidanšek, Uroš Cvelbar

《化学科学与工程前沿（英文）》 2019年第13卷第3期页码 427-443 doi: 10.1007/s11705-019-1805-4

摘要： Since graphene has been discovered, two-dimensional nanomaterials have attracted attention due to their promising tunable electronic properties. The possibility of tailoring electrical conductivity at the atomic level allows creating new prospective 2D structures for energy harvesting and sensing-related applications. In this respect, one of the most successful way to manipulate the physical properties of the aforementioned materials is related to the surface modification techniques employing plasma. Moreover, plasma-gaseous chemical treatment can provide a controlled change in the bandgap, increase sensitivity and significantly improve the structural stability of material to the environment as well. This review deals with recent advances in the modification of 2D carbon nanostructures for novel ‘edge’ electronics using plasma technology and processes.

关键词： graphene edge electronics 2D nanomaterials plasma electrical conductivity

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Study on electrical ignition and micro-explosion properties of HAN-based monopropellant droplet

Yonggang YU, Ming LI, Yanhuang ZHOU, Xin LU, Yuzhu PAN,

《能源前沿（英文）》 2010年第4卷第3期页码 430-435 doi: 10.1007/s11708-010-0010-4

摘要： In order to study the electrical ignition characteristics of hydroxylammonium nitrate (HAN)-based liquid propellant, an experimental device for the electrical heating ignition of a liquid propellant droplet was designed. By using a high speed camera system, the ignition properties of the LP1846 single droplet were observed at different electrical heating speeds. The results show that when the LP1846 droplet is electrified, it mainly goes through an evaporization process, a periodic expansion and contraction process, a stronger thermal decomposition process, and an ignition and combustion process. The periodic expansion and contraction process accompanies the droplet micro-explosion phenomenon, and the micro-explosion mechanism is formed mainly due to the overheated water component in LP1846. When peak load voltage is from 80 to 140V/s, the ignition delay of the LP1846 droplet is linearly shortened from 0.82 to 0.62s, but the flame is lighter. Based on the above experiments, a simplified model of the electrical heating ignition of the LP1846 single droplet is established.

关键词： liquid propellant electrical ignition ignition delay time transient measurement

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Power sources and electrical recharging strategies for implantable medical devices

WEI Xiaojuan, LIU Jing

《能源前沿（英文）》 2008年第2卷第1期页码 1-13 doi: 10.1007/s11708-008-0016-3

摘要： Implantable medical devices (IMDs) are critically requested for the survival of patients subject to certain serious diseases such as bradycardia, fibrillation, diabetes, and disability, etc. Appropriate working of an active implantable medical device (IMD) heavily relies on the continuous supply of electricity. In this sense, long-term powering and recharging of an IMD via a highly safe, efficient and convenient way is, therefore, extremely important in clinics. Several conventional batteries, such as lithium cell, nuclear cell and bio-fuel cell, etc., have been developed to power IMDs. Meanwhile, the recharge of IMD from outside of the human body is also under investigation. In this paper, some of the most typical IMD batteries are reviewed. Their advantages and disadvantages are compared. In addition, several emerging innovations to recharge or directly drive the implanted batteries, including electromagnetic energy transmission, piezoelectric power generation, thermoelectric devices, ultrasonic power motors, radio frequency recharging and optical recharging methods, etc., are also discussed. Some fundamental and practical issues thus involved are summarized, and future prospects in this area are made.

关键词： generation bio-fuel ultrasonic piezoelectric conventional

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标题作者时间类型操作

EEG-controlled functional electrical stimulation rehabilitation for chronic stroke: system design and

期刊论文

EEG controlled neuromuscular electrical stimulation of the upper limb for stroke patients

Hock Guan TAN, Cheng Yap SHEE, Keng He KONG, Cuntai GUAN, Wei Tech ANG

期刊论文

电刺激小脑顶核与中枢神经源性神经保护

董为伟

期刊论文

The impact of different voltage application modes on biodegradation of chloramphenicol and shift of microbial community structure

期刊论文

Acupuncture-related techniques for the treatment of opiate addiction: a case of translational medicine

Jisheng Han, Cailian Cui, Liuzhen Wu

期刊论文

Repetitive transcranial magnetic stimulation causes significant changes of chemical substances in the

GUO Tiecheng, CAO Xuebing, XIA Limin

期刊论文

CHARACTERISTICS OF HERBIVORY/WOUND-ELICITED ELECTRICAL SIGNAL TRANSDUCTION IN TOMATO

期刊论文

Effect of repeated gonadotropin stimulation on ovarian reserves and proliferation of ovarian surface

Linlin LIANG, Bei XU, Guijin ZHU

期刊论文

Recycling Materials from Waste Electrical and Electronic Equipment

Jinhui Li

期刊论文

Engineering Fronts in fields of Energy and Electrical Science and Technologies in the report of

期刊论文

Fracture model for the prediction of the electrical percolation threshold in CNTs/Polymer composites

Yang SHEN, Pengfei HE, Xiaoying ZHUANG

期刊论文

Combination of steam-enhanced extraction and electrical resistance heating for efficient remediation

期刊论文

Tailoring electrical conductivity of two dimensional nanomaterials using plasma for edge electronics:

Aswathy Vasudevan, Vasyl Shvalya, Aleksander Zidanšek, Uroš Cvelbar

期刊论文

Study on electrical ignition and micro-explosion properties of HAN-based monopropellant droplet

Yonggang YU, Ming LI, Yanhuang ZHOU, Xin LU, Yuzhu PAN,

期刊论文

Power sources and electrical recharging strategies for implantable medical devices

WEI Xiaojuan, LIU Jing

期刊论文

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