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HLA/RTI 2

Agent 1

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复杂系统 1

嵌合抗原受体（CAR） 1

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HLA 分布仿真扩展研究

吴泽彬,吴慧中,李蔚清

《中国工程科学》 2008年第10卷第7期页码 141-146

摘要：

分析HLA 扩展研究现状，针对HLA分布仿真互操作和重用的两个典型问题，结合Web 服务技术，将传统HLA仿真应用框架进行去耦处理，提出一个HLA 分布仿真扩展体系结构，基于pRTI 和AXIS 引擎实现原型系统，通过实例详细说明RTI 服务的封装部署以及RTI API 调用到SOAP 消息的映射。该扩展设计能够封装原有的RTI 库；将传统的HLA 分布仿真应用扩展到广域网环境；具有广泛的兼容能力，可以支持不同的系统平台，实现松散耦合、跨平台的分布式仿真系统。

关键词： HLA/RTI 分布仿真 Web 服务 SOAP 体系结构

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复杂系统计算机仿真的研究与设计

金士尧,李宏亮,党岗,王召福,刘晓建

《中国工程科学》 2002年第4卷第4期页码 52-57

摘要：

复杂系统与复杂性是21世纪的核心科学问题之一，并引入国家重点基础研究发展规划。基于复杂系统的复杂性和不确定性，很难想像可以采用传统朴素的还原论法进行可行性研究。推崇多智能主体的模糊计算机仿真来研究复杂系统的复杂性，并设计了一个基于多智能体的复杂系统分布仿真平台。

关键词：复杂系统计算机仿真 Agent HLA/RTI

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HLA and lung transplantation

Liya Ju, Caroline Suberbielle, Xiaofan Li, Nuala Mooney, Dominique Charron

《医学前沿（英文）》 2019年第13卷第3期页码 298-313 doi: 10.1007/s11684-018-0636-x

摘要： Lung transplantation is increasingly practiced for patients with end-stage lung disease. The successful outcome of solid organ transplantation today is severely impeded by the production of alloantibodies, mainly directed against the protein products of the HLA complex of the organ donor. While the association between antibody mediated rejection and allograft damage has been well established in renal and heart transplantation, it has not yet been well characterized in lung transplantation. This review addresses the question of HLA matching in lung transplantation and current knowledge of the allogenicity of different HLA class I and II antigens. The role of the antibody mediated immune response is discussed as well as the importance of pre-transplant or post-transplant circulating antibodies. Finally, potential mechanisms, which may act individually or in combination, of antibody mediated damage to solid organ transplants are considered.

关键词： human leukocyte antigen class I and II lung transplantation mismatch obliterans bronchiolitis alloantibody antibody mediated rejection

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DQB1*060101 may contribute to susceptibility to immunoglobulin A nephropathy in southern Han Chinese

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《医学前沿（英文）》 2016年第10卷第4期页码 507-516 doi: 10.1007/s11684-016-0475-6

摘要：

Immunoglobulin A nephropathy (IgAN) is a common form of chronic glomerulonephritis with unknown pathogenesis. Accumulating evidences have shown the ethnic-specific association between certain human leukocyte antigen (HLA) alleles and IgAN susceptibility. This study was designed to explore the relationship between HLA-DQB1 alleles and disease susceptibility and clinical manifestations of patients with IgAN in southern Han Chinese. A PCR sequence-based typing technique was used to detect HLA-DQB1 alleles in 217 IgAN patients and 229 healthy subjects. Clinical data were collected from each patient at the time of renal biopsy. Twenty HLA-DQB1 alleles were detected in IgAN patients and healthy subjects. High frequency of HLA-DQB1*060101 and low frequency of HLA-DQB1*030101 were observed in IgAN patients compared with healthy controls. Further stratification analysis revealed that the frequency of DQB1*060101 was significantly higher in patients with urine protein≥1.0 g/24 h than in patients with urine protein<1.0 g/24 h. In combination with our previous DRB1 results, we also analyzed the association of DRB1-DQB1 haplotypes with IgAN. We found that the frequency of haplotype DRB1*090102-DQB1*060101 was significantly higher [odds ratio (OR) = 4.409, Pc = 0.016], whereas that of HLA-DRB1*070101-DQB1*020101 was significantly lower (OR= 0.194, Pc = 0.016) compared with healthy controls. Our study indicated that HLA-DQB1*060101 alleles may be a potential predictor of high-risk IgAN susceptibility in Chinese Han population.

关键词： DQB1 human leukocyte antigen (HLA) IgA nephropathy haplotype association study

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嵌合抗原受体和调节性T细胞——移植中人类白细胞抗原特异性免疫抑制的潜力 Review

Sabrina Wright, Conor Hennessy, Joanna Hester, Fadi Issa

《工程（英文）》 2022年第10卷第3期页码 30-43 doi: 10.1016/j.eng.2021.10.018

摘要：

嵌合抗原受体（CAR）是基因工程领域的一项突破，它彻底改变了过继细胞疗法（ACT）领域。表达这些受体的细胞通过在合成的CAR构建体中包含抗原特异性结合区域而被重新定向到预定的靶点。程序化特异性细胞在肿瘤学领域的优势已被临床证明，与同类未修饰的细胞相比，这种细胞具有更高的准确性、效力与更少的脱靶效应。与常规T细胞（Tconvs）不同，调节性T细胞（Treg）在抑制免疫激活和调节宿主免疫反应方面发挥着重要作用。Treg 中CAR的表达被认为是治疗自身免疫和炎症性疾病、移植物抗宿主病（GVHD）和器官移植排斥反应的一种方法。在后者中，它们作为同种异体移植受者免疫耐受的介质具有巨大的潜力。然而，目前对CAR-Treg 工程的研究非常有限，并且关于治疗用途的最佳设计存在不确定性。本文综述了CAR-Treg 发展的理论基础、其对人类移植的意义、潜在的设计、安全性考虑因素，以及迄今为止CAR-Treg在移植模型中的对比。

关键词：嵌合抗原受体（CAR）调节性T细胞异性免疫 CAR设计基因编辑