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放射性药物 1

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The value of radionuclide hepatobiliary scintigraphy in combination with determination of bilirubin from

Sheng-Xuan LIU, Zhi-Hua HUANG

《医学前沿（英文）》 2010年第4卷第3期页码 342-345 doi: 10.1007/s11684-010-0099-1

摘要： The aim of this study was to investigate the value of technetium etifenin injection ( Tc-EHIDA) hepatobiliary scintigraphy in combination with determination of bilirubin from duodenal drainage in differential diagnosis between infantile hepatitis syndrome and biliary atresia. Tc-EHIDA hepatobiliary scintigraphy in combination with duodenal fluid examination was used for evaluation in 84 infants with persistent infantile jaundice. For diagnosing biliary atresia, the sensitivity and specificity of scintigraphy were 100% and 74.5%, respectively; the sensitivity and specificity of scintigraphy in combination with duodenal fluid examination were 100% and 100%, respectively. In conclusion, hepatobiliary scintigraphy, which is a noninvasive, safe, valuable examination method, in combination with examination of duodenal fluid, is of value for the differential diagnosis between infantile hepatitis syndrome and biliary atresia.

关键词： jaundice radionuclide hepatobiliary scintigraphy duodenal drainage

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A model of

Jingyu WANG,Hongwei FANG,Guojian HE,Lei HUANG

《环境科学与工程前沿（英文）》 2014年第8卷第6期页码 845-853 doi: 10.1007/s11783-014-0708-3

摘要： The impact on the environment of radionuclide release from nuclear power plants has attracted increased attention, especially after the accident at Fukushima Daiichi Nuclear Power Plant in Japan. Based on the mechanisms of adsorption/desorption at solid/liquid interfaces and a surface micromorphology model of sediments, a theoretical expression of the distribution coefficient is derived. This coefficient has significant effects on the distribution of radionuclide in seawater, suspended sediment and seabed sediment. is then used to simulate Sr transport in the sea near the Daya Bay Nuclear Power Plant. The simulation results are compared with field measurements of tidal level, current velocity, suspended sediment concentration and Sr concentrations in the same period. Overall, the simulated results agree well with the field measured data. Thus, the derived expression for is capable of interpreting realistic adsorption/desorption processes. What’s more, conclusion is drawn that about 40% Sr released by Daya Bay Nuclear Power Plant will be adsorbed by suspended sediment and 20% by seabed sediment, only about 40% Sr will remain in the sea near Daya Bay Nuclear Power Plant in South China Sea.

关键词： distribution coefficient Daya Bay hydrodynamic sediment transport radionuclide transport

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Magnetotactic bacteria: Characteristics and environmental applications

Xinjie Wang, Yang Li, Jian Zhao, Hong Yao, Siqi Chu, Zimu Song, Zongxian He, Wen Zhang

《环境科学与工程前沿（英文）》 2020年第14卷第4期 doi: 10.1007/s11783-020-1235-z

摘要： • Magnetotactic bacteria (MTB) synthesize magnetic nanoparticle within magnetosomes. • The morphologic and phylogenetic diversity of MTB were summarized. • Isolation and mass cultivation of MTB deserve extensive research for applications. • MTB can remove heavy metals, radionuclides, and organic pollutants from wastewater. Magnetotactic bacteria (MTB) are a group of Gram-negative prokaryotes that respond to the geomagnetic ﬁeld. This unique property is attributed to the intracellular magnetosomes, which contains membrane-bound nanocrystals of magnetic iron minerals. This review summarizes the most recent advances in MTB, magnetosomes, and their potential applications especially the environmental pollutant control or remediation. The morphologic and phylogenetic diversity of MTB were first introduced, followed by a critical review of isolation and cultivation methods. Past research has devoted to optimize the factors, such as oxygen, carbon source, nitrogen source, nutrient broth, iron source, and mineral elements for the growth of MTB. Besides the applications of MTB in modern biological and medical fields, little attention was made on the environmental applications of MTB for wastewater treatment, which has been summarized in this review. For example, applications of MTB as adsorbents have resulted in a novel magnetic separation technology for removal of heavy metals or organic pollutants in wastewater. In addition, we summarized the current advance on pathogen removal and detection of endocrine disruptor which can inspire new insights toward sustainable engineering and practices. Finally, the new perspectives and possible directions for future studies are recommended, such as isolation of MTB, genetic modification of MTB for mass production and new environmental applications. The ultimate objective of this review is to promote the applications of MTB and magnetosomes in the environmental fields.

关键词： Magnetotactic bacteria Magnetosome Heavy metal Radionuclide Organic pollutants

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我国放射性药物创新体系发展战略研究

彭述明,杨宇川,杨夏,钱达志,郑刚阳,赵宪庚

《中国工程科学》 2022年第24卷第6期页码 116-126 doi: 10.15302/J-SSCAE-2022.06.010

摘要：

核医学在多种疾病的诊疗及预后判断方面发挥着不可替代的作用；放射性药物（放药）是核医学发展的基石，相应体系化发展有助于加快放药创新与应用，保障人民身体健康。本文深入调研了数十年来放药研究方向的文献，实地走访了国内10 余家核医疗相关高校、研究院所、医院及企业，以邀请专家开展咨询交流与行业研讨等方式，相对全面地掌握了放药研制和应用领域的发展态势与格局。在分析国外放药发展现状、技术水平及趋势的基础上，总结了我国放药发展的基本情况并辨识了面临的迫切问题；从技术研发体系、技术监管体系两方面阐述了重点建设内容，提出了放药靶点研究及靶向结构开发，新型放射性标记，放药自动化、智能化、规模化可控制备，放药辐射剂量检测及评价、放药联合诊疗等关键技术突破点。研究建议，以临床为导向鼓励多学科交叉融合的创新发展，加快放药技术创新体系建设，加强放药研发专业化人才队伍建设，以此促进核医学水平的整体提升。

关键词：核医学放射性药物放药审评靶向药物核素诊疗