摘要：
In this paper, the influence of two typical ionic impurities (Na and Mg) is investigated with the focused beam reflectance measurement (FBRM) technique. In this system, the on-line FBRM is used as a tool for monitoring the crystallization process of cobalamin by measuring the chord length distribution of particles and the particle counts. It is noted that impurity Mg has a more significant effect than Na in crystal growth of the whole crystallization process. From the microscopic observation of crystals, Mg has an obvious effect on the crystal habit, while Na has little effect. In addition, the crystal habit changes can be monitored by particle vision measurement (PVM). Understanding these effects is helpful to aid optimization and improve process control.
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