Search | Engineering

订阅投稿

首页工程期刊工程焦点工程成就工程前沿关于我们 English

资源类型

期刊论文 3

年份

2019 1

2008 1

2007 1

关键词

作用机制 1

抗癌 1

疟疾 1

青蒿 1

检索范围：

排序：展示方式：

Crk-associated substrate, vascular smooth muscle and hypertension

TANG Dale

《医学前沿（英文）》 2008年第2卷第4期页码 323-331 doi: 10.1007/s11684-008-0062-6

摘要： Hypertension is characterized by vascular smooth muscle constriction and vascular remodeling involving cell migration, hypertrophy and growth. Crk-associated substrate (CAS), the first discovered member of the adapter protein CAS family, has been shown to be a critical cellular component that regulates various smooth muscle functions. In this review, the molecular structure and protein interactions of the CAS family members are summarized. Evidence for the role of CAS in the regulation of vascular smooth muscle contractility is presented. Contraction stimulation induces CAS phosphorylation on Tyr-410 in arterial smooth muscle, creating the binding site for the Src homology (SH) 2/SH3 protein CrkII, which activates neuronal Wiskott-Aldrich syndrome protein (N-WASP)-mediated actin assembly and force development. The functions of CAS in cell migration, hypertrophy and growth are also summarized. Abelson tyrosine kinase (Abl), c-Src, focal adhesion kinase (FAK), proline-rich tyrosine kinase 2 (PYK2), protein tyrosine phosphatase-proline, glutamate, serine and threonine sequence protein (PTP-PEST) and SHP-2 have been documented to coordinate the phosphorylation and dephosphorylation of CAS. The downstream signaling partners of CAS in the context of cell motility, hypertrophy, survival and growth are also discussed. These new findings establish the important role of CAS in the modulation of vascular smooth muscle functions. Furthermore, the upstream regulators of CAS may be new biologic targets for the development of more effective and specific treatment of cardiovascular diseases such as hypertension.

关键词： Contraction stimulation phosphatase-proline molecular structure discovered hypertension

HTML PDF 收藏

Growth responses of the newly-discovered Cd-hyperaccumulator Rorippa globosa and its accumulation characteristics

SUN Yuebing, ZHOU Qixing, WEI Shuhe, REN Liping

《环境科学与工程前沿（英文）》 2007年第1卷第1期页码 107-113 doi: 10.1007/s11783-007-0020-6

摘要： has been identified as a newly-found Cd-hyperaccumulating species. In the present study, growth responses of and its accumulation characteristics of Cd and As were examined under joint stress of Cd and As. The results showed that Cd and As had an antagonistic effect on enhancing the growth of plants and Cd uptake and accumulation under the low concentration Cd and As treatments. When the concentration of Cd in the soil was 10 mg/kg and the concentration of As was 50 mg/kg, the highest growing height of the plant was up to 35.9 cm and the dry weight of the shoots was up to 2.2 g/pot, respectively. Meanwhile, the accumulation of Cd in the leaves under the joint stress was higher than that at the same level under single Cd pollution. However, there were synergic adverse effects on plant growth and Cd uptake under the combined pollution from a high concentration of Cd and As. Meanwhile, the accumulation of As in the roots was greater than that in the shoots, the translocation factor (TF) was "d0.3 and the bioaccumulation factor (BF) was "d0.6, thus showing that had an excluding effect on As uptake. These results confirmed that had a strong tolerant ability to the joint stress of Cd and As, and the potential for phytoremediation of soils contaminated by Cd and As.

关键词： synergic adverse stress present study potential weight

HTML PDF 收藏

青蒿素——一种从中药中发现的神奇药物 Review

王继刚, 徐承超, 王彦钧, 李玉洁, 廖福龙, 姜廷良, 屠呦呦

《工程（英文）》 2019年第5卷第1期页码 32-39 doi: 10.1016/j.eng.2018.11.011

摘要：

青蒿素及其衍生物是治疗疟疾最重要且最具影响力的一类药物。自20世纪70年代初发现青蒿素以来，国际上在研究这种非凡的植物化学药物及探明其独特的化学和药理特性方面取得了巨大进展。现今，虽然青蒿素及其衍生物仍然是抗疟的支柱药物，它们的持续应用和发展也面临许多挑战。这些挑战包括青蒿素治疗疟疾过程中出现的耐药现象以及青蒿素在其它疾病中的应用。在这篇综述中，我们描述了青蒿素类药物的早期发现和发展过程、应用现状以及未来的发展前景。另外，我们总结了当前的青蒿素机制研究情况并提出了我们自己的看法，同时强调了机制研究对于青蒿素类药物在抗疟以及其它疾病治疗中的重要性。

关键词：青蒿作用机制疟疾抗癌