检索范围:
排序: 展示方式:
《医学前沿(英文)》 2022年 第16卷 第1期 页码 102-110 doi: 10.1007/s11684-021-0850-9
关键词: COVID-19 RAS inhibitor hypertension all-cause mortality
CHEN Guowei, XI Pengge, XU Deqian, YU Hanqing
《环境科学与工程前沿(英文)》 2007年 第1卷 第1期 页码 63-66 doi: 10.1007/s11783-007-0012-6
关键词: uncoupling coefficient Cu minimization presence uncoupling
null
《医学前沿(英文)》 2017年 第11卷 第3期 页码 403-409 doi: 10.1007/s11684-017-0522-y
Tissue factor pathway inhibitor (TFPI) is the main inhibitor of tissue factor-mediated coagulation. TFPI is expressed by endothelial and smooth muscle cells in the vasculature. Endothelium-derived TFPI has been reported to play a regulatory role in arterial thrombosis. However, the role of endogenous TFPI in vascular smooth muscle cells (VSMCs) in thrombosis and vascular disease development has yet to be elucidated. In this TFPIFlox mice crossbred with Sma–Cre mice were utilized to establish TFPI conditional knockout mice and to examine the effects of VSMC-directed TFPI deletion on development, hemostasis, and thrombosis. The mice with deleted TFPI in VSMCs (TFPISma) reproduced viable offspring. Plasma TFPI concentration was reduced 7.2% in the TFPISma mice compared with TFPIFlox littermate controls. Plasma TFPI concentration was also detected in the TFPITie2 (mice deleted TFPI in endothelial cells and cells of hematopoietic origin) mice. Plasma TFPI concentration of the TFPITie2 mice was 80.4% lower (P<0.001) than that of the TFPIFlox mice. No difference in hemostatic measures (PT, APTT, and tail bleeding) was observed between TFPISma and TFPIFlox mice. However, TFPISma mice had increased ferric chloride–induced arterial thrombosis compared with TFPIFlox littermate controls. Taken together, these data indicated that endogenous TFPI from VSMCs inhibited ferric chloride–induced arterial thrombosis without causing hemostatic effects.
关键词: arterial thrombosis conditional knockout mice tissue factor pathway inhibitor vascular smooth muscle cells
Estimating the effect of urease inhibitor on rice yield based on NDVI at key growth stages
Kailou LIU,Yazhen LI,Huiwen HU
《农业科学与工程前沿(英文)》 2014年 第1卷 第2期 页码 150-157 doi: 10.15302/J-FASE-2014028
关键词: normalized difference vegetation index (NDVI) N-(n-butyl) thiophosphoric triamide (NBPT) rice grain yield
《医学前沿(英文)》 2023年 第17卷 第2期 页码 275-289 doi: 10.1007/s11684-022-0945-y
关键词: epidermal growth factor receptor ErbB receptors HM781-36B nasopharyngeal carcinoma molecular targeted therapy cisplatin
Genomic regions associated with the sex-linked inhibitor of dermal melanin in Silkie chicken
Ming TIAN,Rui HAO,Suyun FANG,Yanqiang WANG,Xiaorong GU,Chungang FENG,Xiaoxiang HU,Ning LI
《农业科学与工程前沿(英文)》 2014年 第1卷 第3期 页码 242-249 doi: 10.15302/J-FASE-2014018
关键词: sex-linked inhibitor of dermal melanin (Id) Silkie chromosome Z
《医学前沿(英文)》 2022年 第16卷 第3期 页码 467-482 doi: 10.1007/s11684-021-0869-y
关键词: hepatocellular carcinoma cabozantinib primary resistance rapamycin
Medical oncology management of advanced hepatocellular carcinoma 2019: a reality check
Amy Lee, Fa-Chyi Lee
《医学前沿(英文)》 2020年 第14卷 第3期 页码 273-283 doi: 10.1007/s11684-019-0728-2
关键词: hepatocellular carcinoma tyrosine kinase inhibitor check point inhibitor anti-angiogenesis
Yang An, Chao Chen, Jundong Zhu, Pankaj Dwivedi, Yanjun Zhao, Zheng Wang
《化学科学与工程前沿(英文)》 2020年 第14卷 第5期 页码 880-888 doi: 10.1007/s11705-019-1864-6
关键词: hypoxia microtubule inhibitor drug delivery azo-combretastatin A4 photo-responsive
Xudong YU MM, Zengwu SHAO MD, Liming XIONG MD, Weiwei XU MM, Hezhong WANG MM, Huifa XU MM,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 415-420 doi: 10.1007/s11684-009-0072-z
关键词: tissue inhibitor of metalloproteinase-3 intervertebral disc rabbit gene therapy
Fe–Cr–Ni based alloys exposed to molten MgCl2–KCl–NaCl salt with over-added Mg corrosion inhibitor
《化学科学与工程前沿(英文)》 2023年 第17卷 第10期 页码 1608-1619 doi: 10.1007/s11705-023-2349-1
关键词: concentrated solar power (CSP) Mg corrosion inhibitor Mg–Ni intermetallic salt purification thermal energy storage (TES)
The secondary laticifer differentiation in rubber tree is induced by trichostatin A, an inhibitor of
Shixin ZHANG,Shaohua WU,Weimin TIAN
《农业科学与工程前沿(英文)》 2016年 第3卷 第4期 页码 357-362 doi: 10.15302/J-FASE-2016125
关键词: Hevea brasiliensis histone acetylation laticifer differentiation trichostatin vascular cambia
null
《医学前沿(英文)》 2016年 第10卷 第4期 页码 437-443 doi: 10.1007/s11684-016-0472-9
A phase II study (A2202) was performed to evaluate the efficacy and safety of JAK inhibitor ruxolitinib in 63 Chinese MF patients. Ruxolitinib was given twice a day (bid) at a starting dose of 15 mg (n=25) or 20 mg (n=38) based on a baseline platelet count. About 94.7% of the patients achieved a reduction in spleen size, 27.0% of which exhibited significant reduction (≥35%) at week 24. Significant improvement in debilitating constitutional symptoms, as assessed by MFSAF v2.0, was observed in patients treated with ruxolitinib. Ruxolitinib treatment was generally well tolerated by Chinese patients. Although the treatment was associated with an increase in certain adverse events (AEs) that were established as identified risks (anemia and thrombocytopenia), these AEs were considered manageable in this clinical setting. Ruxolitinib provided substantial reductions in splenomegaly and improvements in symptoms, and was well-tolerated by Chinese patients with MF.
Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects
Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao
《医学前沿(英文)》 2019年 第13卷 第4期 页码 427-437 doi: 10.1007/s11684-018-0672-6
关键词: targeted therapy desmoid-type fibromatosis tyrosine kinase inhibitor γ-secretase inhibitor
Hong LI, Shaoqin CHEN, Yi SHU, Yongjun CHEN, Ying SU, Xin WANG, Shengquan ZOU
《医学前沿(英文)》 2009年 第3卷 第2期 页码 153-157 doi: 10.1007/s11684-009-0034-5
关键词: DNA methylation inhibitor histone deacetylase inhibitor bile duct carcinoma E-cadherin
标题 作者 时间 类型 操作
Renin--angiotensin system inhibitor is associated with the reduced risk of all-cause mortality in COVID
期刊论文
Comparison between inhibitor and uncoupler for minimizing excess sludge production of an activated sludge
CHEN Guowei, XI Pengge, XU Deqian, YU Hanqing
期刊论文
Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis
null
期刊论文
Estimating the effect of urease inhibitor on rice yield based on NDVI at key growth stages
Kailou LIU,Yazhen LI,Huiwen HU
期刊论文
A small-molecule pan-HER inhibitor alone or in combination with cisplatin exerts efficacy against nasopharyngeal
期刊论文
Genomic regions associated with the sex-linked inhibitor of dermal melanin in Silkie chicken
Ming TIAN,Rui HAO,Suyun FANG,Yanqiang WANG,Xiaorong GU,Chungang FENG,Xiaoxiang HU,Ning LI
期刊论文
Rapamycin enhances the anti-tumor activity of cabozantinib in cMet inhibitor-resistant hepatocellular
期刊论文
Medical oncology management of advanced hepatocellular carcinoma 2019: a reality check
Amy Lee, Fa-Chyi Lee
期刊论文
Hypoxia-induced activity loss of a photo-responsive microtubule inhibitor azobenzene combretastatin A4
Yang An, Chao Chen, Jundong Zhu, Pankaj Dwivedi, Yanjun Zhao, Zheng Wang
期刊论文
Adenovirus-mediated tissue inhibitor of metalloproteinase-3 gene transfection inhibits rabbit intervertebral
Xudong YU MM, Zengwu SHAO MD, Liming XIONG MD, Weiwei XU MM, Hezhong WANG MM, Huifa XU MM,
期刊论文
Fe–Cr–Ni based alloys exposed to molten MgCl2–KCl–NaCl salt with over-added Mg corrosion inhibitor
期刊论文
The secondary laticifer differentiation in rubber tree is induced by trichostatin A, an inhibitor of
Shixin ZHANG,Shaohua WU,Weimin TIAN
期刊论文
Efficacy and safety of JAK inhibitor INC424 in patients with primary and post-polycythemia vera or post-essential
null
期刊论文
Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects
Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao
期刊论文