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Using mRNA to investigate the effect of low-pressure ultraviolet disinfection on the viability of
Chao Yang, Wenjun Sun, Xiuwei Ao
《环境科学与工程前沿(英文)》 2019年 第13卷 第2期 doi: 10.1007/s11783-019-1111-x
UV can induce damages on mRNA consistently among different genes. SOS response was more active after UV treatment. Programmed cell death was not found to be more active after UV treatment.
关键词: UV disinfection Viability mRNA SOS response Programmed cell death
Jennifer Welsh
《工程(英文)》 2021年 第7卷 第6期 页码 712-714 doi: 10.1016/j.eng.2021.04.005
Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient
《医学前沿(英文)》 2022年 第16卷 第1期 页码 150-155 doi: 10.1007/s11684-021-0846-5
Tim-3 mRNA expression in peripheral blood lymphocytes from asthmatic patients
Xiaoxia LU, Weikun HU, Shengdao XIONG, Guopeng XU, Fen LAN
《医学前沿(英文)》 2009年 第3卷 第2期 页码 187-190 doi: 10.1007/s11684-009-0033-6
关键词: asthma airway inflammation peripheral blood lymphocyte Tim-3
李爱花,杨雪梅,孙轶楠,苑亚坤,杨俊涛
《中国工程科学》 2021年 第23卷 第4期 页码 153-161 doi: 10.15302/J-SSCAE-2021.04.018
应对新型冠状病毒肺炎(COVID-19)疫情防控的迫切需求,核酸疫苗以其快速高效的优点得到了疫苗研发领域的高度重视,特别是信使核糖核酸(mRNA本文从核酸疫苗及相关技术概念、研发轨迹与发展趋势等方面总结梳理核酸疫苗的研发态势,辨识核酸疫苗特征,分析 COVID-19 疫情对 mRNA疫苗研究的促进作用,梳理核酸疫苗拓展应用的主要领域,针对可能存在的技术性研究建议,从改良目的基因表达、完善递送系统、提高免疫应答、增强 mRNA 稳定性及易存性等方面着手,着力开展核酸疫苗的关键技术开发;严格监管核酸疫苗的安全性和有效性;引导利益相关方对具有安全性风险、可能对肿瘤与传染病防控带来颠覆性影响的mRNA 疫苗技术开展改进研究,注重技术研发的前瞻布局并促进应用转化。
关键词: 核酸疫苗 脱氧核糖核酸(DNA)疫苗 核糖核酸(RNA)疫苗 信使核糖核酸(mRNA)疫苗 新型冠状病毒肺 炎 肿瘤
Effects of hypoxia on mRNA expression of housekeeping genes in rat brain tissue and primary cultured
YANG Yingzhong, MA Lan, GE Rili, FAN Wenhong, ZHU Lingling, ZHAO Tong, WU Yan, FAN Ming
《医学前沿(英文)》 2008年 第2卷 第3期 页码 239-243 doi: 10.1007/s11684-008-0045-7
关键词: Glyceraldehyde-3-phosphate dehydrogenase comparative constant unfavorable independent
Changes in lncRNAs and related genes in β-thalassemia minor and β-thalassemia major
null
《医学前沿(英文)》 2017年 第11卷 第1期 页码 74-86 doi: 10.1007/s11684-017-0503-1
β-thalassemia is caused by β-globin gene mutations. However, heterogeneous phenotypes were found in individuals with same genotype, and still undescribed mechanism underlies such variation. We collected blood samples from 30 β-thalassemia major, 30 β-thalassemia minor patients, and 30 matched normal controls. Human lncRNA Array v2.0 (8 × 60 K, Arraystar) was used to detect changes in long non-coding RNAs (lncRNAs) and mRNAs in three samples each from β-thalassemia major, β-thalassemia minor, and control groups. Compared with normal controls, 1424 and 2045 lncRNAs were up- and downregulated, respectively, in β-thalassemia major patients, whereas 623 and 349 lncRNAs were up- and downregulated, respectively, in β-thalassemia minor patients. Compared with β-thalassemia minor group, 1367 and 2356 lncRNAs were up- and downregulated, respectively, in β-thalassemia major group. We selected five lncRNAs that displayed altered expressions (DQ583499, X-inactive specific transcript (Xist), lincRNA-TPM1, MRFS16P, and lincRNA-RUNX2-2) and confirmed their expression levels in all samples using real-time polymerase chain reaction. Based on coding-non-coding gene co-expression network and gene ontology biological process analyses, several signaling pathways were associated with three common organ systems exhibiting β-thalassemia phenotypes: hematologic, skeletal, and hepatic systems. This study implicates that abnormal expression levels of lncRNAs and mRNA in β-thalassemia cases may be correlated with its various clinical phenotypes.
关键词: β-thalassemia long non-coding RNA mRNA phenotypic heterogeneity pathway
Expression pattern and regulation of head-to-head genes
Xinxing CUI,Chunhong YANG,Li KANG,Guiyu ZHU,Qingqing WEI,Yunliang JIANG
《农业科学与工程前沿(英文)》 2014年 第1卷 第2期 页码 130-136 doi: 10.15302/J-FASE-2014013
标题 作者 时间 类型 操作
Using mRNA to investigate the effect of low-pressure ultraviolet disinfection on the viability of
Chao Yang, Wenjun Sun, Xiuwei Ao
期刊论文
Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient
期刊论文
Tim-3 mRNA expression in peripheral blood lymphocytes from asthmatic patients
Xiaoxia LU, Weikun HU, Shengdao XIONG, Guopeng XU, Fen LAN
期刊论文
Effects of hypoxia on mRNA expression of housekeeping genes in rat brain tissue and primary cultured
YANG Yingzhong, MA Lan, GE Rili, FAN Wenhong, ZHU Lingling, ZHAO Tong, WU Yan, FAN Ming
期刊论文