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《医学前沿(英文)》 2014年 第8卷 第1期 页码 106-112 doi: 10.1007/s11684-014-0307-5
Cervical carcinoma is associated with high propensity for local invasion and lymph node metastasis. However, the molecular alterations that drive progression and metastasis of cervical cancer remain unclear. Cellular senescence has been proposed as the mechanism that protects an organism against cancer progression and metastasis. In addition, Twist, a basic helix-loop-helix transcription factor, has been suggested as an oncogene because it is overexpressed in many types of human cancer. This gene also exhibits a positive function in regulating invasion and metastasis. In this study, Twist was strongly and positively expressed in normal tissue, squamous cell carcinoma (SCC) IA--IIA, and SCC IIB--IIIB (4.3%, 44%, and 88.9%, respectively). The strong positive expressions of the senescence marker CBX3 were 39.1%, 32%, and 15.6%, respectively. The strong positive expressions of Twist in the SCC groups with or without lymph node metastasis were 80.8% and 50%. For CBX3, such expressions were 7.7% and 29.5%, respectively. Results also showed that the expression of Twist was inversely correlated with that of CBX3. Moreover, the knockdown of Twist with target siRNA in SiHa triggered the induction of the chromatin marker of the cellular senescence CBX3 and senescence-associated β-galactosidase activity. Our results suggested that the expression of Twist increased during the progression and metastasis of cervical cancer. Furthermore, Twist-induced senescence bypass is important in this process.
关键词: cervical cancer senescence Twist CBX3 lymph node metastasis
基于刚性与非刚性Square-Twist胞元混合排布的折纸超材料设计与性能编程研究 Article
马家耀, 臧世玺, 陈焱, 由衷
《工程(英文)》 2022年 第17卷 第10期 页码 82-92 doi: 10.1016/j.eng.2022.02.015
关键词: 折纸超材料 超材料 square-twist折纸 非周期性排布 可编程性
Wei HAN MM, Ming-Xing XIE MD, Qing LV MD, Xin-Fang WANG MD, Li ZHANG MM,
《医学前沿(英文)》 2010年 第4卷 第1期 页码 71-76 doi: 10.1007/s11684-010-0006-9
关键词: echocardiography twist two-dimensional strain imaging coronary artery disease
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《医学前沿(英文)》 2012年 第6卷 第3期 页码 329-331 doi: 10.1007/s11684-012-0211-9
Ischemic postconditioning was defined as rapid intermittent interruptions of blood ?ow in the early phase of reperfusion, which has been found to be protective against renal ischemia-reperfusion injury (IRI) in animal models but not in clinical trials. We describe a case that the allograft renal vein was twisted because of the surgeon’s mistake, which caused the warm ischemia of allograft after reperfusion. The allograft restored blood flow without second reperfusion and cold preservation after 9 min of warm ischemia. The patient was followed up for 3 months and the allograft worked well without complications.
关键词: renal transplantation vein twist ischemia-reperfusion injury
标题 作者 时间 类型 操作
Correlation of Twist upregulation and senescence bypass during the progression and metastasis of cervical
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期刊论文
Assessment of global and regional left ventricular twist and displacement in anterior myocardial infarction
Wei HAN MM, Ming-Xing XIE MD, Qing LV MD, Xin-Fang WANG MD, Li ZHANG MM,
期刊论文