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2008 2

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Vein of Galen malformations - report of 2 cases and literature review

CAI Chunquan, ZHANG Qingjiang, SHEN Changhong

《医学前沿（英文）》 2008年第2卷第3期页码 317-322 doi: 10.1007/s11684-008-0061-7

摘要： Vein of Galen malformations (VGMs) are rare, consisting approximately 1% of intracranial vascular malformations, but nearly one third of pediatric vascular malformations, which can cause severe morbidity and mortality in infants and older children, but more particularly in neonates. We presented 2 patients with VGMs which were confirmed by characteristic clinical symptoms and neuroradiological findings (including CT, MRI and/or angiography). One patient underwent embolization followed by CT, MRI and conventional angiography. The patient’s neurological and cognitive status was normal at present. The other neonate died of congestive heart failure 36 h after birth.

关键词： underwent embolization angiography pediatric vascular cognitive characteristic

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Effects of Decoction on plasma proteome in cirrhosis: preliminary experimental study with rats

LIU Jie, WANG Jiyao, WEI Liming, LU Ye, Jin Hong

《医学前沿（英文）》 2008年第2卷第1期页码 39-44 doi: 10.1007/s11684-008-0008-z

摘要： The aim of this paper is to study the effects of Decoction on the plasma proteome in cirrhotic rats. Twenty-six male Sprague-Dawley (SD) rats were randomly divided into three groups: cirrhotic model group ( = 10), treated with CCl (CCl/olive oil: v/v = 1:1); Decoction intervention group ( = 10), treated with CCl+ Decoction; and normal control group ( = 6), treated with olive oil only. After 8 weeks, blood samples were collected from the inferior vena cava to undergo bi-dimensional electrophoresis (2DE) and analysis by PDQuest 7.3 software. Differential protein spots were cut, enzyme hydrolysis was conducted, and peptide fragments extracted from the mixture underwent mass spectrometry (MS) with MALDI-TOF-TOF-MS. The liver fibrogenesis was assessed using a digital image analysis instrument of Masson’s trichrome stained sections. The fibrosis area of the Decoction was (8.9 ± 3.7)%, significantly smaller than that of the cirrhotic model group [(12.4 ± 4.7)%, < 0.05]. Ten markedly changed protein spots were identified by MALDI-TOF-TOF-MS. Eight of the 10 proteins, including plasma glutathione peroxidase, plasma glutathione peroxidase precursor, prealbumin, haptoglobin, apolipoprotein A-IV precursor, complement C4, inter-alpha-inhibitor H4 heavy chain, and serine/threonine-protein kinase microtubule-affinity regulating kinase 1 (MARK1) were expressed very lowly in the cirrhotic model group while they were expressed highly in the Decoction group. The expression of liver regeneration-related protein LRRG03 and vimentin increased in the cirrhotic model group, and reduced in the Decoction group. Some proteins related to oxidative stress, cell proliferation and transformation have changed in the plasma of cirrhosis induced by CCl. Decoction promotes protein synthesis and plays an anti-fibrotic role by anti-oxidation and accommodation of cell proliferation and transformation.

关键词： Decoction intervention serine/threonine-protein underwent Decoction glutathione peroxidase