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《医学前沿(英文)》 2015年 第9卷 第3期 页码 288-303 doi: 10.1007/s11684-015-0412-0
Toll-like receptors (TLRs), which are found in innate immune cells, are essential mediators of rapid inflammatory responses and appropriate T-cell activation in response to infection and tissue damage. Accumulating evidence suggests that TLR signaling is involved in normal hematopoiesis and specific hematologic pathologies. Particular TLRs and their downstream signaling mediators are expressed not only in terminally differentiated innate immune cells but also in early hematopoietic progenitors. Sterile activation of TLR signaling is required to generate early embryonic hematopoietic progenitor cells. In adult animals, TLR signaling directly or indirectly promotes differentiation of myeloid cells at the expense of that of lymphoid cells and the self-renewal of hematopoietic stem cells during infection and tissue damage. Activating mutations of the MyD88 gene, which codes for a key adaptor involved in TLR signaling, are commonly detected in B-cell lymphomas and other B-cell hematopathologies. Dysregulated TLR signaling contributes to the pathogenesis of many hematopoietic disorders, including bone marrow failure, myelodysplastic syndrome, and acute myeloid leukemia. Complete elucidation of the molecular mechanisms by which TLR signaling mediates the regulation of both normal and pathogenic hematopoiesis will prove valuable to the development of targeted therapies and strategies for improved treatment of hematopoietic disorders.
关键词: TLR MyD88 hematopoiesis bone marrow failure leukemia myelodysplastic syndrome
Human-cyber-physical systems: concepts, challenges, and research opportunities
Zhiming Liu, Ji Wang,zhimingliu88@swu.edu.cn,jiwang@ios.ac.cn
《信息与电子工程前沿(英文)》 2020年 第21卷 第11期 页码 1535-1670 doi: 10.1631/FITEE.2000537
Carbon nanotubes-incorporated MIL-88B-Fe as highly efficient Fenton-like catalyst for degradation of
Hang Zhang, Shuo Chen, Haiguang Zhang, Xinfei Fan, Cong Gao, Hongtao Yu, Xie Quan
《环境科学与工程前沿(英文)》 2019年 第13卷 第2期 doi: 10.1007/s11783-019-1101-z
CNTs were incorporated into MIL-88B-Fe to get a new Fenton-like catalyst (C@M). Fe(II) was introduced in C@M to get a fast initiation of Fenton-like reaction. Fe(II) content in C@M was related with oxygen-containing functional groups on CNTs. C@M shows efficient catalytic degradation of pollutants over a wide pH range.
关键词: Heterogeneous Fenton-like catalysts MIL-88B-Fe CNTs Organic pollutants Mechanism
Ehsan Rahmani, Mohammad Rahmani
《化学科学与工程前沿(英文)》 2020年 第14卷 第6期 页码 1100-1111 doi: 10.1007/s11705-019-1891-3
关键词: MOFs alkylation ethylbenzene catalysts pellet model kinetic model sensitivity analysis
标题 作者 时间 类型 操作
Toll-like receptor signaling in hematopoietic homeostasis and the pathogenesis of hematologic diseases
null
期刊论文
Human-cyber-physical systems: concepts, challenges, and research opportunities
Zhiming Liu, Ji Wang,zhimingliu88@swu.edu.cn,jiwang@ios.ac.cn
期刊论文
Carbon nanotubes-incorporated MIL-88B-Fe as highly efficient Fenton-like catalyst for degradation of
Hang Zhang, Shuo Chen, Haiguang Zhang, Xinfei Fan, Cong Gao, Hongtao Yu, Xie Quan
期刊论文