Broadly neutralizing antibodies and vaccine design against HIV-1 infection

2020, Volume 14, Issue 1

Abstract

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Frontiers of Medicine >> 2020, Volume 14, Issue 1 doi: 10.1007/s11684-019-0721-9

Broadly neutralizing antibodies and vaccine design against HIV-1 infection

Comprehensive AIDS Research Center, Beijing Advanced Innovation Center for Structural Biology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China

Accepted: 2019-12-19 Available online: 2019-12-19

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Abstract

Remarkable progress has been achieved for prophylactic and therapeutic interventions against human immunodeficiency virus type I (HIV-1) through antiretroviral therapy. However, vaccine development has remained challenging. Recent discoveries in broadly neutralizing monoclonal antibodies (bNAbs) has led to the development of multiple novel vaccine approaches for inducing bNAbs-like antibody response. Structural and dynamic studies revealed several vulnerable sites and states of the HIV-1 envelop glycoprotein (Env) during infection. Our review aims to highlight these discoveries and rejuvenate our endeavor in HIV-1 vaccine design and development.

Keywords

HIV-1 ; broadly neutralizing antibodies ; Env conformational states ; vaccine design ; SOSIP

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