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Broadly neutralizing antibodies and vaccine design against HIV-1 infection

Qian Wang, Linqi Zhang

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 30-42 doi: 10.1007/s11684-019-0721-9

Abstract: achieved for prophylactic and therapeutic interventions against human immunodeficiency virus type I (HIV-1-1) through antiretroviral therapy.Structural and dynamic studies revealed several vulnerable sites and states of the HIV-1 envelop glycoproteinOur review aims to highlight these discoveries and rejuvenate our endeavor in HIV-1 vaccine design and

Keywords: HIV-1     broadly neutralizing antibodies     Env conformational states     vaccine design     SOSIP    

Irreversible phenotypic perturbation and functional impairment of B cells during HIV-1 infection

Jingjing Yan, Shuye Zhang, Jun Sun, Jianqing Xu, Xiaoyan Zhang

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 409-409 doi: 10.1007/s11684-018-0618-z

Smartphone-Imaged HIV-1 Reverse-Transcription Loop-Mediated Isothermal Amplification (RT-LAMP) on a Chip Article

Gregory L. Damhorst,Carlos Duarte-Guevara,Weili Chen,Tanmay Ghonge,Brian T. Cunningham,Rashid Bashir

Engineering 2015, Volume 1, Issue 3,   Pages 324-335 doi: 10.15302/J-ENG-2015072

Abstract: measurements are an essential tool for the long-term clinical care of human immunodeficiency virus (HIVpoor healthcare infrastructure, including parts of the world that are disproportionately affected by HIVperform reverse-transcription loop-mediated isothermal amplification (RT-LAMP) on minimally processed HIV-spikedscaled up for the determination of viral load from a finger prick of blood in the clinical care of HIV-positive

Keywords: human immunodeficiency virus (HIV)     viral load     loop-mediated isothermal amplification     smartphone     point-of-care    

Pregnancy outcome analysis of HIV infected women in Xinjiang, 2010—2013

Shawuli∙Ailika,Aibibai∙Maimaitiming,Wang Xiaojun

Strategic Study of CAE 2015, Volume 17, Issue 6,   Pages 50-52

Abstract:

To understand pregnancy outcomes of HIV infected women in Xinjiang.We collected and analyzed 2256 HIV infected women reported by PMTCT management information reportingunemployed), first marriage( 56.12 %), remarried ( 37.19%). 2 times or more pregnancies ( 69.68%), 316 HIVinfected women didn’t stop pregnancy after knowing their HIV infected status, accounts for 14.01%The research suggest that we should strengthen counseling and services and contraception for HIV-infected

Keywords: HIV infected pregnant women     unwilling pregnancy     reproductive health    

Molecular network-based intervention brings us closer to ending the HIV pandemic

Xiaoxu Han, Bin Zhao, Minghui An, Ping Zhong, Hong Shang

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 136-148 doi: 10.1007/s11684-020-0756-y

Abstract: Precise identification of HIV transmission among populations is a key step in public health responsesHowever, the HIV transmission network is usually difficult to determine.HIV molecular networks can be determined by phylogenetic approach, genetic distance-based approach, andare increasingly used to identify transmission networks among populations, reconstruct the history of HIVspread, monitor the dynamics of HIV transmission, guide targeted intervention on key subpopulations,

Keywords: human immunodeficiency virus type 1     molecular cluster     transmission cluster     risk network     targeted intervention    

Practices, challenges, and opportunities: HIV/AIDS treatment with traditional Chinese medicine in China

Jian Wang, Wen Zou

Frontiers of Medicine 2011, Volume 5, Issue 2,   Pages 123-126 doi: 10.1007/s11684-011-0124-z

Abstract: In this article, we summarize the recent major developments in human immunodeficiency virus/AIDS (HIVThe use of TCM is associated with preventing or alleviating HIV-related symptoms, reducing treatment

Keywords: HIV/AIDS     traditional Chinese medicine    

Marriage analysis of HIV infected pregnant women

Shawuli·Ailika,Wang Xiaojun and Aibibai·Maimaitiming

Strategic Study of CAE 2014, Volume 16, Issue 5,   Pages 60-62

Abstract:

This paper aims at understanding the marriage situation of HIV infectedof HIV maternal-neonatal transmission during 2010 to 2012,so as to provide reproductive health educationfor HIV infected women.The result shows that:The average age of 1 692 HIV infected women is 29.03,of which 53.31 % is 20~29,so it is very important to develop reproductive health education for HIV infected women.

Keywords: HIV infected pregnant women     infected women     marriage transmission     reproductive health    

Design, synthesis and HIV-RT inhibitory activity of novel thiazolidin-4-one derivatives

Hua CHEN, Zaihong GUO, Qingmei YIN, Xiaoxu DUAN, Yunjing GU, Xiaoliu LI

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 2,   Pages 231-237 doi: 10.1007/s11705-010-1022-7

Abstract: methyl ( and ) at C-5 on thiazolidin-4-one ring were designed, synthesized and evaluated for their HIV-RTPreliminary anti-HIV-RT test of these derivatives indicated that compounds – , (propionyloxy groupat C-5) showed moderate HIV-RT inhibitory activity and compounds and with methyl at C-5 showed aweak HIV-RT inhibitory activity.activity and that the steric effect might play a critical role in the anti-HIV RT activity.

Keywords: 5-subsituted thiazolidin-4-ones     Pummerer reaction     anti-HIV-RT activity     SARs    

An 84-month observational study of the changes in CD4 T-lymphocyte cell count of 110 HIV/AIDS patients

Jian Wang,Biyan Liang,Xiaoping Zhang,Liran Xu,Xin Deng,Xiuhui Li,Lu Fang,Xinghua Tan,Yuxiang Mao,Guoliang Zhang,Yuguang Wang

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 362-367 doi: 10.1007/s11684-014-0363-x

Abstract: observing the changes in CD4 T-lymphocyte cell count of 110 cases with human immunodeficiency virus (HIVInformation of 110 HIV/AIDS patients from 19 provinces and cities treated with TCM from 2004 to 2013Long-term use of TCM could maintain or slow the pace of declining CD4 counts in patients with HIV/AIDS

Keywords: AIDS     HIV     CD4     traditional Chinese medicine     linear models    

Natural history of HIV infection in former plasma donors in rural China

Min ZHANG, Hong SHANG, Zhe WANG, Wei-Guo CUI, Qing-Hai HU

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 346-350 doi: 10.1007/s11684-010-0102-x

Abstract: FPDs all have an approximate time of human immunodeficiency virus (HIV) infection during the mid-1990sFew studies about the natural history of HIV infection in these patients were performed.A retrospective cohort study was conducted based on data collected from 5484 HIV-1 infected FPDs in ShangcaiThis is the first large-scale retrospective study on the natural history of HIV infection in FPDs in

Keywords: human immunodeficiency virus (HIV)     former plasma donor     natural history     China    

Molecular epidemiology of Cryptococcus neoformans species complex isolates from HIV-positive and HIV-negative

Min CHEN MM, Wei-Hua PAN MD, Wan-Qing LIAO MM, Xiao-Ran LI BS, Bi-Wei FENG BS, Zhe-Xue QUAN PhD, Shao-Xi WU MD, Xiao-Ping TANG MD, Zhi-Rong YAO MD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 117-126 doi: 10.1007/s11684-010-0011-z

Abstract: )-positive and HIV-negative patients in southeast China in the past 15 years.(72%, 64/89), VNII (13%, 12/89), VGI (12%, 11/89), VNIII (1%, 1/89), and VGII (1%, 1/89).(1/109) were of theα/.These results suggest that both HIV-positive and HIV-negative cryptococcal patients in the southeastNo strains were found in HIV-positive patients.

Keywords: Cryptococcus neoformans     Cryptococcus gattii     cryptococcosis     molecular epidemiology     molecular type     mating type    

TCM Views and Treatment on AIDS

Wang Wenkui

Strategic Study of CAE 2004, Volume 6, Issue 1,   Pages 44-47

Abstract:

Serious dysfunction of cell-mediated immune is the internal cause of AIDS infection, and the virus is the external cause. The external cause will work only by means of the dysfunction of cell-mediated immune. As all the conditions on which normal cell depends are created by the viscera (zang and fu) function, proper measures can be adopted to adjust the viscera function comprehensively, so the physical materials can be produced, then the essence and sprit emerged. Only with supporting from physical materials, essence and sprit, can the cell-mediated immune function be kept well to conquer and destroy the different kinds of virus, hence keeping physical and psychological well-being, strengthening the human immunity. So that the normal physiological activity can be maintained.

Keywords: TCM views and theatment     HIV/AIDS     immunity     viscera function    

NRTIs’ effect on the sequence of mitochondrial DNA HV 2 in HIV infected patients

Ya-Song WU MD, PhD, Xin-Yue CHEN MD, Ying SHI PhD, Hao WU MD, De-Xi CHEN MD, PhD, Yu SUN MD, Fu-Jie ZHANG MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 177-184 doi: 10.1007/s11684-010-0038-1

Abstract: has significantly improved the life expectancy of people living with human immunodeficiency virus (HIVNRTIs could induce the hypervariable region (HV) mutations of the D loop of mitochondria in Chinese HIV

Keywords: nucleoside reverse transcriptase inhibitors     human immunodeficiency virus     mitochondrial DNA     D loop     mutation    

Study on factors affecting TB/HIV co-infection in four counties of China

Shi-Ming CHENG MD, Yu-Ji LAI MS, Er-Yong LIU MS, Lin ZHOU MD, Xue-Jing WANG MS, Qiu-Lan CHEN MS, Dong-Ming LI MS, Ning WANG MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 185-191 doi: 10.1007/s11684-010-0040-7

Abstract: and HIV institutions were selected.HIV test among TB patients and TB examination among people living with HIV/acquired immunodeficiencyPatients also completed questionnaires on potential factors affecting TB/HIV co-infection.who received HIV testing.TB checks should be conducted for HIV/AIDS patients.

Keywords: tuberculosis/acquired immunodeficiency syndrome     dual infection     prevention and control     case detection     impact factors    

Co-infection of HIV and parasites in China: Results from an epidemiological survey in rural areas of

Li-Guang TIAN MPH, Jia-Xu CHEN PhD, Yu-Chun CAI BM, Jian GUO MPH, Xiao-Mei TONG, Qin LIU DVM, Xiao-Nong ZHOU PhD, Tian-Ping WANG PhD, Xiao-Mei YIN, Wei-Duo WU, Li ZHOU, Feng-Feng WANG, Zhen-Li WANG MSc, Guo-Jin CHENG, Peter STEINMANN PhD, Lan-Hua LI MSc,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 192-198 doi: 10.1007/s11684-010-0039-0

Abstract: parasites in a HIV/AIDS highly endemic area in China.1%.Blood examination was performed for the HIV infection detection and anemia test.the co-infection rates of HIV and , and HIV and spp. were 19.57% and 13.04%, respectively.A significant difference of spp. infection rate was found between HIV-positive group (13.04%) and HIV-negative

Keywords: human immunodeficiency virus (HIV)     acquired immunodeficiency syndrome (AIDS)     co-infection     intestinal    

Title Author Date Type Operation

Broadly neutralizing antibodies and vaccine design against HIV-1 infection

Qian Wang, Linqi Zhang

Journal Article

Irreversible phenotypic perturbation and functional impairment of B cells during HIV-1 infection

Jingjing Yan, Shuye Zhang, Jun Sun, Jianqing Xu, Xiaoyan Zhang

Journal Article

Smartphone-Imaged HIV-1 Reverse-Transcription Loop-Mediated Isothermal Amplification (RT-LAMP) on a Chip

Gregory L. Damhorst,Carlos Duarte-Guevara,Weili Chen,Tanmay Ghonge,Brian T. Cunningham,Rashid Bashir

Journal Article

Pregnancy outcome analysis of HIV infected women in Xinjiang, 2010—2013

Shawuli∙Ailika,Aibibai∙Maimaitiming,Wang Xiaojun

Journal Article

Molecular network-based intervention brings us closer to ending the HIV pandemic

Xiaoxu Han, Bin Zhao, Minghui An, Ping Zhong, Hong Shang

Journal Article

Practices, challenges, and opportunities: HIV/AIDS treatment with traditional Chinese medicine in China

Jian Wang, Wen Zou

Journal Article

Marriage analysis of HIV infected pregnant women

Shawuli·Ailika,Wang Xiaojun and Aibibai·Maimaitiming

Journal Article

Design, synthesis and HIV-RT inhibitory activity of novel thiazolidin-4-one derivatives

Hua CHEN, Zaihong GUO, Qingmei YIN, Xiaoxu DUAN, Yunjing GU, Xiaoliu LI

Journal Article

An 84-month observational study of the changes in CD4 T-lymphocyte cell count of 110 HIV/AIDS patients

Jian Wang,Biyan Liang,Xiaoping Zhang,Liran Xu,Xin Deng,Xiuhui Li,Lu Fang,Xinghua Tan,Yuxiang Mao,Guoliang Zhang,Yuguang Wang

Journal Article

Natural history of HIV infection in former plasma donors in rural China

Min ZHANG, Hong SHANG, Zhe WANG, Wei-Guo CUI, Qing-Hai HU

Journal Article

Molecular epidemiology of Cryptococcus neoformans species complex isolates from HIV-positive and HIV-negative

Min CHEN MM, Wei-Hua PAN MD, Wan-Qing LIAO MM, Xiao-Ran LI BS, Bi-Wei FENG BS, Zhe-Xue QUAN PhD, Shao-Xi WU MD, Xiao-Ping TANG MD, Zhi-Rong YAO MD,

Journal Article

TCM Views and Treatment on AIDS

Wang Wenkui

Journal Article

NRTIs’ effect on the sequence of mitochondrial DNA HV 2 in HIV infected patients

Ya-Song WU MD, PhD, Xin-Yue CHEN MD, Ying SHI PhD, Hao WU MD, De-Xi CHEN MD, PhD, Yu SUN MD, Fu-Jie ZHANG MD,

Journal Article

Study on factors affecting TB/HIV co-infection in four counties of China

Shi-Ming CHENG MD, Yu-Ji LAI MS, Er-Yong LIU MS, Lin ZHOU MD, Xue-Jing WANG MS, Qiu-Lan CHEN MS, Dong-Ming LI MS, Ning WANG MD,

Journal Article

Co-infection of HIV and parasites in China: Results from an epidemiological survey in rural areas of

Li-Guang TIAN MPH, Jia-Xu CHEN PhD, Yu-Chun CAI BM, Jian GUO MPH, Xiao-Mei TONG, Qin LIU DVM, Xiao-Nong ZHOU PhD, Tian-Ping WANG PhD, Xiao-Mei YIN, Wei-Duo WU, Li ZHOU, Feng-Feng WANG, Zhen-Li WANG MSc, Guo-Jin CHENG, Peter STEINMANN PhD, Lan-Hua LI MSc,

Journal Article